Gene description for SLCO4C1
Gene name solute carrier organic anion transporter family, member 4C1
Gene symbol SLCO4C1
Other names/aliases OATP-H
OATP-M1
OATP4C1
OATPX
PRO2176
SLC21A20
Species Homo sapiens
 Database cross references - SLCO4C1
ExoCarta ExoCarta_353189
Entrez Gene 353189
HGNC 23612
MIM 609013
UniProt Q6ZQN7  
 SLCO4C1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 19056867    
 Gene ontology annotations for SLCO4C1
Molecular Function
    transporter activity GO:0005215 IEA
Biological Process
    spermatogenesis GO:0007283 IEA
    cell differentiation GO:0030154 IEA
    sodium-independent organic anion transport GO:0043252 TAS
    transmembrane transport GO:0055085 TAS
    multicellular organismal development GO:0007275 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
    basolateral plasma membrane GO:0016323 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLCO4C1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLCO4C1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLCO4C1 is involved
PathwayEvidenceSource
Transport of organic anions TAS Reactome





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