Gene description for TOMM40
Gene name translocase of outer mitochondrial membrane 40 homolog (yeast)
Gene symbol TOMM40
Other names/aliases C19orf1
D19S1177E
PER-EC1
PEREC1
TOM40
Species Homo sapiens
 Database cross references - TOMM40
ExoCarta ExoCarta_10452
Entrez Gene 10452
HGNC 18001
MIM 608061
UniProt O96008  
 TOMM40 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TOMM40
Molecular Function
    porin activity GO:0015288 IEA
    protein transmembrane transporter activity GO:0008320 TAS
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    ion transport GO:0006811 IEA
    protein targeting to mitochondrion GO:0006626 TAS
    protein transmembrane transport GO:0071806 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IMP
    integral component of membrane GO:0016021 IDA
    pore complex GO:0046930 IEA
    mitochondrial outer membrane translocase complex GO:0005742 IDA
    integral component of mitochondrial outer membrane GO:0031307 ISS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified TOMM40 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TOMM40
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TOMM40 is involved
PathwayEvidenceSource
Mitochondrial protein import TAS Reactome





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