Gene description for EIF2B4
Gene name eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Gene symbol EIF2B4
Other names/aliases EIF-2B
Species Homo sapiens
 Database cross references - EIF2B4
ExoCarta ExoCarta_8890
Entrez Gene 8890
HGNC 3260
MIM 606687
UniProt Q9UI10  
 EIF2B4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for EIF2B4
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IMP
    protein binding GO:0005515 IPI
    S-methyl-5-thioribose-1-phosphate isomerase activity GO:0046523 IBA
    translation initiation factor activity GO:0003743 IDA
    translation initiation factor binding GO:0031369 ISS
Biological Process
    oligodendrocyte development GO:0014003 IMP
    myelination GO:0042552 IMP
    translation GO:0006412 TAS
    positive regulation of GTPase activity GO:0043547 IMP
    regulation of translation GO:0006417 NAS
    negative regulation of translational initiation GO:0045947 IBA
    L-methionine biosynthetic process from methylthioadenosine GO:0019509 IBA
    response to peptide hormone GO:0043434 ISS
    response to heat GO:0009408 TAS
    ovarian follicle development GO:0001541 IMP
    gene expression GO:0010467 TAS
    cellular protein metabolic process GO:0044267 TAS
    response to glucose GO:0009749 ISS
    negative regulation of translational initiation in response to stress GO:0032057 ISS
    cellular response to stimulus GO:0051716 IDA
    translational initiation GO:0006413 TAS
Subcellular Localization
    eukaryotic translation initiation factor 2B complex GO:0005851 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified EIF2B4 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EIF2B4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF2S1 1965
Invivo Homo sapiens
2 EIF2B4 8890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 EIF2B3 8891
Affinity Capture-MS Homo sapiens
4 EIF2S2 8894
Affinity Capture-MS Homo sapiens
5 EIF2B2 8892
Affinity Capture-MS Homo sapiens
6 EIF2B5 8893
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which EIF2B4 is involved
Recycling of eIF2:GDP TAS Reactome

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