Gene description for CLCN5
Gene name chloride channel, voltage-sensitive 5
Gene symbol CLCN5
Other names/aliases CLC5
CLCK2
ClC-5
DENTS
NPHL1
NPHL2
XLRH
XRN
hCIC-K2
Species Homo sapiens
 Database cross references - CLCN5
ExoCarta ExoCarta_1184
Entrez Gene 1184
HGNC 2023
MIM 300008
UniProt P51795  
 CLCN5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CLCN5
Molecular Function
    chloride channel activity GO:0005254 TAS
    voltage-gated chloride channel activity GO:0005247 IEA
    ATP binding GO:0005524 IEA
    antiporter activity GO:0015297 IEA
Biological Process
    transmembrane transport GO:0055085 TAS
    regulation of anion transmembrane transport GO:1903959 IEA
    chloride transmembrane transport GO:1902476 TAS
    ion transmembrane transport GO:0034220 TAS
    excretion GO:0007588 TAS
    transport GO:0006810 TAS
    endocytosis GO:0006897 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    apical part of cell GO:0045177 IDA
    membrane GO:0016020 IDA
    integral component of plasma membrane GO:0005887 TAS
    Golgi membrane GO:0000139 IEA
    endosome membrane GO:0010008 TAS
 Experiment description of studies that identified CLCN5 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLCN5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLCN5 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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