Gene description for CD74
Gene name	CD74 molecule, major histocompatibility complex, class II invariant chain
Gene symbol	CD74
Other names/aliases	DHLAG HLADG II Ia-GAMMA
Species	Homo sapiens
Database cross references - CD74
ExoCarta	ExoCarta_972
Entrez Gene	972
HGNC	1697
MIM	142790
UniProt	P04233
CD74 identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Thymus	23844026

Gene ontology annotations for CD74

Molecular Function     identical protein binding GO:0042802 TAS     cytokine receptor activity GO:0004896 IDA     nitric-oxide synthase binding GO:0050998 IEA     macrophage migration inhibitory factor binding GO:0035718 IPI     MHC class II protein binding, via antigen binding groove GO:0042658 IDA     MHC class II protein binding GO:0042289 NAS     protein binding involved in protein folding GO:0044183 IDA     MHC class II protein complex binding GO:0023026 IDA     beta-amyloid binding GO:0001540 IPI     cytokine binding GO:0019955 IPI     protein binding GO:0005515 IPI Biological Process     positive regulation of type 2 immune response GO:0002830 IEA     immunoglobulin mediated immune response GO:0016064 ISS     negative regulation of T cell differentiation GO:0045581 IEA     positive regulation of cytokine-mediated signaling pathway GO:0001961 IMP     positive regulation of B cell proliferation GO:0030890 IMP     positive regulation of T cell differentiation GO:0045582 IEA     negative regulation of apoptotic process GO:0043066 IDA     activation of MAPK activity GO:0000187 IEA     intracellular protein transport GO:0006886 ISS     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IMP     positive thymic T cell selection GO:0045059 IEA     negative regulation of peptide secretion GO:0002792 IDA     T cell selection GO:0045058 NAS     cell proliferation GO:0008283 IDA     defense response GO:0006952 IEA     chaperone mediated protein folding requiring cofactor GO:0051085 IEA     protein complex assembly GO:0006461 ISS     signal transduction GO:0007165 IDA     macrophage migration inhibitory factor signaling pathway GO:0035691 IEA     negative thymic T cell selection GO:0045060 IEA     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS     prostaglandin biosynthetic process GO:0001516 IDA     regulation of macrophage activation GO:0043030 NAS     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     positive regulation of neutrophil chemotaxis GO:0090023 ISS     antigen processing and presentation of endogenous antigen GO:0019883 NAS     positive regulation of macrophage cytokine production GO:0060907 ISS     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 ISS     positive regulation of dendritic cell antigen processing and presentation GO:0002606 IEA     positive regulation of fibroblast proliferation GO:0048146 IMP     negative regulation of mature B cell apoptotic process GO:0002906 IEA Subcellular Localization     extracellular exosome GO:0070062 IDA     cell surface GO:0009986 IDA     integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 TAS     MHC class II protein complex GO:0042613 ISS     lysosomal membrane GO:0005765 TAS     vacuole GO:0005773 IDA     multivesicular body GO:0005771 IEA     ER to Golgi transport vesicle membrane GO:0012507 TAS     trans-Golgi network membrane GO:0032588 TAS     intracellular GO:0005622 TAS     endocytic vesicle membrane GO:0030666 TAS     external side of plasma membrane GO:0009897 IEA     lysosomal lumen GO:0043202 TAS     Golgi membrane GO:0000139 TAS     macrophage migration inhibitory factor receptor complex GO:0035692 IDA     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     transport vesicle membrane GO:0030658 TAS     plasma membrane GO:0005886 TAS     integral component of membrane GO:0016021 IDA     NOS2-CD74 complex GO:0035693 IEA     membrane GO:0016020 IDA