Gene description for EIF2B1
Gene name eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Gene symbol EIF2B1
Other names/aliases EIF2B
Species Homo sapiens
 Database cross references - EIF2B1
ExoCarta ExoCarta_1967
Entrez Gene 1967
HGNC 3257
MIM 606686
UniProt Q14232  
 EIF2B1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for EIF2B1
Molecular Function
    protein binding GO:0005515 IPI
    GDP binding GO:0019003 IEA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    S-methyl-5-thioribose-1-phosphate isomerase activity GO:0046523 IBA
    translation initiation factor activity GO:0003743 IDA
    enzyme regulator activity GO:0030234 IEA
    GTP binding GO:0005525 IEA
Biological Process
    response to heat GO:0009408 TAS
    positive regulation of GTPase activity GO:0043547 IDA
    regulation of translational initiation GO:0006446 IBA
    translation GO:0006412 TAS
    negative regulation of translational initiation in response to stress GO:0032057 IEA
    cellular response to stimulus GO:0051716 IDA
    oligodendrocyte development GO:0014003 IMP
    response to glucose GO:0009749 ISS
    L-methionine biosynthetic process from methylthioadenosine GO:0019509 IBA
    gene expression GO:0010467 TAS
    response to peptide hormone GO:0043434 ISS
    translational initiation GO:0006413 TAS
    cellular protein metabolic process GO:0044267 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    eukaryotic translation initiation factor 2B complex GO:0005851 IDA
 Experiment description of studies that identified EIF2B1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EIF2B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRA2C  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
3 EIF2S1 1965
Reconstituted Complex Homo sapiens
4 ADRB2  
Reconstituted Complex Homo sapiens
5 ARF4L  
Two-hybrid Homo sapiens
6 HNRNPL 3191
Affinity Capture-MS Homo sapiens
7 MRPL4  
Two-hybrid Homo sapiens
8 ADRA2B  
Reconstituted Complex Homo sapiens
9 DCD 117159
Affinity Capture-MS Homo sapiens
10 EIF2B3 8891
Affinity Capture-MS Homo sapiens
11 EIF2B5 8893
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
12 PDIA4 9601
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EIF2B1 is involved
Recycling of eIF2:GDP TAS Reactome

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