Gene description for SNX12
Gene name sorting nexin 12
Gene symbol SNX12
Other names/aliases -
Species Homo sapiens
 Database cross references - SNX12
ExoCarta ExoCarta_29934
Entrez Gene 29934
HGNC 14976
MIM 300883
UniProt Q9UMY4  
 SNX12 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SNX12
Molecular Function
    enzyme binding GO:0019899 IPI
    phosphatidylinositol binding GO:0035091 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of protein processing GO:0010955 IDA
    endocytosis GO:0006897 IBA
    protein transport GO:0015031 IEA
    negative regulation of protein catabolic process GO:0042177 IDA
    vesicle organization GO:0016050 IBA
    negative regulation of early endosome to late endosome transport GO:2000642 IDA
    negative regulation of protein transport GO:0051224 IDA
    negative regulation of gene expression GO:0010629 IMP
    regulation of endocytosis GO:0030100 IMP
Subcellular Localization
    extrinsic component of membrane GO:0019898 IBA
    early endosome GO:0005769 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SNX12 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SNX12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SNX12 is involved
No pathways found





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