Gene description for CD74
Gene name	CD74 molecule, major histocompatibility complex, class II invariant chain
Gene symbol	CD74
Other names/aliases	DHLAG HLADG II Ia-GAMMA
Species	Homo sapiens
Database cross references - CD74
ExoCarta	ExoCarta_972
Vesiclepedia	VP_972
Entrez Gene	972
HGNC	1697
MIM	142790
UniProt	P04233
CD74 identified in exosomes derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Thymus	23844026

Gene ontology annotations for CD74

Molecular Function     amyloid-beta binding GO:0001540 IPI     cytokine receptor activity GO:0004896 IBA     cytokine receptor activity GO:0004896 IDA     protein binding GO:0005515 IPI     cytokine binding GO:0019955 IPI     MHC class II protein complex binding GO:0023026 IDA     macrophage migration inhibitory factor binding GO:0035718 IBA     macrophage migration inhibitory factor binding GO:0035718 IPI     MHC class II protein binding GO:0042289 IBA     MHC class II protein binding GO:0042289 ISS     MHC class II protein binding GO:0042289 NAS     CD4 receptor binding GO:0042609 IPI     MHC class II protein binding, via antigen binding groove GO:0042658 IDA     identical protein binding GO:0042802 TAS     protein folding chaperone GO:0044183 IDA     nitric-oxide synthase binding GO:0050998 IEA Biological Process     prostaglandin biosynthetic process GO:0001516 IDA     positive regulation of protein phosphorylation GO:0001934 IDA     positive regulation of cytokine-mediated signaling pathway GO:0001961 IBA     positive regulation of cytokine-mediated signaling pathway GO:0001961 IMP     T cell activation involved in immune response GO:0002286 IBA     positive regulation of dendritic cell antigen processing and presentation GO:0002606 IEA     negative regulation of peptide secretion GO:0002792 IDA     positive regulation of type 2 immune response GO:0002830 IBA     negative regulation of mature B cell apoptotic process GO:0002906 IEA     intracellular protein transport GO:0006886 ISS     positive regulation of gene expression GO:0010628 IMP     immunoglobulin mediated immune response GO:0016064 ISS     antigen processing and presentation GO:0019882 IBA     antigen processing and presentation of endogenous antigen GO:0019883 NAS     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IEA     negative regulation of cell migration GO:0030336 IMP     positive regulation of B cell proliferation GO:0030890 IMP     positive regulation of prostaglandin biosynthetic process GO:0031394 IMP     positive regulation of chemokine production GO:0032722 IMP     positive regulation of interleukin-6 production GO:0032755 IMP     positive regulation of interleukin-8 production GO:0032757 IMP     positive regulation of kinase activity GO:0033674 IDA     response to type II interferon GO:0034341 IDA     macrophage migration inhibitory factor signaling pathway GO:0035691 IEA     regulation of macrophage activation GO:0043030 NAS     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA     positive regulation of MAPK cascade GO:0043410 IDA     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IBA     negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IDA     T cell selection GO:0045058 NAS     positive thymic T cell selection GO:0045059 IEA     negative thymic T cell selection GO:0045060 IEA     negative regulation of T cell differentiation GO:0045581 IEA     positive regulation of T cell differentiation GO:0045582 IEA     positive regulation of monocyte differentiation GO:0045657 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     negative regulation of viral entry into host cell GO:0046597 IDA     positive regulation of viral entry into host cell GO:0046598 IDA     positive regulation of fibroblast proliferation GO:0048146 IMP     protein stabilization GO:0050821 ISS     chaperone cofactor-dependent protein refolding GO:0051085 IEA     positive regulation of macrophage cytokine production GO:0060907 IBA     positive regulation of macrophage cytokine production GO:0060907 ISS     protein-containing complex assembly GO:0065003 ISS     protein trimerization GO:0070206 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IBA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     positive regulation of neutrophil chemotaxis GO:0090023 ISS     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IBA     negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IMP     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 ISS     positive regulation of macrophage migration inhibitory factor signaling pathway GO:2000448 IMP Subcellular Localization     Golgi membrane GO:0000139 TAS     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     lysosome GO:0005764 ISS     lysosomal membrane GO:0005765 TAS     late endosome GO:0005770 ISS     multivesicular body GO:0005771 IEA     vacuole GO:0005773 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IEA     cell surface GO:0009986 IBA     cell surface GO:0009986 IDA     ER to Golgi transport vesicle membrane GO:0012507 TAS     membrane GO:0016020 HDA     membrane GO:0016020 IDA     transport vesicle membrane GO:0030658 TAS     endocytic vesicle membrane GO:0030666 TAS     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     trans-Golgi network membrane GO:0032588 TAS     protein-containing complex GO:0032991 IDA     macrophage migration inhibitory factor receptor complex GO:0035692 IDA     NOS2-CD74 complex GO:0035693 IEA     MHC class II protein complex GO:0042613 ISS     lysosomal lumen GO:0043202 TAS     extracellular exosome GO:0070062 HDA     lumenal side of endoplasmic reticulum membrane GO:0098553 TAS