Gene description for ST3GAL1
Gene name ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene symbol ST3GAL1
Other names/aliases Gal-NAc6S
SIAT4A
SIATFL
ST3GalA
ST3GalA.1
ST3GalIA
ST3GalIA,1
ST3O
Species Homo sapiens
 Database cross references - ST3GAL1
ExoCarta ExoCarta_6482
Entrez Gene 6482
HGNC 10862
MIM 607187
UniProt Q11201  
 ST3GAL1 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for ST3GAL1
Molecular Function
    beta-galactoside (CMP) alpha-2,3-sialyltransferase activity GO:0003836 ISS
Biological Process
    post-translational protein modification GO:0043687 TAS
    cellular protein modification process GO:0006464 TAS
    N-acetylneuraminate metabolic process GO:0006054 ISS
    protein O-linked glycosylation GO:0006493 TAS
    keratan sulfate metabolic process GO:0042339 TAS
    O-glycan processing GO:0016266 TAS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    small molecule metabolic process GO:0044281 TAS
    protein N-linked glycosylation GO:0006487 ISS
    protein phosphorylation GO:0006468 IEA
    keratan sulfate biosynthetic process GO:0018146 TAS
    sialylation GO:0097503 ISS
    carbohydrate metabolic process GO:0005975 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    dolichol-linked oligosaccharide biosynthetic process GO:0006488 TAS
    cellular protein metabolic process GO:0044267 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of Golgi membrane GO:0030173 IEA
    Golgi cisterna membrane GO:0032580 IEA
    membrane GO:0016020 IDA
    Golgi membrane GO:0000139 TAS
 Experiment description of studies that identified ST3GAL1 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for ST3GAL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ST3GAL1 is involved
PathwayEvidenceSource
Keratan sulfate biosynthesis TAS Reactome
Sialic acid metabolism TAS Reactome
Termination of O-glycan biosynthesis TAS Reactome





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