Gene description for ST3GAL1
Gene name ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene symbol ST3GAL1
Other names/aliases Gal-NAc6S
SIAT4A
SIATFL
ST3GalA
ST3GalA.1
ST3GalIA
ST3GalIA,1
ST3O
Species Homo sapiens
 Database cross references - ST3GAL1
ExoCarta ExoCarta_6482
Vesiclepedia VP_6482
Entrez Gene 6482
HGNC 10862
MIM 607187
UniProt Q11201  
 ST3GAL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Saliva 19199708    
 Gene ontology annotations for ST3GAL1
Molecular Function
    beta-galactoside (CMP) alpha-2,3-sialyltransferase activity GO:0003836 IBA
    beta-galactoside (CMP) alpha-2,3-sialyltransferase activity GO:0003836 IDA
    beta-galactoside (CMP) alpha-2,3-sialyltransferase activity GO:0003836 ISS
    beta-galactoside (CMP) alpha-2,3-sialyltransferase activity GO:0003836 TAS
    sialyltransferase activity GO:0008373 TAS
    beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase GO:0047288 IEA
Biological Process
    memory B cell differentiation GO:0002319 IEA
    N-acetylneuraminate metabolic process GO:0006054 ISS
    protein glycosylation GO:0006486 IBA
    protein N-linked glycosylation GO:0006487 ISS
    ganglioside biosynthetic process via lactosylceramide GO:0010706 IBA
    ganglioside biosynthetic process via lactosylceramide GO:0010706 IDA
    O-glycan processing GO:0016266 TAS
    keratan sulfate biosynthetic process GO:0018146 TAS
    viral protein processing GO:0019082 TAS
    protein modification process GO:0036211 TAS
    sialylation GO:0097503 IBA
    sialylation GO:0097503 ISS
    negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process GO:1905403 IEA
    protein sialylation GO:1990743 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
    trans-Golgi network membrane GO:0032588 IDA
    extracellular exosome GO:0070062 HDA
    Golgi medial cisterna membrane GO:1990675 IDA
    Golgi trans cisterna membrane GO:1990676 IDA
 Experiment description of studies that identified ST3GAL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for ST3GAL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STARD3NL 83930
Affinity Capture-MS Homo sapiens
2 PSEN1 5663
Affinity Capture-MS Homo sapiens
3 CANX 821
Affinity Capture-MS Homo sapiens
4 ATP1A3 478
Affinity Capture-MS Homo sapiens
5 GSTA1 2938
Two-hybrid Homo sapiens
6 GPR89B 51463
Affinity Capture-MS Homo sapiens
7 ATP12A 479
Affinity Capture-MS Homo sapiens
8 TRAF6 7189
Affinity Capture-MS Homo sapiens
9 ERLEC1 27248
Affinity Capture-MS Homo sapiens
10 GOLPH3 64083
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RMND1 55005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LMBR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ASPHD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 APEX1 328
Affinity Capture-RNA Homo sapiens
15 ITGAV 3685
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SLC39A10 57181
Affinity Capture-MS Homo sapiens
17 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SLC39A11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SLC30A7 148867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 C6orf120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 METTL9 51108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ANKRD46 157567
Affinity Capture-MS Homo sapiens
23 UBE2J1 51465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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