Gene description for EIF2B5
Gene name
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
Gene symbol
EIF2B5
Other names/aliases
CACH CLE EIF-2B EIF2Bepsilon LVWM
Species
Homo sapiens
Database cross references - EIF2B5
ExoCarta
ExoCarta_8893
Entrez Gene
8893
HGNC
3261
MIM
603945
UniProt
Q13144
EIF2B5 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells
25944692
Thymus
23844026
Gene ontology annotations for EIF2B5
Experiment description of studies that identified EIF2B5 in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for EIF2B5
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
EIF2B4
8890
Reconstituted Complex
Homo sapiens
2
EIF2B3
8891
Reconstituted Complex
Homo sapiens
3
EIF2B1
1967
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
4
EIF2B2
8892
Reconstituted Complex
Homo sapiens
Reconstituted Complex
Homo sapiens
View the network
image/svg+xml
Pathways in which EIF2B5 is involved