Gene description for NDN
Gene name necdin, melanoma antigen (MAGE) family member
Gene symbol NDN
Other names/aliases HsT16328
PWCR
Species Homo sapiens
 Database cross references - NDN
ExoCarta ExoCarta_4692
Vesiclepedia VP_4692
Entrez Gene 4692
HGNC 7675
MIM 602117
UniProt Q99608  
 NDN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NDN
Molecular Function
    gamma-tubulin binding GO:0043015 IEA
    DNA binding GO:0003677 IEA
Biological Process
    regulation of transcription, DNA-templated GO:0006355 IEA
    axonal fasciculation GO:0007413 IEA
    axon extension GO:0048675 IEA
    nervous system development GO:0007399 TAS
    neuron migration GO:0001764 IEA
    multicellular organismal homeostasis GO:0048871 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 IEA
    sensory perception of pain GO:0019233 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    central nervous system development GO:0007417 IEA
    respiratory system process GO:0003016 IEA
    transcription, DNA-templated GO:0006351 IEA
    glial cell migration GO:0008347 IEA
    regulation of growth GO:0040008 IEA
    genetic imprinting GO:0071514 IEA
    post-embryonic development GO:0009791 IEA
Subcellular Localization
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IEA
    perikaryon GO:0043204 IEA
    nucleus GO:0005634 IEA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified NDN in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 E2F4  
Invivo Homo sapiens
Invitro Homo sapiens
2 NUBP1 4682
Two-hybrid Homo sapiens
3 NUCB2 4925
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 E2F1 1869
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 RPS11 6205
Affinity Capture-MS Homo sapiens
6 HNRNPU 3192
Invitro Homo sapiens
7 PJA1  
Invitro Homo sapiens
8 ARSE 415
Two-hybrid Homo sapiens
9 TMEM33 55161
Affinity Capture-MS Homo sapiens
10 DHCR7 1717
Affinity Capture-MS Homo sapiens
11 NGFR 4804
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 NDN 4692
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 AUP1 550
Affinity Capture-MS Homo sapiens
14 TP53 7157
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
15 IL1A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
16 CERS2 29956
Affinity Capture-MS Homo sapiens
17 SEC61A1 29927
Affinity Capture-MS Homo sapiens
18 SRPRB 58477
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NDN is involved
No pathways found





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