Gene description for SLC2A12
Gene name solute carrier family 2 (facilitated glucose transporter), member 12
Gene symbol SLC2A12
Other names/aliases GLUT12
GLUT8
Species Homo sapiens
 Database cross references - SLC2A12
ExoCarta ExoCarta_154091
Entrez Gene 154091
HGNC 18067
MIM 610372
UniProt Q8TD20  
 SLC2A12 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC2A12
Molecular Function
    glucose transmembrane transporter activity GO:0005355 IBA
    sugar:proton symporter activity GO:0005351 IBA
Biological Process
    transmembrane transport GO:0055085 TAS
    glucose import GO:0046323 IBA
    proton transport GO:0015992 IBA
    hexose transmembrane transport GO:0035428 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 IBA
    endomembrane system GO:0012505 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified SLC2A12 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC2A12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC2A12 is involved
PathwayEvidenceSource
Facilitative Na+-independent glucose transporters TAS Reactome





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