Gene description for MCM10
Gene name minichromosome maintenance complex component 10
Gene symbol MCM10
Other names/aliases CNA43
DNA43
PRO2249
Species Homo sapiens
 Database cross references - MCM10
ExoCarta ExoCarta_55388
Vesiclepedia VP_55388
Entrez Gene 55388
HGNC 18043
MIM 609357
UniProt Q7L590  
 MCM10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MCM10
Molecular Function
    identical protein binding GO:0042802 IPI
    DNA replication origin binding GO:0003688 IBA
    protein binding GO:0005515 IPI
    double-stranded DNA binding GO:0003690 IBA
    single-stranded DNA binding GO:0003697 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    DNA replication initiation GO:0006270 IBA
    mitotic cell cycle GO:0000278 TAS
    DNA replication GO:0006260 TAS
    G1/S transition of mitotic cell cycle GO:0000082 TAS
    cell proliferation GO:0008283 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
    replication fork protection complex GO:0031298 IBA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified MCM10 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MCM10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCM7 4176
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 CDC45L  
Affinity Capture-MS Homo sapiens
3 ORC2L  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
4 NDP52  
Two-hybrid Homo sapiens
5 MCM3 4172
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 KIAA0980  
Two-hybrid Homo sapiens
7 Cep72  
Two-hybrid Homo sapiens
8 CDKN1A  
Affinity Capture-MS Homo sapiens
9 MCM4 4173
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
10 CDK6 1021
Affinity Capture-MS Homo sapiens
11 DPPA2  
Two-hybrid Homo sapiens
12 KRT15 3866
Two-hybrid Homo sapiens
13 TRIM37  
Two-hybrid Homo sapiens
14 Cep70  
Two-hybrid Homo sapiens
15 MCM2 4171
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
16 CCDC5  
Affinity Capture-MS Homo sapiens
17 ORC4L  
Affinity Capture-MS Homo sapiens
18 HOOK2  
Two-hybrid Homo sapiens
19 DIPA  
Two-hybrid Homo sapiens
20 MCM6 4175
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
21 ZBTB8  
Two-hybrid Homo sapiens
22 ZBTB43  
Two-hybrid Homo sapiens
23 CDC5L 988
Affinity Capture-MS Homo sapiens
24 CCND3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
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