Gene description for DHCR7
Gene name 7-dehydrocholesterol reductase
Gene symbol DHCR7
Other names/aliases SLOS
Species Homo sapiens
 Database cross references - DHCR7
ExoCarta ExoCarta_1717
Entrez Gene 1717
HGNC 2860
MIM 602858
UniProt Q9UBM7  
 DHCR7 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for DHCR7
Molecular Function
    7-dehydrocholesterol reductase activity GO:0047598 IDA
Biological Process
    multicellular organism growth GO:0035264 IEA
    post-embryonic development GO:0009791 IEA
    oxidation-reduction process GO:0055114 IEA
    small molecule metabolic process GO:0044281 TAS
    regulation of cholesterol biosynthetic process GO:0045540 IEA
    regulation of cell proliferation GO:0042127 IEA
    lung development GO:0030324 IEA
    cell differentiation GO:0030154 IEA
    cholesterol biosynthetic process GO:0006695 TAS
    blood vessel development GO:0001568 IEA
Subcellular Localization
    nuclear outer membrane GO:0005640 IDA
    endoplasmic reticulum GO:0005783 IDA
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified DHCR7 in exosomes
1
Experiment ID 79
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for DHCR7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOR1A 1861
Affinity Capture-MS Homo sapiens
2 ACP6  
Affinity Capture-MS Homo sapiens
3 FADS1  
Affinity Capture-MS Homo sapiens
4 NDN  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DHCR7 is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) TAS Reactome
Cholesterol biosynthesis TAS Reactome





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