Gene description for ENDOD1
Gene name endonuclease domain containing 1
Gene symbol ENDOD1
Other names/aliases -
Species Homo sapiens
 Database cross references - ENDOD1
ExoCarta ExoCarta_23052
Vesiclepedia VP_23052
Entrez Gene 23052
HGNC 29129
UniProt O94919  
 ENDOD1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ENDOD1
Molecular Function
    nucleic acid binding GO:0003676 IEA
    endonuclease activity GO:0004519 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    innate immune response GO:0045087 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ENDOD1 in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ENDOD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STARD3NL 83930
Affinity Capture-MS Homo sapiens
2 SSMEM1  
Affinity Capture-MS Homo sapiens
3 STRIP1 85369
Affinity Capture-MS Homo sapiens
4 NKAIN4  
Affinity Capture-MS Homo sapiens
5 SLC43A3 29015
Affinity Capture-MS Homo sapiens
6 MARCH3 115123
Affinity Capture-MS Homo sapiens
7 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 FASN 2194
Positive Genetic Homo sapiens
10 RALY 22913
Cross-Linking-MS (XL-MS) Homo sapiens
11 HSP90B2P  
Cross-Linking-MS (XL-MS) Homo sapiens
12 GPR141  
Affinity Capture-MS Homo sapiens
13 TACR1  
Affinity Capture-MS Homo sapiens
14 DHCR24 1718
Affinity Capture-MS Homo sapiens
15 SLC31A2  
Affinity Capture-MS Homo sapiens
16 KIF21A 55605
Affinity Capture-MS Homo sapiens
17 KMT2A  
Cross-Linking-MS (XL-MS) Homo sapiens
18 ARRDC5  
Affinity Capture-MS Homo sapiens
19 VSNL1 7447
Two-hybrid Homo sapiens
20 LAMTOR1 55004
Affinity Capture-MS Homo sapiens
21 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
22 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HMOX2 3163
Affinity Capture-MS Homo sapiens
25 TMEM184A  
Affinity Capture-MS Homo sapiens
26 SREBF1 6720
Negative Genetic Homo sapiens
27 GOLT1B 51026
Affinity Capture-MS Homo sapiens
28 RTN4 57142
Affinity Capture-MS Homo sapiens
29 BSCL2  
Affinity Capture-MS Homo sapiens
30 PLEKHM3 389072
Affinity Capture-MS Homo sapiens
31 STRN3 29966
Affinity Capture-MS Homo sapiens
32 MFSD8 256471
Affinity Capture-MS Homo sapiens
33 SLC34A2 10568
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SLC19A2 10560
Affinity Capture-MS Homo sapiens
35 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TSPAN16  
Affinity Capture-MS Homo sapiens
37 REEP2  
Affinity Capture-MS Homo sapiens
38 TMEM72  
Affinity Capture-MS Homo sapiens
39 SHMT2 6472
Affinity Capture-RNA Homo sapiens
40 TMEM159 57146
Affinity Capture-MS Homo sapiens
41 C5AR1  
Affinity Capture-MS Homo sapiens
42 SEC62 7095
Affinity Capture-MS Homo sapiens
43 SOX2  
Affinity Capture-MS Homo sapiens
44 FNDC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 NXF1 10482
Affinity Capture-RNA Homo sapiens
46 VAPA 9218
Affinity Capture-MS Homo sapiens
47 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TMEM43 79188
Affinity Capture-MS Homo sapiens
49 RAET1L  
Affinity Capture-MS Homo sapiens
50 CTDSP2 10106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 Dicer1  
Affinity Capture-MS Mus musculus
52 MOV10 4343
Affinity Capture-RNA Homo sapiens
53 CYB5A 1528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 STRN 6801
Affinity Capture-MS Homo sapiens
55 Uso1 56041
Affinity Capture-MS Mus musculus
56 REEP1  
Affinity Capture-MS Homo sapiens
57 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 AGPAT3 56894
Affinity Capture-MS Homo sapiens
59 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
60 ACKR2  
Affinity Capture-MS Homo sapiens
61 COPB2 9276
Affinity Capture-MS Homo sapiens
62 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
63 EDNRA 1909
Affinity Capture-MS Homo sapiens
64 STOM 2040
Affinity Capture-MS Homo sapiens
65 SMPD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 TNFRSF10C  
Affinity Capture-MS Homo sapiens
67 ENO1 2023
Affinity Capture-RNA Homo sapiens
68 P2RY2 5029
Affinity Capture-MS Homo sapiens
69 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 RNF26  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
71 RER1 11079
Affinity Capture-MS Homo sapiens
72 COG7 91949
Affinity Capture-MS Homo sapiens
73 CAV1 857
Affinity Capture-MS Homo sapiens
74 FFAR1  
Affinity Capture-MS Homo sapiens
75 SUN2 25777
Affinity Capture-MS Homo sapiens
76 C20orf141  
Affinity Capture-MS Homo sapiens
77 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml



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