Gene description for IGBP1
Gene name immunoglobulin (CD79A) binding protein 1
Gene symbol IGBP1
Other names/aliases ALPHA-4
IBP1
Species Homo sapiens
 Database cross references - IGBP1
ExoCarta ExoCarta_3476
Vesiclepedia VP_3476
Entrez Gene 3476
HGNC 5461
MIM 300139
UniProt P78318  
 IGBP1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for IGBP1
Molecular Function
    protein phosphatase type 2A regulator activity GO:0008601 IDA
    protein binding GO:0005515 IPI
    mitogen-activated protein kinase kinase binding GO:0031434 IEA
    protein phosphatase 2A binding GO:0051721 IBA
    protein domain specific binding GO:0019904 IEA
Biological Process
    positive regulation of dephosphorylation GO:0035306 IEA
    negative regulation of protein dephosphorylation GO:0035308 IEA
    regulation of microtubule-based movement GO:0060632 IMP
    B cell activation GO:0042113 IEA
    signal transduction GO:0007165 NAS
    regulation of protein phosphatase type 2A activity GO:0034047 IDA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IMP
    response to tumor necrosis factor GO:0034612 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    response to interleukin-1 GO:0070555 IMP
    negative regulation of stress-activated MAPK cascade GO:0032873 IMP
    negative regulation of apoptotic signaling pathway GO:2001234 IEA
Subcellular Localization
    cytoplasm GO:0005737 NAS
    microtubule GO:0005874 IEA
    cytosol GO:0005829 IBA
 Experiment description of studies that identified IGBP1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IGBP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 PPP2CB 5516
Affinity Capture-MS Homo sapiens
3 CCT6A 908
Affinity Capture-MS Homo sapiens
4 CCT5 22948
Affinity Capture-MS Homo sapiens
5 PPP6C 5537
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 CCT3 7203
Affinity Capture-MS Homo sapiens
7 TCP1 6950
Affinity Capture-MS Homo sapiens
8 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
9 CCT8 10694
Affinity Capture-MS Homo sapiens
10 MID2 11043
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
11 CCT7 10574
Affinity Capture-MS Homo sapiens
12 CCT4 10575
Affinity Capture-MS Homo sapiens
13 MID1 4281
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 CCT2 10576
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGBP1 is involved
No pathways found





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