Gene description for STARD3NL
Gene name STARD3 N-terminal like
Gene symbol STARD3NL
Other names/aliases MENTHO
Species Homo sapiens
 Database cross references - STARD3NL
ExoCarta ExoCarta_83930
Vesiclepedia VP_83930
Entrez Gene 83930
HGNC 19169
MIM 611759
UniProt O95772  
 STARD3NL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for STARD3NL
Molecular Function
    protein binding GO:0005515 IPI
    cholesterol binding GO:0015485 IBA
    cholesterol binding GO:0015485 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    cholesterol transport GO:0030301 IBA
    vesicle tethering to endoplasmic reticulum GO:0099044 IBA
    vesicle tethering to endoplasmic reticulum GO:0099044 IDA
Subcellular Localization
    lysosomal membrane GO:0005765 HDA
    endosome GO:0005768 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    late endosome membrane GO:0031902 IBA
    late endosome membrane GO:0031902 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    organelle membrane contact site GO:0044232 IDA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IBA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IDA
 Experiment description of studies that identified STARD3NL in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for STARD3NL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC4A2 6522
Affinity Capture-MS Homo sapiens
2 NDUFAF1  
Affinity Capture-MS Homo sapiens
3 ERGIC3 51614
Affinity Capture-MS Homo sapiens
4 SLC25A40  
Affinity Capture-MS Homo sapiens
5 AGPAT5 55326
Affinity Capture-MS Homo sapiens
6 ATP13A3 79572
Affinity Capture-MS Homo sapiens
7 TMEM106B 54664
Affinity Capture-MS Homo sapiens
8 GPAA1 8733
Affinity Capture-MS Homo sapiens
9 MBOAT7 79143
Affinity Capture-MS Homo sapiens
10 ATP5J 522
Affinity Capture-MS Homo sapiens
11 FASTKD1  
Affinity Capture-MS Homo sapiens
12 GPR108 56927
Affinity Capture-MS Homo sapiens
13 TNFSF8  
Affinity Capture-MS Homo sapiens
14 KIAA2013 90231
Affinity Capture-MS Homo sapiens
15 CYP2S1  
Affinity Capture-MS Homo sapiens
16 POMGNT1 55624
Affinity Capture-MS Homo sapiens
17 ENDOD1 23052
Affinity Capture-MS Homo sapiens
18 ATP5F1 515
Affinity Capture-MS Homo sapiens
19 ST3GAL1 6482
Affinity Capture-MS Homo sapiens
20 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
21 LNPEP 4012
Affinity Capture-MS Homo sapiens
22 INTS1 26173
Affinity Capture-MS Homo sapiens
23 STOM 2040
Affinity Capture-MS Homo sapiens
24 P2RY8  
Affinity Capture-MS Homo sapiens
25 LPAR1 1902
Affinity Capture-MS Homo sapiens
26 TOMM22 56993
Co-fractionation Homo sapiens
27 GPR35  
Affinity Capture-MS Homo sapiens
28 AMY1C 278
Affinity Capture-MS Homo sapiens
29 AGPAT6 137964
Affinity Capture-MS Homo sapiens
30 ELK1  
Two-hybrid Homo sapiens
31 ERGIC2 51290
Affinity Capture-MS Homo sapiens
32 PTDSS2 81490
Affinity Capture-MS Homo sapiens
33 GP5 2814
Affinity Capture-MS Homo sapiens
34 SLC25A4 291
Affinity Capture-MS Homo sapiens
35 SYNJ2BP 55333
Co-fractionation Homo sapiens
36 ATP9A 10079
Affinity Capture-MS Homo sapiens
37 CHRM5  
Two-hybrid Homo sapiens
38 LPAR2 9170
Affinity Capture-MS Homo sapiens
39 TMEM231 79583
Affinity Capture-MS Homo sapiens
40 MOSPD2 158747
Affinity Capture-MS Homo sapiens
41 SLC6A5  
Affinity Capture-MS Homo sapiens
42 WFS1 7466
Affinity Capture-MS Homo sapiens
43 KLRC1  
Affinity Capture-MS Homo sapiens
44 CD63 967
Affinity Capture-MS Homo sapiens
45 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
46 SLC25A19  
Affinity Capture-MS Homo sapiens
47 PIGS 94005
Affinity Capture-MS Homo sapiens
48 LPGAT1 9926
Affinity Capture-MS Homo sapiens
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