Gene description for CDK7
Gene name cyclin-dependent kinase 7
Gene symbol CDK7
Other names/aliases CAK1
CDKN7
HCAK
MO15
STK1
p39MO15
Species Homo sapiens
 Database cross references - CDK7
ExoCarta ExoCarta_1022
Vesiclepedia VP_1022
Entrez Gene 1022
HGNC 1778
MIM 601955
UniProt P50613  
 CDK7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CDK7
Molecular Function
    ATP binding GO:0005524 IEA
    androgen receptor binding GO:0050681 NAS
    protein binding GO:0005515 IPI
    RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 IDA
    DNA-dependent ATPase activity GO:0008094 IDA
    transcription coactivator activity GO:0003713 NAS
    protein C-terminus binding GO:0008022 IPI
    protein kinase activity GO:0004672 TAS
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA
Biological Process
    transcription-coupled nucleotide-excision repair GO:0006283 TAS
    termination of RNA polymerase I transcription GO:0006363 TAS
    mitotic cell cycle GO:0000278 TAS
    nucleotide-excision repair GO:0006289 TAS
    G1/S transition of mitotic cell cycle GO:0000082 TAS
    nucleotide-excision repair, DNA damage removal GO:0000718 TAS
    transcription elongation from RNA polymerase I promoter GO:0006362 TAS
    cell proliferation GO:0008283 TAS
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    DNA repair GO:0006281 TAS
    positive regulation of transcription, DNA-templated GO:0045893 NAS
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    protein phosphorylation GO:0006468 IEA
    gene expression GO:0010467 TAS
    transcription from RNA polymerase I promoter GO:0006360 TAS
    viral process GO:0016032 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    cell division GO:0051301 IEA
    positive regulation of viral transcription GO:0050434 TAS
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    androgen receptor signaling pathway GO:0030521 NAS
    7-methylguanosine mRNA capping GO:0006370 TAS
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
    negative regulation of gene expression, epigenetic GO:0045814 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    regulation of gene expression, epigenetic GO:0040029 TAS
    transcription initiation from RNA polymerase I promoter GO:0006361 TAS
    cell cycle arrest GO:0007050 TAS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IEA
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
    holo TFIIH complex GO:0005675 IDA
 Experiment description of studies that identified CDK7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CDK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 THRA  
Affinity Capture-MS Homo sapiens
2 MCM7 4176
Invivo Homo sapiens
3 CUX1 1523
Reconstituted Complex Homo sapiens
4 ERCC3  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
5 SURB7  
Affinity Capture-Western Homo sapiens
6 AR 367
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 RARA 5914
Affinity Capture-MS Homo sapiens
8 HDAC2 3066
Affinity Capture-Western Homo sapiens
9 CCNH  
Invivo Homo sapiens
10 MNAT1  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
11 GTF2H5  
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
12 ESR1  
Biochemical Activity Homo sapiens
13 GTF2H1 2965
Affinity Capture-Western Homo sapiens
14 MTA1 9112
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CDK7 is involved
PathwayEvidenceSource
Cyclin A/B1 associated events during G2/M transition TAS Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
Dual incision reaction in GG-NER TAS Reactome
Dual incision reaction in TC-NER TAS Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of incision complex in GG-NER TAS Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Formation of transcription-coupled NER (TC-NER) repair complex TAS Reactome
HIV Transcription Initiation IEA Reactome
mRNA Capping TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
RNA Pol II CTD phosphorylation and interaction with CE TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE IEA Reactome
RNA Polymerase I Chain Elongation TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Transcription Initiation TAS Reactome
RNA Polymerase I Transcription Termination TAS Reactome
RNA Polymerase II HIV Promoter Escape IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA Polymerase II Promoter Escape TAS Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
RNA Polymerase II Transcription Initiation TAS Reactome
RNA Polymerase II Transcription Initiation And Promoter Clearance TAS Reactome
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAS Reactome
Tat-mediated elongation of the HIV-1 transcript TAS Reactome
Transcription of the HIV genome IEA Reactome





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