Gene description for PTPMT1
Gene name protein tyrosine phosphatase, mitochondrial 1
Gene symbol PTPMT1
Other names/aliases DUSP23
MOSP
PLIP
PNAS-129
Species Homo sapiens
 Database cross references - PTPMT1
ExoCarta ExoCarta_114971
Vesiclepedia VP_114971
Entrez Gene 114971
HGNC 26965
MIM 609538
UniProt Q8WUK0  
 PTPMT1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTPMT1
Molecular Function
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    phosphatidylglycerophosphatase activity GO:0008962 IBA
    phosphatidylglycerophosphatase activity GO:0008962 ISS
    myosin phosphatase activity GO:0017018 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    cardiolipin biosynthetic process GO:0032049 ISS
    cardiolipin biosynthetic process GO:0032049 TAS
    regulation of intrinsic apoptotic signaling pathway GO:2001242 IGI
Subcellular Localization
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IEA
 Experiment description of studies that identified PTPMT1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTPMT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
2 COX5A 9377
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 AFG3L2 10939
Affinity Capture-MS Homo sapiens
5 TMEM14B  
Two-hybrid Homo sapiens
6 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 OXCT1 5019
Affinity Capture-MS Homo sapiens
8 JMJD4  
Affinity Capture-MS Homo sapiens
9 LCE2C  
Two-hybrid Homo sapiens
10 OXA1L  
Affinity Capture-MS Homo sapiens
11 CISD1 55847
Affinity Capture-MS Homo sapiens
12 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 TAB1 10454
Two-hybrid Homo sapiens
14 SLC25A1 6576
Affinity Capture-MS Homo sapiens
15 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 KRTAP5-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 CD79A  
Affinity Capture-MS Homo sapiens
18 DNAJC15  
Proximity Label-MS Homo sapiens
19 CCDC90B  
Proximity Label-MS Homo sapiens
20 KRTAP12-3  
Two-hybrid Homo sapiens
21 KIAA1429 25962
Affinity Capture-MS Homo sapiens
22 SLC18A2  
Affinity Capture-MS Homo sapiens
23 KRTAP4-12  
Two-hybrid Homo sapiens
24 MCU 90550
Proximity Label-MS Homo sapiens
25 SSC4D  
Two-hybrid Homo sapiens
26 COQ9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PTPMT1 114971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CHCHD2  
Affinity Capture-MS Homo sapiens
29 KRTAP2-4  
Two-hybrid Homo sapiens
30 FBXW7  
Affinity Capture-MS Homo sapiens
31 KRT40  
Two-hybrid Homo sapiens
32 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ATP2A2 488
Affinity Capture-MS Homo sapiens
34 MTUS2 23281
Two-hybrid Homo sapiens
35 KRTAP1-3  
Two-hybrid Homo sapiens
36 SURF1  
Proximity Label-MS Homo sapiens
37 ATP5O 539
Affinity Capture-MS Homo sapiens
38 RGS20 8601
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 KRTAP10-3  
Two-hybrid Homo sapiens
40 HINT3 135114
Affinity Capture-MS Homo sapiens
41 HYPM  
Affinity Capture-MS Homo sapiens
42 ATP5H 10476
Affinity Capture-MS Homo sapiens
43 TIMM50 92609
Affinity Capture-MS Homo sapiens
44 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SLC25A3 5250
Affinity Capture-MS Homo sapiens
46 SFXN1 94081
Affinity Capture-MS Homo sapiens
47 MDH2 4191
Proximity Label-MS Homo sapiens
48 PAM16  
Affinity Capture-MS Homo sapiens
49 STOML2 30968
Affinity Capture-MS Homo sapiens
50 ADAMTSL4  
Two-hybrid Homo sapiens
51 BSG 682
Affinity Capture-MS Homo sapiens
52 ATP5J 522
Affinity Capture-MS Homo sapiens
53 KRT34  
Two-hybrid Homo sapiens
54 MTCH2 23788
Affinity Capture-MS Homo sapiens
55 FOXA1  
Affinity Capture-MS Homo sapiens
56 COX15 1355
Proximity Label-MS Homo sapiens
57 KRT31 3881
Two-hybrid Homo sapiens
58 Ppp6c 67857
Affinity Capture-MS Mus musculus
59 NDUFA8 4702
Affinity Capture-MS Homo sapiens
60 KLK1 3816
Affinity Capture-MS Homo sapiens
61 RCCD1  
Affinity Capture-MS Homo sapiens
62 USMG5 84833
Affinity Capture-MS Homo sapiens
63 CYSRT1 375791
Two-hybrid Homo sapiens
64 COPS5 10987
Affinity Capture-MS Homo sapiens
65 CCDC109B 55013
Proximity Label-MS Homo sapiens
66 C20orf24  
Affinity Capture-MS Homo sapiens
67 POLDIP2 26073
Affinity Capture-MS Homo sapiens
68 PML 5371
Affinity Capture-MS Homo sapiens
69 PAK7  
Affinity Capture-MS Homo sapiens
70 ACSL4 2182
Affinity Capture-MS Homo sapiens
71 TMEM70  
Proximity Label-MS Homo sapiens
72 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
73 IPO9 55705
Affinity Capture-MS Homo sapiens
74 SNAP29 9342
Affinity Capture-MS Homo sapiens
75 KRTAP10-7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
76 CPT2 1376
Affinity Capture-MS Homo sapiens
77 KRTAP9-3  
Two-hybrid Homo sapiens
78 ANLN 54443
Affinity Capture-MS Homo sapiens
79 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 SLC16A1 6566
Affinity Capture-MS Homo sapiens
81 ECH1 1891
Affinity Capture-MS Homo sapiens
82 RAMP2  
Affinity Capture-MS Homo sapiens
83 FTL 2512
Affinity Capture-MS Homo sapiens
84 LETM1 3954
Affinity Capture-MS Homo sapiens
85 UQCRC2 7385
Affinity Capture-MS Homo sapiens
86 KRTAP10-8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
87 UQCRB 7381
Affinity Capture-MS Homo sapiens
88 ERGIC3 51614
Affinity Capture-MS Homo sapiens
89 ATP5F1 515
Affinity Capture-MS Homo sapiens
90 EGFR 1956
Negative Genetic Homo sapiens
91 FKBP8 23770
Affinity Capture-MS Homo sapiens
92 FBXO6 26270
Affinity Capture-MS Homo sapiens
93 AQP3  
Affinity Capture-MS Homo sapiens
94 BPNT1 10380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 DUSP6 1848
Affinity Capture-MS Homo sapiens
96 C17orf80 55028
Proximity Label-MS Homo sapiens
97 PMPCB 9512
Affinity Capture-MS Homo sapiens
98 MAPK6  
Two-hybrid Homo sapiens
99 ABTB2 25841
Affinity Capture-MS Homo sapiens
100 ATP2A1 487
Affinity Capture-MS Homo sapiens
101 TRIM27  
Two-hybrid Homo sapiens
102 ACAD9 28976
Proximity Label-MS Homo sapiens
103 KRTAP9-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 DDRGK1 65992
Affinity Capture-MS Homo sapiens
105 CLPB 81570
Affinity Capture-MS Homo sapiens
106 ATP5C1 509
Affinity Capture-MS Homo sapiens
107 SLC22A4 6583
Affinity Capture-MS Homo sapiens
108 CBWD1 55871
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 CYCS 54205
Affinity Capture-MS Homo sapiens
110 MCUR1 63933
Proximity Label-MS Homo sapiens
111 IMMT 10989
Affinity Capture-MS Homo sapiens
112 SLC2A12 154091
Affinity Capture-MS Homo sapiens
113 CLPP 8192
Proximity Label-MS Homo sapiens
114 DNAJC28  
Proximity Label-MS Homo sapiens
115 KRTAP3-1  
Two-hybrid Homo sapiens
116 GLS 2744
Affinity Capture-MS Homo sapiens
117 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
118 Tubg1 103733
Affinity Capture-MS Mus musculus
119 CLPX 10845
Affinity Capture-MS Homo sapiens
120 SLC18A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 NUP133 55746
Affinity Capture-MS Homo sapiens
122 DNAJC19 131118
Proximity Label-MS Homo sapiens
123 FBXL6  
Affinity Capture-MS Homo sapiens
124 NDUFAF2  
Affinity Capture-MS Homo sapiens
125 COQ5  
Affinity Capture-MS Homo sapiens
126 MFSD4  
Affinity Capture-MS Homo sapiens
127 NBPF19  
Two-hybrid Homo sapiens
128 PDHA1 5160
Proximity Label-MS Homo sapiens
129 DNAJA3 9093
Proximity Label-MS Homo sapiens
130 COQ7  
Affinity Capture-MS Homo sapiens
131 CDH23 64072
Affinity Capture-MS Homo sapiens
132 COX8A  
Proximity Label-MS Homo sapiens
133 C21orf33  
Proximity Label-MS Homo sapiens
134 MKI67  
Affinity Capture-MS Homo sapiens
135 KRTAP5-7  
Two-hybrid Homo sapiens
136 XPO4 64328
Affinity Capture-MS Homo sapiens
137 ATAD3A 55210
Affinity Capture-MS Homo sapiens
138 AARS2  
Proximity Label-MS Homo sapiens
139 SLC25A51  
Proximity Label-MS Homo sapiens
140 COX7A2 1347
Affinity Capture-MS Homo sapiens
141 NDUFS3 4722
Affinity Capture-MS Homo sapiens
142 C1QBP 708
Affinity Capture-MS Homo sapiens
143 KRAS 3845
Negative Genetic Homo sapiens
144 C9orf72  
Affinity Capture-MS Homo sapiens
145 SLC1A1 6505
Affinity Capture-MS Homo sapiens
146 TIMM44 10469
Affinity Capture-MS Homo sapiens
147 KRTAP10-9  
Two-hybrid Homo sapiens
148 ATP5E 514
Affinity Capture-MS Homo sapiens
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