Gene description for SLC2A12
Gene name solute carrier family 2 (facilitated glucose transporter), member 12
Gene symbol SLC2A12
Other names/aliases GLUT12
GLUT8
Species Homo sapiens
 Database cross references - SLC2A12
ExoCarta ExoCarta_154091
Vesiclepedia VP_154091
Entrez Gene 154091
HGNC 18067
MIM 610372
UniProt Q8TD20  
 SLC2A12 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC2A12
Molecular Function
    D-glucose transmembrane transporter activity GO:0055056 IBA
    D-glucose transmembrane transporter activity GO:0055056 TAS
Biological Process
    hexose transmembrane transport GO:0008645 TAS
    circulatory system development GO:0072359 IBA
    D-glucose transmembrane transport GO:1904659 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    endomembrane system GO:0012505 IEA
    membrane GO:0016020 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified SLC2A12 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC2A12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TARBP1 6894
Affinity Capture-MS Homo sapiens
2 SLC25A23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FITM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SPPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GHITM 27069
Affinity Capture-MS Homo sapiens
6 BIRC2  
Affinity Capture-MS Homo sapiens
7 SLC19A2 10560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PIGW  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PEX16 9409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 KIF14 9928
Affinity Capture-MS Homo sapiens
11 SPG7  
Affinity Capture-MS Homo sapiens
12 ABCB8 11194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DNAJC19 131118
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SELT 51714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TP53 7157
Affinity Capture-MS Homo sapiens
16 FASTKD1  
Affinity Capture-MS Homo sapiens
17 RER1 11079
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 DNM3 26052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ECT2 1894
Affinity Capture-MS Homo sapiens
20 MTX1 4580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 HOXD13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 EFR3A 23167
Affinity Capture-MS Homo sapiens
23 ATL2 64225
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SLC25A28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 GPR12  
Affinity Capture-MS Homo sapiens
26 KIF20A 10112
Affinity Capture-MS Homo sapiens
27 ABHD3  
Affinity Capture-MS Homo sapiens
28 ASMTL 8623
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TTK 7272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TMEM11 8834
Affinity Capture-MS Homo sapiens
31 ORMDL3 94103
Affinity Capture-MS Homo sapiens
32 GNL1 2794
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 MTFR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TMEM242  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SERINC1 57515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SLC25A24 29957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 WDFY3 23001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HACD2 201562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TSPO 706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 KIRREL 55243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ABCF2 10061
Affinity Capture-MS Homo sapiens
43 TM2D3  
Affinity Capture-MS Homo sapiens
44 ALG8  
Affinity Capture-MS Homo sapiens
45 C4orf29 80167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CHMP4B 128866
Affinity Capture-MS Homo sapiens
47 TAMM41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SFXN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CYBA 1535
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BCS1L 617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SLC25A51  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PTPMT1 114971
Affinity Capture-MS Homo sapiens
53 DOLK 22845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SMAP2 64744
Affinity Capture-MS Homo sapiens
55 EBP  
Affinity Capture-MS Homo sapiens
56 TMEM164  
Affinity Capture-MS Homo sapiens
57 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 PRC1 9055
Affinity Capture-MS Homo sapiens
59 CERS6  
Affinity Capture-MS Homo sapiens
60 ADCK4 79934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 TVP23C  
Affinity Capture-MS Homo sapiens
62 ATL3 25923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CHST11 50515
Affinity Capture-MS Homo sapiens
64 ABHD17B 51104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 APOL2 23780
Affinity Capture-MS Homo sapiens
66 NSUN3  
Affinity Capture-MS Homo sapiens
67 ACAD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 METTL15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 PARL  
Affinity Capture-MS Homo sapiens
70 PDXDC1 23042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ORMDL2 29095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC2A12 is involved
PathwayEvidenceSource
Cellular hexose transport TAS Reactome
SLC-mediated transmembrane transport TAS Reactome
Transport of small molecules TAS Reactome





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