Gene description for UBR5
Gene name ubiquitin protein ligase E3 component n-recognin 5
Gene symbol UBR5
Other names/aliases DD5
EDD
EDD1
HYD
Species Homo sapiens
 Database cross references - UBR5
ExoCarta ExoCarta_51366
Vesiclepedia VP_51366
Entrez Gene 51366
HGNC 16806
MIM 608413
UniProt O95071  
 UBR5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UBR5
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 TAS
    ligase activity GO:0016874 IEA
    zinc ion binding GO:0008270 IEA
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
    ubiquitin binding GO:0043130 IEA
    ubiquitin-ubiquitin ligase activity GO:0034450 IDA
Biological Process
    positive regulation of catenin import into nucleus GO:0035413 IMP
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
    progesterone receptor signaling pathway GO:0050847 IDA
    cellular response to DNA damage stimulus GO:0006974 IMP
    positive regulation of protein import into nucleus, translocation GO:0033160 IMP
    DNA repair GO:0006281 IEA
    protein polyubiquitination GO:0000209 IDA
    negative regulation of histone H2A K63-linked ubiquitination GO:1901315 IMP
    positive regulation of canonical Wnt signaling pathway GO:0090263 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
    negative regulation of double-strand break repair GO:2000780 IMP
    cell proliferation GO:0008283 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified UBR5 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UBR5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
2 MCRS1  
Affinity Capture-MS Homo sapiens
3 CIB1 10519
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 MAPK3 5595
Affinity Capture-Western Homo sapiens
5 MAGED1 9500
Affinity Capture-MS Homo sapiens
6 PGR  
Reconstituted Complex Homo sapiens
7 TOPBP1 11073
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
8 KPNA1 3836
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UBR5 is involved
No pathways found





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