Gene description for CAV3
Gene name caveolin 3
Gene symbol CAV3
Other names/aliases LGMD1C
LQT9
VIP-21
VIP21
Species Homo sapiens
 Database cross references - CAV3
ExoCarta ExoCarta_859
Vesiclepedia VP_859
Entrez Gene 859
HGNC 1529
MIM 601253
UniProt P56539  
 CAV3 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CAV3
Molecular Function
    calcium channel regulator activity GO:0005246 IDA
    protein binding GO:0005515 IPI
    sodium channel regulator activity GO:0017080 IDA
    sodium channel regulator activity GO:0017080 IMP
    potassium channel inhibitor activity GO:0019870 ISS
    alpha-tubulin binding GO:0043014 IEA
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IPI
    protein-containing complex binding GO:0044877 IDA
    nitric-oxide synthase binding GO:0050998 IEA
    molecular adaptor activity GO:0060090 IBA
    molecular adaptor activity GO:0060090 IPI
    connexin binding GO:0071253 IDA
Biological Process
    MAPK cascade GO:0000165 IEA
    response to hypoxia GO:0001666 IEA
    plasma membrane repair GO:0001778 IEA
    regulation of heart rate GO:0002027 IMP
    response to ischemia GO:0002931 IEA
    cardiac muscle hypertrophy GO:0003300 IEA
    triglyceride metabolic process GO:0006641 ISS
    calcium ion transport GO:0006816 IEA
    endocytosis GO:0006897 ISS
    plasma membrane organization GO:0007009 ISS
    actin filament organization GO:0007015 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    muscle organ development GO:0007517 TAS
    myoblast fusion GO:0007520 IEA
    regulation of heart contraction GO:0008016 IMP
    protein localization GO:0008104 ISS
    positive regulation of cell population proliferation GO:0008284 IEA
    negative regulation of cardiac muscle hypertrophy GO:0010614 IMP
    positive regulation of myotube differentiation GO:0010831 IEA
    regulation of skeletal muscle contraction GO:0014819 IMP
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IEA
    cell differentiation GO:0030154 IBA
    cell differentiation GO:0030154 ISS
    positive regulation of microtubule polymerization GO:0031116 ISS
    cytoplasmic microtubule organization GO:0031122 IEA
    membrane raft organization GO:0031579 ISS
    T-tubule organization GO:0033292 TAS
    detection of muscle stretch GO:0035995 ISS
    regulation of signal transduction by receptor internalization GO:0038009 IMP
    regulation of membrane potential GO:0042391 IBA
    regulation of membrane potential GO:0042391 IDA
    glucose homeostasis GO:0042593 ISS
    cholesterol homeostasis GO:0042632 ISS
    negative regulation of MAPK cascade GO:0043409 IMP
    negative regulation of MAPK cascade GO:0043409 ISS
    negative regulation of cell size GO:0045792 IMP
    regulation of nerve growth factor receptor activity GO:0051394 IMP
    regulation of cytosolic calcium ion concentration GO:0051480 IBA
    nucleus localization GO:0051647 IEA
    establishment of localization in cell GO:0051649 IEA
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IEA
    negative regulation of calcium ion transport GO:0051926 IDA
    cardiac muscle cell development GO:0055013 IEA
    regulation of cardiac muscle contraction GO:0055117 IMP
    negative regulation of sarcomere organization GO:0060299 IMP
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 IMP
    heart trabecula formation GO:0060347 IEA
    regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 IDA
    regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IEA
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 IEA
    caveola assembly GO:0070836 IBA
    caveola assembly GO:0070836 IDA
    protein localization to plasma membrane GO:0072659 ISS
    ventricular cardiac muscle cell action potential GO:0086005 ISS
    regulation of calcium ion import GO:0090279 IDA
    regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 IMP
    regulation of p38MAPK cascade GO:1900744 IEA
    regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 IMP
    negative regulation of membrane depolarization during cardiac muscle cell action potential GO:1900826 IEA
    negative regulation of potassium ion transmembrane transport GO:1901380 ISS
    regulation of sodium ion transmembrane transport GO:1902305 IDA
    negative regulation of protein localization to cell surface GO:2000009 NAS
    positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 NAS
    positive regulation of caveolin-mediated endocytosis GO:2001288 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IBA
    caveola GO:0005901 ISS
    focal adhesion GO:0005925 IBA
    cell surface GO:0009986 IEA
    intercalated disc GO:0014704 IEA
    dystrophin-associated glycoprotein complex GO:0016010 IDA
    Z disc GO:0030018 ISS
    T-tubule GO:0030315 ISS
    neuromuscular junction GO:0031594 ISS
    vesicle GO:0031982 IEA
    sarcolemma GO:0042383 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    membrane raft GO:0045121 ISS
 Experiment description of studies that identified CAV3 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CAV3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANKRD13C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 KCNH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 GTSE1 51512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SLC8A1 6546
Affinity Capture-Western Homo sapiens
5 KIF1B 23095
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SNX3 8724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RBFA  
Two-hybrid Homo sapiens
8 SPRY2 10253
Affinity Capture-MS Homo sapiens
9 MARK2 2011
Affinity Capture-MS Homo sapiens
10 DAG1 1605
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
11 AP1S2 8905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SARM1 23098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PFKM 5213
Affinity Capture-Western Homo sapiens
14 ADRB2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
15 MIS18A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PDGFRA 5156
Reconstituted Complex Homo sapiens
17 ENDOD1 23052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NFRKB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EGFR 1956
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 REEP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 REEP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PDGFRB 5159
Reconstituted Complex Homo sapiens
23 TBC1D2B 23102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 RAI14 26064
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PBX3  
Two-hybrid Homo sapiens
26 SBDS 51119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 KIAA1598 57698
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SUN2 25777
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RABL3 285282
Affinity Capture-MS Homo sapiens
30 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MCM10 55388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TM2D3  
Affinity Capture-MS Homo sapiens
33 PCBP1 5093
Two-hybrid Homo sapiens
34 C21orf2  
Affinity Capture-MS Homo sapiens
35 JPH2 57158
Affinity Capture-Western Homo sapiens
36 REEP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 CEP95  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SENP1  
Biochemical Activity Homo sapiens
39 PTGES3 10728
Two-hybrid Homo sapiens
40 CUL7 9820
Affinity Capture-MS Homo sapiens
41 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CENPT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 OIP5  
Affinity Capture-MS Homo sapiens
44 MIS18BP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PTRF 284119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CAV1 857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 MAP7D3 79649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TOM1L1 10040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SCN5A 6331
Affinity Capture-Western Homo sapiens
50 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 DYSF 8291
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 TULP3 7289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 DMWD  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAV3 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Muscle contraction IEA Reactome
Smooth Muscle Contraction TAS Reactome
Smooth Muscle Contraction IEA Reactome





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