Gene description for UBE2D1
Gene name ubiquitin-conjugating enzyme E2D 1
Gene symbol UBE2D1
Other names/aliases E2(17)KB1
SFT
UBC4/5
UBCH5
UBCH5A
Species Homo sapiens
 Database cross references - UBE2D1
ExoCarta ExoCarta_7321
Vesiclepedia VP_7321
Entrez Gene 7321
HGNC 12474
MIM 602961
UniProt P51668  
 UBE2D1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UBE2D1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin conjugating enzyme activity GO:0061631 IBA
    ubiquitin conjugating enzyme activity GO:0061631 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    protein polyubiquitination GO:0000209 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    negative regulation of BMP signaling pathway GO:0030514 TAS
    positive regulation of protein ubiquitination GO:0031398 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    protein K48-linked ubiquitination GO:0070936 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
    positive regulation of protein polyubiquitination GO:1902916 IEA
    negative regulation of TORC1 signaling GO:1904262 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified UBE2D1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UBE2D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 KLHL9 55958
Reconstituted Complex Homo sapiens
3 RING1 6015
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
4 Stat5a  
Biochemical Activity Mus musculus
5 TNFAIP3 7128
Reconstituted Complex Homo sapiens
6 CRBN  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
7 STAM2 10254
Biochemical Activity Homo sapiens
8 UTRN 7402
Co-fractionation Homo sapiens
9 XIAP  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
10 RNF122  
Reconstituted Complex Homo sapiens
11 MCM2 4171
Affinity Capture-MS Homo sapiens
12 SIAH2 6478
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
13 RNF167 26001
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 WWP1 11059
Reconstituted Complex Homo sapiens
15 MARCH7  
Two-hybrid Homo sapiens
16 GADD45A  
Two-hybrid Homo sapiens
17 TRIM35 23087
Two-hybrid Homo sapiens
18 BRMS1 25855
Reconstituted Complex Homo sapiens
19 RNF25 64320
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
20 MARCH2  
Reconstituted Complex Homo sapiens
21 SH3RF1  
Reconstituted Complex Homo sapiens
22 UBA1 7317
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
23 BRCA1 672
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
24 EPS15 2060
Biochemical Activity Homo sapiens
25 UBE3A 7337
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
26 USP9X 8239
Co-fractionation Homo sapiens
Co-purification Homo sapiens
27 UBC 7316
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
28 CHFR  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 SH3BGRL2  
Co-fractionation Homo sapiens
30 VHL  
Reconstituted Complex Homo sapiens
31 TRIM55  
Two-hybrid Homo sapiens
32 MID1 4281
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 Rag1  
Reconstituted Complex Mus musculus
34 RFFL 117584
Reconstituted Complex Homo sapiens
35 RCHY1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
36 Trim21  
Reconstituted Complex Rattus norvegicus
37 IGBP1 3476
Co-fractionation Homo sapiens
38 TRIM28 10155
Reconstituted Complex Homo sapiens
39 DTX3  
Two-hybrid Homo sapiens
40 RNF5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 PELI1 57162
Reconstituted Complex Homo sapiens
42 CADPS2  
Two-hybrid Homo sapiens
43 TRAIP  
Reconstituted Complex Homo sapiens
44 POLL  
Biochemical Activity Homo sapiens
45 TBL1XR1 79718
Affinity Capture-Western Homo sapiens
46 MYLIP  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
47 RNF8  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
48 UBE2B 7320
Co-fractionation Homo sapiens
49 FZR1  
Reconstituted Complex Homo sapiens
50 TRIM50  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
51 BRCC3 79184
Reconstituted Complex Homo sapiens
52 UBOX5  
Two-hybrid Homo sapiens
53 TMEM129  
Reconstituted Complex Homo sapiens
54 ASB9  
Reconstituted Complex Homo sapiens
55 MARCH5  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
56 Zswim2  
Affinity Capture-Western Mus musculus
57 TOM1 10043
Reconstituted Complex Homo sapiens
58 ANAPC11  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
59 YAP1 10413
Co-fractionation Homo sapiens
60 MKRN3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 MID2 11043
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 LRSAM1 90678
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
63 ASB4  
Reconstituted Complex Homo sapiens
64 TRIM26 7726
Two-hybrid Homo sapiens
65 APEX1 328
Affinity Capture-RNA Homo sapiens
66 BIRC3 330
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
67 POLM  
Biochemical Activity Homo sapiens
68 RNF126  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
69 BTRC 8945
Affinity Capture-Western Homo sapiens
70 ARIH2 10425
Two-hybrid Homo sapiens
71 CDC5L 988
Affinity Capture-MS Homo sapiens
72 FAF2 23197
Reconstituted Complex Homo sapiens
73 NEDD4 4734
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
74 ATP6V1F 9296
Co-fractionation Homo sapiens
75 RNF207  
Reconstituted Complex Homo sapiens
76 BFAR  
Two-hybrid Homo sapiens
77 GSK3B 2932
Two-hybrid Homo sapiens
78 RNF11 26994
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 RNF115  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 TRIM8  
Two-hybrid Homo sapiens
81 WDR1 9948
Co-fractionation Homo sapiens
82 TRAF4 9618
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
83 UNK  
Co-fractionation Homo sapiens
84 RABGEF1 27342
Reconstituted Complex Homo sapiens
85 TRIM24  
Reconstituted Complex Homo sapiens
86 ANXA7 310
Two-hybrid Homo sapiens
87 RNF6  
Reconstituted Complex Homo sapiens
88 RNF165  
Two-hybrid Homo sapiens
89 MIB1 57534
Two-hybrid Homo sapiens
90 UBE4B 10277
Co-fractionation Homo sapiens
91 SHPRH  
Reconstituted Complex Homo sapiens
92 RNF4 6047
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 TRIM7  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
94 RBX1 9978
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-RNA Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
95 CDKN1A  
Two-hybrid Homo sapiens
96 NEURL1  
Reconstituted Complex Homo sapiens
97 NR1H2  
Two-hybrid Homo sapiens
98 AMFR 267
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 DTX1  
Two-hybrid Homo sapiens
100 BRE 9577
Reconstituted Complex Homo sapiens
101 THRSP  
Affinity Capture-MS Homo sapiens
102 NBN 4683
Reconstituted Complex Homo sapiens
103 CBL 867
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
104 CNOT4 4850
Reconstituted Complex Homo sapiens
105 RNF146  
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
106 ZNRF2 223082
Two-hybrid Homo sapiens
107 UBASH3B 84959
Biochemical Activity Homo sapiens
108 RAG1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
109 EP300 2033
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
110 MKRN2 23609
Two-hybrid Homo sapiens
111 PMAIP1  
Reconstituted Complex Homo sapiens
112 BARD1 580
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
113 TRIM21 6737
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
114 RNF166  
Two-hybrid Homo sapiens
115 RNF123 63891
Affinity Capture-MS Homo sapiens
116 HERC2 8924
Reconstituted Complex Homo sapiens
117 DTX2 113878
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
118 RLIM 51132
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
119 F12  
Reconstituted Complex Homo sapiens
120 TRIM32 22954
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
121 KLHL2 11275
Reconstituted Complex Homo sapiens
122 TRIM11  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
123 MARCH8  
Reconstituted Complex Homo sapiens
124 RNF13 11342
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
125 UBE2D3 7323
Affinity Capture-MS Homo sapiens
126 HECTD1 25831
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
127 CUL2 8453
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 RNF125  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
129 TRIM17  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
130 SIVA1  
Reconstituted Complex Homo sapiens
131 ITCH 83737
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
132 TNNT1  
Two-hybrid Homo sapiens
133 TRIM63  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
134 HIF1A 3091
Biochemical Activity Homo sapiens
135 TTLL12 23170
Co-fractionation Homo sapiens
136 AREL1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
137 Rnf4  
Co-crystal Structure Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Reconstituted Complex Rattus norvegicus
138 ZPR1 8882
Co-fractionation Homo sapiens
139 RNF168  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
140 TRIM2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
141 BIRC2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
142 DTL  
Reconstituted Complex Homo sapiens
143 CYP3A4  
Affinity Capture-MS Homo sapiens
144 RNF34  
Reconstituted Complex Homo sapiens
145 CDK7 1022
Reconstituted Complex Homo sapiens
146 CAND2 23066
Co-purification Homo sapiens
147 NHLRC1  
Reconstituted Complex Homo sapiens
148 AHCYL1 10768
Co-fractionation Homo sapiens
149 RNF181  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
150 MARCH1  
Reconstituted Complex Homo sapiens
151 RELA 5970
Biochemical Activity Homo sapiens
152 UBXN7 26043
Co-fractionation Homo sapiens
153 TRIM10  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
154 RNF128  
Reconstituted Complex Homo sapiens
155 CRYAB 1410
Reconstituted Complex Homo sapiens
156 CTNNB1 1499
Reconstituted Complex Homo sapiens
157 NFKBIA  
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
158 ANXA1 301
Two-hybrid Homo sapiens
159 RNF130  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
160 SSSCA1 10534
Co-fractionation Homo sapiens
161 RNF150  
Two-hybrid Homo sapiens
162 TRAF6 7189
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
163 CUL3 8452
Reconstituted Complex Homo sapiens
164 PTEN 5728
Synthetic Growth Defect Homo sapiens
165 UHRF2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
166 Rbx1  
Reconstituted Complex Mus musculus
167 HSD17B10 3028
Two-hybrid Homo sapiens
168 MAP3K1 4214
Two-hybrid Homo sapiens
169 MDM4  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
170 ZFYVE19 84936
Co-fractionation Homo sapiens
171 KLHL13 90293
Reconstituted Complex Homo sapiens
172 CAND1 55832
Co-purification Homo sapiens
173 MGRN1 23295
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
174 BIRC6 57448
Reconstituted Complex Homo sapiens
175 TRIM3 10612
Reconstituted Complex Homo sapiens
176 UBR1 197131
Co-purification Homo sapiens
177 FOS 2353
Biochemical Activity Homo sapiens
178 RNF103  
Two-hybrid Homo sapiens
179 KCTD17 79734
Reconstituted Complex Homo sapiens
180 FBXO2 26232
Reconstituted Complex Homo sapiens
181 TRIM27  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
182 TBL1X 6907
Biochemical Activity Homo sapiens
183 TRAF2 7186
Reconstituted Complex Homo sapiens
184 UBTD1 80019
Co-purification Homo sapiens
185 UBL7  
Co-fractionation Homo sapiens
186 DYRK2 8445
Reconstituted Complex Homo sapiens
187 RFWD3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
188 RNF2  
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
189 Nedd4 17999
Reconstituted Complex Mus musculus
190 msl-2  
Reconstituted Complex Drosophila melanogaster
191 RNF114 55905
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
192 RNF26  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
193 RNF185  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
194 TRIM39  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
195 KDM2B 84678
Biochemical Activity Homo sapiens
196 MDM2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
197 NEDD4L 23327
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
198 HUWE1 10075
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
199 UBE2D1 7321
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
200 CBLC  
Reconstituted Complex Homo sapiens
201 STUB1 10273
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
202 DZIP3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
203 TRIM5 85363
Two-hybrid Homo sapiens
204 TRAF7  
Two-hybrid Homo sapiens
205 RNF43  
Two-hybrid Homo sapiens
206 TRIM38 10475
Two-hybrid Homo sapiens
207 BIRC7  
Two-hybrid Homo sapiens
208 MUL1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
209 SPOP  
Reconstituted Complex Homo sapiens
210 UBQLN1 29979
Co-fractionation Homo sapiens
211 SIRT6  
Two-hybrid Homo sapiens
212 WDR4 10785
Co-fractionation Homo sapiens
213 DTX3L 151636
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
214 HECW1  
Reconstituted Complex Homo sapiens
215 USP34 9736
Co-fractionation Homo sapiens
216 RNF14 9604
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
217 URGCP 55665
Affinity Capture-MS Homo sapiens
218 MKNK1  
Two-hybrid Homo sapiens
219 BIRC8  
Two-hybrid Homo sapiens
220 RFWD2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
221 RNF10  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
222 RNF31 55072
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
223 KAT2B  
Reconstituted Complex Homo sapiens
224 KEAP1 9817
Reconstituted Complex Homo sapiens
225 TRIM45  
Two-hybrid Homo sapiens
226 SKP1 6500
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
227 SMURF1 57154
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
228 ZNRF1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
229 UBE4A 9354
Two-hybrid Homo sapiens
230 CREBBP  
Reconstituted Complex Homo sapiens
231 TKT 7086
Co-fractionation Homo sapiens
232 OTUB1 55611
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 TAF1D  
Two-hybrid Homo sapiens
234 RNF111 54778
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
235 DDX58 23586
Biochemical Activity Homo sapiens
236 UBR5 51366
Co-fractionation Homo sapiens
237 TRIM25 7706
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
238 RNF7  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
239 UBE3C 9690
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
240 TRIP12 9320
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
241 FBXL20 84961
Reconstituted Complex Homo sapiens
242 WWP2 11060
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
243 RNF38  
Two-hybrid Homo sapiens
244 TRIM37  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
245 TSC22D1 8848
Two-hybrid Homo sapiens
246 HDAC6 10013
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
247 TRIM23 373
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
248 ZNRF4  
Two-hybrid Homo sapiens
249 TRIM31  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
250 RNF182  
Reconstituted Complex Homo sapiens
251 UFM1 51569
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
252 HERC3 8916
Reconstituted Complex Homo sapiens
253 PSMB7 5695
Co-fractionation Homo sapiens
254 TRIM69 140691
Reconstituted Complex Homo sapiens
255 TOPORS  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
256 MARCH4  
Reconstituted Complex Homo sapiens
257 C7orf25  
Two-hybrid Homo sapiens
258 UHRF1 29128
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
259 HERC5 51191
Reconstituted Complex Homo sapiens
260 SMURF2 64750
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
261 TRIM43  
Two-hybrid Homo sapiens
262 UBA6 55236
Reconstituted Complex Homo sapiens
263 UPP1 7378
Co-fractionation Homo sapiens
264 UBE2D2 7322
Co-fractionation Homo sapiens
265 RBCK1  
Reconstituted Complex Homo sapiens
266 Nedd4l 83814
Reconstituted Complex Mus musculus
267 ASB2  
Reconstituted Complex Homo sapiens
268 ARIH1 25820
Reconstituted Complex Homo sapiens
269 Ubox5  
Two-hybrid Mus musculus
270 PJA2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which UBE2D1 is involved
PathwayEvidenceSource
Aberrant regulation of mitotic cell cycle due to RB1 defects TAS Reactome
Aberrant regulation of mitotic exit in cancer due to RB1 defects TAS Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
Autodegradation of Cdh1 by Cdh1:APC/C TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
CDK-mediated phosphorylation and removal of Cdc6 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to hypoxia TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Death Receptor Signaling TAS Reactome
Deubiquitination TAS Reactome
Disease TAS Reactome
Diseases of mitotic cell cycle TAS Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity TAS Reactome
Downstream TCR signaling TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of APC/C via direct inhibition of the APC/C complex TAS Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components TAS Reactome
Innate Immune System IEA Reactome
Innate Immune System TAS Reactome
M Phase TAS Reactome
Metabolism of proteins TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
Neddylation TAS Reactome
Negative regulators of DDX58/IFIH1 signaling IEA Reactome
Ovarian tumor domain proteases TAS Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TAS Reactome
Peroxisomal protein import TAS Reactome
Phosphorylation of the APC/C TAS Reactome
Post-translational protein modification TAS Reactome
Protein localization TAS Reactome
Protein ubiquitination TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
RNA Polymerase II Transcription TAS Reactome
S Phase TAS Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signaling by BMP TAS Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGFB family members TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis of active ubiquitin: roles of E1 and E2 enzymes TAS Reactome
Synthesis of DNA TAS Reactome
TCR signaling TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TNF signaling TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome





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