Gene description for CAV3
Gene name caveolin 3
Gene symbol CAV3
Other names/aliases LGMD1C
LQT9
VIP-21
VIP21
Species Homo sapiens
 Database cross references - CAV3
ExoCarta ExoCarta_859
Vesiclepedia VP_859
Entrez Gene 859
HGNC 1529
MIM 601253
UniProt P56539  
 CAV3 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CAV3
Molecular Function
    ion channel binding GO:0044325 IPI
    protein complex scaffold GO:0032947 ISS
    potassium channel inhibitor activity GO:0019870 ISS
    sodium channel regulator activity GO:0017080 IMP
    protein binding GO:0005515 IPI
    connexin binding GO:0071253 IDA
    alpha-tubulin binding GO:0043014 IEA
    protein C-terminus binding GO:0008022 IDA
    nitric-oxide synthase binding GO:0050998 IEA
    calcium channel regulator activity GO:0005246 IDA
    protein complex binding GO:0032403 IDA
Biological Process
    regulation of p38MAPK cascade GO:1900744 IEA
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 NAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    muscle organ development GO:0007517 TAS
    positive regulation of microtubule polymerization GO:0031116 ISS
    regulation of cardiac muscle contraction GO:0055117 IMP
    protein localization GO:0008104 ISS
    caveola assembly GO:0070836 IDA
    negative regulation of calcium ion transport GO:0051926 IDA
    regulation of protein kinase B signaling GO:0051896 IEA
    plasma membrane repair GO:0001778 IEA
    cytoplasmic microtubule organization GO:0031122 IEA
    regulation of signal transduction by receptor internalization GO:0038009 IMP
    regulation of membrane potential GO:0042391 IDA
    regulation of calcium ion import GO:0090279 IDA
    triglyceride metabolic process GO:0006641 ISS
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISS
    glucose homeostasis GO:0042593 ISS
    plasma membrane organization GO:0007009 ISS
    negative regulation of cardiac muscle hypertrophy GO:0010614 IMP
    regulation of heart rate GO:0002027 IMP
    regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 IMP
    T-tubule organization GO:0033292 TAS
    myoblast fusion GO:0007520 IEA
    negative regulation of sarcomere organization GO:0060299 IMP
    protein localization to plasma membrane GO:0072659 ISS
    membrane raft organization GO:0031579 ISS
    negative regulation of potassium ion transmembrane transport GO:1901380 ISS
    heart trabecula formation GO:0060347 IEA
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 IEA
    cholesterol homeostasis GO:0042632 ISS
    negative regulation of MAP kinase activity GO:0043407 IMP
    muscle cell cellular homeostasis GO:0046716 ISS
    actin filament organization GO:0007015 IEA
    cardiac muscle cell development GO:0055013 IEA
    ventricular cardiac muscle cell action potential GO:0086005 ISS
    negative regulation of protein kinase activity GO:0006469 ISS
    nucleus localization GO:0051647 IEA
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IEA
    regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 IDA
    positive regulation of cell proliferation GO:0008284 IEA
    negative regulation of cell size GO:0045792 IMP
    cell differentiation GO:0030154 ISS
    positive regulation of caveolin-mediated endocytosis GO:2001288 IEA
    regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IEA
    regulation of sodium ion transmembrane transporter activity GO:2000649 IDA
    endocytosis GO:0006897 ISS
    regulation of heart contraction GO:0008016 ISS
    regulation of calcium ion transmembrane transporter activity GO:1901019 IDA
    positive regulation of myotube differentiation GO:0010831 IEA
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 IMP
    cell growth GO:0016049 ISS
    regulation of nerve growth factor receptor activity GO:0051394 IMP
    establishment of protein localization to plasma membrane GO:0090002 IEA
    regulation of skeletal muscle contraction GO:0014819 IMP
    negative regulation of protein localization to cell surface GO:2000009 NAS
    negative regulation of MAPK cascade GO:0043409 ISS
    negative regulation of nitric-oxide synthase activity GO:0051001 ISS
Subcellular Localization
    intercalated disc GO:0014704 IEA
    Z disc GO:0030018 ISS
    neuromuscular junction GO:0031594 ISS
    vesicle GO:0031982 IEA
    dystrophin-associated glycoprotein complex GO:0016010 IDA
    sarcolemma GO:0042383 IDA
    endoplasmic reticulum GO:0005783 IDA
    membrane raft GO:0045121 ISS
    cytosol GO:0005829 ISS
    Golgi membrane GO:0000139 IEA
    cell surface GO:0009986 IEA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IEA
    T-tubule GO:0030315 ISS
 Experiment description of studies that identified CAV3 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CAV3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PFKM 5213
Invivo Homo sapiens
Invitro Homo sapiens
2 SLC8A1 6546
Affinity Capture-Western Homo sapiens
3 JPH2 57158
Affinity Capture-Western Homo sapiens
4 GNAS 2778
Invitro Homo sapiens
5 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
6 DYSF 8291
Invivo Homo sapiens
Invitro Homo sapiens
7 NOS1  
Invitro Homo sapiens
8 DAG1 1605
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CAV3 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome





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