Gene description for E2F1
Gene name	E2F transcription factor 1
Gene symbol	E2F1
Other names/aliases	E2F-1 RBAP1 RBBP3 RBP3
Species	Homo sapiens
Database cross references - E2F1
ExoCarta	ExoCarta_1869
Vesiclepedia	VP_1869
Entrez Gene	1869
HGNC	3113
MIM	189971
UniProt	Q01094
E2F1 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for E2F1

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IMP     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     cis-regulatory region sequence-specific DNA binding GO:0000987 IDA     DNA-binding transcription activator activity GO:0001216 IDA     DNA binding GO:0003677 IDA     DNA binding GO:0003677 IMP     DNA-binding transcription factor activity GO:0003700 IDA     DNA-binding transcription factor activity GO:0003700 TAS     protein binding GO:0005515 IPI     sequence-specific DNA binding GO:0043565 IDA     sequence-specific DNA binding GO:0043565 ISS     protein dimerization activity GO:0046983 IEA     molecular adaptor activity GO:0060090 EXP     DNA-binding transcription factor binding GO:0140297 IPI     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     DNA damage checkpoint signaling GO:0000077 IMP     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     DNA-templated transcription GO:0006351 ISS     regulation of DNA-templated transcription GO:0006355 IDA     regulation of transcription by RNA polymerase II GO:0006357 IBA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP     positive regulation of gene expression GO:0010628 IDA     forebrain development GO:0030900 IEA     response to lipopolysaccharide GO:0032496 IEA     positive regulation of apoptotic process GO:0043065 IDA     anoikis GO:0043276 IEA     negative regulation of DNA binding GO:0043392 IDA     negative regulation of fat cell differentiation GO:0045599 ISS     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of fibroblast proliferation GO:0048146 IMP     mRNA stabilization GO:0048255 IDA     negative regulation of fat cell proliferation GO:0070345 ISS     cellular response to xenobiotic stimulus GO:0071466 IEA     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA     lens fiber cell apoptotic process GO:1990086 IEA     regulation of G1/S transition of mitotic cell cycle GO:2000045 IMP Subcellular Localization     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     nucleus GO:0005634 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IEA     centrosome GO:0005813 IDA     protein-containing complex GO:0032991 IDA     Rb-E2F complex GO:0035189 IBA     Rb-E2F complex GO:0035189 IDA     Rb-E2F complex GO:0035189 IPI     RNA polymerase II transcription regulator complex GO:0090575 IPI