Gene description for MTAP
Gene name methylthioadenosine phosphorylase
Gene symbol MTAP
Other names/aliases BDMF
DMSFH
DMSMFH
HEL-249
LGMBF
MSAP
c86fus
Species Homo sapiens
 Database cross references - MTAP
ExoCarta ExoCarta_4507
Entrez Gene 4507
HGNC 7413
MIM 156540
UniProt Q13126  
 MTAP identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for MTAP
Molecular Function
    phosphorylase activity GO:0004645 IEA
    S-methyl-5-thioadenosine phosphorylase activity GO:0017061 TAS
    protein binding GO:0005515 IPI
Biological Process
    L-methionine biosynthetic process from methylthioadenosine GO:0019509 TAS
    sulfur amino acid metabolic process GO:0000096 TAS
    small molecule metabolic process GO:0044281 TAS
    nicotinamide riboside catabolic process GO:0006738 IDA
    polyamine metabolic process GO:0006595 TAS
    purine-containing compound salvage GO:0043101 IBA
    purine ribonucleoside salvage GO:0006166 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    nucleobase-containing compound metabolic process GO:0006139 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified MTAP in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MTAP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MYLIP  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MTAP is involved
PathwayEvidenceSource
Methionine salvage pathway TAS Reactome





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