Gene description for ATP12A
Gene name ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Gene symbol ATP12A
Other names/aliases ATP1AL1
Species Homo sapiens
 Database cross references - ATP12A
ExoCarta ExoCarta_479
Vesiclepedia VP_479
Entrez Gene 479
HGNC 13816
MIM 182360
UniProt P54707  
 ATP12A identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ATP12A
Molecular Function
    P-type sodium:potassium-exchanging transporter activity GO:0005391 IBA
    P-type sodium:potassium-exchanging transporter activity GO:0005391 IDA
    ATP binding GO:0005524 IEA
    P-type potassium:proton transporter activity GO:0008900 IDA
    ATP hydrolysis activity GO:0016887 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    intracellular sodium ion homeostasis GO:0006883 IBA
    regulation of pH GO:0006885 IEA
    establishment or maintenance of transmembrane electrochemical gradient GO:0010248 IEA
    intracellular potassium ion homeostasis GO:0030007 IBA
    sodium ion export across plasma membrane GO:0036376 IBA
    proton transmembrane transport GO:1902600 IBA
    potassium ion import across plasma membrane GO:1990573 IBA
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    potassium:proton exchanging ATPase complex GO:0005889 TAS
    actin cytoskeleton GO:0015629 IDA
    basolateral plasma membrane GO:0016323 IEA
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified ATP12A in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP12A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 RNF149 284996
Affinity Capture-MS Homo sapiens
3 KLRC4  
Affinity Capture-MS Homo sapiens
4 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 C5AR1  
Affinity Capture-MS Homo sapiens
6 UPK2 7379
Affinity Capture-MS Homo sapiens
7 DHCR24 1718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MME 4311
Affinity Capture-MS Homo sapiens
10 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 HCRTR2  
Affinity Capture-MS Homo sapiens
12 FPR1  
Affinity Capture-MS Homo sapiens
13 HS3ST4  
Affinity Capture-MS Homo sapiens
14 KLRB1  
Affinity Capture-MS Homo sapiens
15 NDUFA4 4697
Affinity Capture-MS Homo sapiens
16 OR10G2  
Affinity Capture-MS Homo sapiens
17 FAXC  
Affinity Capture-MS Homo sapiens
18 FFAR1  
Affinity Capture-MS Homo sapiens
19 PDE2A  
Affinity Capture-MS Homo sapiens
20 ATP1A1 476
Cross-Linking-MS (XL-MS) Homo sapiens
21 MRFAP1L1  
Affinity Capture-MS Homo sapiens
22 CTDSP2 10106
Affinity Capture-MS Homo sapiens
23 FIS1 51024
Affinity Capture-MS Homo sapiens
24 VIPR2  
Affinity Capture-MS Homo sapiens
25 SLC26A4 5172
Affinity Capture-MS Homo sapiens
26 CYB5B 80777
Affinity Capture-MS Homo sapiens
27 SPPL2B 56928
Affinity Capture-MS Homo sapiens
28 CHODL 140578
Affinity Capture-MS Homo sapiens
29 HLA-B 3106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 GPR88  
Affinity Capture-MS Homo sapiens
32 TMED2 10959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 TIMM23 100287932
Affinity Capture-MS Homo sapiens
34 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ITM2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 JTB 10899
Affinity Capture-MS Homo sapiens
37 ENSA 2029
Affinity Capture-MS Homo sapiens
38 AGTR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 GAL3ST2  
Affinity Capture-MS Homo sapiens
40 DGCR2 9993
Affinity Capture-MS Homo sapiens
41 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 UGT1A4  
Affinity Capture-MS Homo sapiens
43 NAT8B  
Affinity Capture-MS Homo sapiens
44 KLRC2  
Affinity Capture-MS Homo sapiens
45 KCNMB3  
Affinity Capture-MS Homo sapiens
46 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 IFNLR1  
Affinity Capture-MS Homo sapiens
48 WFDC11  
Affinity Capture-MS Homo sapiens
49 CD3D 915
Affinity Capture-MS Homo sapiens
50 PTH1R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SLC25A3 5250
Affinity Capture-MS Homo sapiens
52 ATP1A3 478
Cross-Linking-MS (XL-MS) Homo sapiens
53 AGPAT2  
Affinity Capture-MS Homo sapiens
54 P2RY8  
Affinity Capture-MS Homo sapiens
55 P2RY14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 GZMH  
Affinity Capture-MS Homo sapiens
57 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
58 PPIB 5479
Two-hybrid Homo sapiens
59 EFNA5  
Affinity Capture-MS Homo sapiens
60 HS2ST1 9653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CX3CL1  
Affinity Capture-MS Homo sapiens
62 GCGR  
Affinity Capture-MS Homo sapiens
63 ST3GAL1 6482
Affinity Capture-MS Homo sapiens
64 CEP41  
Affinity Capture-MS Homo sapiens
65 HCST  
Affinity Capture-MS Homo sapiens
66 WBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 NPHS1 4868
Affinity Capture-MS Homo sapiens
68 AGK 55750
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 LYZL6  
Affinity Capture-MS Homo sapiens
70 RNF115  
Affinity Capture-MS Homo sapiens
71 VSIG4  
Affinity Capture-MS Homo sapiens
72 KRTCAP3 200634
Affinity Capture-MS Homo sapiens
73 PILRB 29990
Affinity Capture-MS Homo sapiens
74 CD300C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 IL2RA  
Affinity Capture-MS Homo sapiens
76 TUSC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ODF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 S1PR1 1901
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 NPY  
Two-hybrid Homo sapiens
80 NUDT16 131870
Affinity Capture-MS Homo sapiens
81 SLC2A5 6518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 TNFRSF10C  
Affinity Capture-MS Homo sapiens
83 LAGE3  
Affinity Capture-MS Homo sapiens
84 UPK1A 11045
Affinity Capture-MS Homo sapiens
85 PRND  
Affinity Capture-MS Homo sapiens
86 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 GRIN2C 2905
Affinity Capture-MS Homo sapiens
88 MLNR  
Affinity Capture-MS Homo sapiens
89 CLRN2  
Affinity Capture-MS Homo sapiens
90 NKAIN1  
Affinity Capture-MS Homo sapiens
91 C7orf34  
Affinity Capture-MS Homo sapiens
92 P2RY2 5029
Affinity Capture-MS Homo sapiens
93 NTRK1 4914
Affinity Capture-MS Homo sapiens
94 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RARS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 APLNR  
Affinity Capture-MS Homo sapiens
97 F2RL1  
Affinity Capture-MS Homo sapiens
98 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 AGPAT1 10554
Affinity Capture-MS Homo sapiens
100 ZFPL1 7542
Affinity Capture-MS Homo sapiens
101 NT5C1A  
Affinity Capture-MS Homo sapiens
102 RTP2  
Affinity Capture-MS Homo sapiens
103 TYROBP  
Affinity Capture-MS Homo sapiens
104 TMEM223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 GPR182  
Affinity Capture-MS Homo sapiens
106 MGARP  
Affinity Capture-MS Homo sapiens
107 PCP4  
Affinity Capture-MS Homo sapiens
108 GPR12  
Affinity Capture-MS Homo sapiens
109 NIPAL1  
Affinity Capture-MS Homo sapiens
110 FXYD6  
Affinity Capture-MS Homo sapiens
111 ATP1B3 483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 OPRL1 4987
Affinity Capture-MS Homo sapiens
113 ACKR4  
Affinity Capture-MS Homo sapiens
114 CD226 10666
Affinity Capture-MS Homo sapiens
115 MYCN  
Affinity Capture-MS Homo sapiens
116 SMDT1  
Affinity Capture-MS Homo sapiens
117 C1QB 713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 CHRNB4  
Affinity Capture-MS Homo sapiens
119 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 RAB2B 84932
Affinity Capture-MS Homo sapiens
121 B3GNT7  
Affinity Capture-MS Homo sapiens
122 ART3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 ACKR2  
Affinity Capture-MS Homo sapiens
124 SARAF  
Affinity Capture-MS Homo sapiens
125 TRABD 80305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 ATP1B1 481
Affinity Capture-MS Homo sapiens
127 SLC22A15  
Affinity Capture-MS Homo sapiens
128 NTSR1  
Affinity Capture-MS Homo sapiens
129 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
130 GPR84  
Affinity Capture-MS Homo sapiens
131 SLC37A4 2542
Affinity Capture-MS Homo sapiens
132 PTAFR  
Affinity Capture-MS Homo sapiens
133 TSPAN10 83882
Affinity Capture-MS Homo sapiens
134 SLC37A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 GPR17 2840
Affinity Capture-MS Homo sapiens
136 FEZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 FCGR3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 HSD17B6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 SLC25A6 293
Affinity Capture-MS Homo sapiens
141 CTDSP1 58190
Affinity Capture-MS Homo sapiens
142 CSNK1A1L 122011
Affinity Capture-MS Homo sapiens
143 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 CCR1  
Affinity Capture-MS Homo sapiens
145 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 SLAMF1 6504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 KLHL11  
Affinity Capture-MS Homo sapiens
148 AUP1 550
Affinity Capture-MS Homo sapiens
149 LPCAT2 54947
Affinity Capture-MS Homo sapiens
150 NAA30 122830
Affinity Capture-MS Homo sapiens
151 PLD3 23646
Affinity Capture-MS Homo sapiens
152 BRICD5  
Affinity Capture-MS Homo sapiens
153 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 SPCS1 28972
Affinity Capture-MS Homo sapiens
155 SEC62 7095
Affinity Capture-MS Homo sapiens
156 ADORA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
158 PINK1  
Affinity Capture-MS Homo sapiens
159 TREM1 54210
Affinity Capture-MS Homo sapiens
160 GP5 2814
Affinity Capture-MS Homo sapiens
161 TNFRSF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 TPST2 8459
Affinity Capture-MS Homo sapiens
163 KIR2DL4  
Affinity Capture-MS Homo sapiens
164 VIPR1  
Affinity Capture-MS Homo sapiens
165 PTGFR 5737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 GNAI3 2773
Two-hybrid Homo sapiens
167 CCR6  
Affinity Capture-MS Homo sapiens
168 IRGC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
170 PCDHGA7 56108
Affinity Capture-MS Homo sapiens
171 PLD6  
Affinity Capture-MS Homo sapiens
172 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 FPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 CXCL16 58191
Affinity Capture-MS Homo sapiens
175 S1PR4  
Affinity Capture-MS Homo sapiens
176 DKKL1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ATP12A is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Transport of small molecules TAS Reactome





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