Gene description for ABCB8
Gene name ATP-binding cassette, sub-family B (MDR/TAP), member 8
Gene symbol ABCB8
Other names/aliases EST328128
M-ABC1
MABC1
Species Homo sapiens
 Database cross references - ABCB8
ExoCarta ExoCarta_11194
Vesiclepedia VP_11194
Entrez Gene 11194
HGNC 49
MIM 605464
UniProt Q9NUT2  
 ABCB8 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ABCB8
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
Biological Process
    cell volume homeostasis GO:0006884 IDA
    peptide transport GO:0015833 IEA
    transmembrane transport GO:0055085 IBA
    potassium ion transmembrane transport GO:0071805 IDA
    mitochondrial potassium ion transmembrane transport GO:0140141 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    membrane GO:0016020 IBA
    mitochondrial membrane GO:0031966 IDA
    ATP-binding cassette (ABC) transporter complex GO:0043190 TAS
    mitochondrial ATP-gated potassium channel complex GO:0062157 IDA
    mitochondrial ATP-gated potassium channel complex GO:0062157 IPI
 Experiment description of studies that identified ABCB8 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ABCB8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GABRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 FMNL1 752
Affinity Capture-MS Homo sapiens
5 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LDHAL6B 92483
Co-fractionation Homo sapiens
7 CXCR4 7852
Affinity Capture-MS Homo sapiens
8 TSPAN15 23555
Affinity Capture-MS Homo sapiens
9 GPR17 2840
Affinity Capture-MS Homo sapiens
10 SLC22A2 6582
Affinity Capture-MS Homo sapiens
11 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 GPR12  
Affinity Capture-MS Homo sapiens
13 VSIG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SLC26A6 65010
Affinity Capture-MS Homo sapiens
16 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
17 HS2ST1 9653
Affinity Capture-MS Homo sapiens
18 SLC1A5 6510
Affinity Capture-MS Homo sapiens
19 KLRK1  
Affinity Capture-MS Homo sapiens
20 FPR1  
Affinity Capture-MS Homo sapiens
21 C19orf38  
Affinity Capture-MS Homo sapiens
22 ADPGK 83440
Co-fractionation Homo sapiens
23 NIPAL1  
Affinity Capture-MS Homo sapiens
24 MTERF3  
Co-fractionation Homo sapiens
25 GPR114  
Affinity Capture-MS Homo sapiens
26 SCN3B  
Affinity Capture-MS Homo sapiens
27 AQP3  
Affinity Capture-MS Homo sapiens
28 P2RY8  
Affinity Capture-MS Homo sapiens
29 LPAR1 1902
Affinity Capture-MS Homo sapiens
30 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CD80 941
Affinity Capture-MS Homo sapiens
32 SLC18A2  
Affinity Capture-MS Homo sapiens
33 VIPR2  
Affinity Capture-MS Homo sapiens
34 SLC5A4  
Affinity Capture-MS Homo sapiens
35 LRCH1 23143
Affinity Capture-MS Homo sapiens
36 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GPR45  
Affinity Capture-MS Homo sapiens
38 CMTM5  
Affinity Capture-MS Homo sapiens
39 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
40 GPR182  
Affinity Capture-MS Homo sapiens
41 STS 412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 IMPAD1 54928
Co-fractionation Homo sapiens
43 VIPR1  
Affinity Capture-MS Homo sapiens
44 B3GAT3 26229
Affinity Capture-MS Homo sapiens
45 RASGRP1  
Co-fractionation Homo sapiens
46 GPR37  
Affinity Capture-MS Homo sapiens
47 SLC31A1 1317
Affinity Capture-MS Homo sapiens
48 RAB11FIP5 26056
Co-fractionation Homo sapiens
49 SLC22A4 6583
Affinity Capture-MS Homo sapiens
50 PROCR 10544
Co-fractionation Homo sapiens
51 SAT1  
Two-hybrid Homo sapiens
52 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SLC22A9  
Affinity Capture-MS Homo sapiens
54 AVPR2  
Affinity Capture-MS Homo sapiens
55 ATP2A1 487
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here