Gene description for COX7C
Gene name cytochrome c oxidase subunit VIIc
Gene symbol COX7C
Other names/aliases -
Species Homo sapiens
 Database cross references - COX7C
ExoCarta ExoCarta_1350
Vesiclepedia VP_1350
Entrez Gene 1350
HGNC 2292
MIM 603774
UniProt P15954  
 COX7C identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX7C
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    generation of precursor metabolites and energy GO:0006091 TAS
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IBA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 NAS
    cellular respiration GO:0045333 NAS
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial membrane GO:0031966 IDA
    respiratory chain complex IV GO:0045277 IDA
 Experiment description of studies that identified COX7C in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX7C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 PSMA6 5687
Co-fractionation Homo sapiens
3 COX5A 9377
Co-fractionation Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 TMBIM6 7009
Affinity Capture-MS Homo sapiens
6 NDUFS1 4719
Co-fractionation Homo sapiens
7 NDUFB5 4711
Co-fractionation Homo sapiens
8 UQCRB 7381
Affinity Capture-MS Homo sapiens
9 NDUFS7 374291
Co-fractionation Homo sapiens
10 NDUFA4 4697
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
11 CPT1A 1374
Co-fractionation Homo sapiens
12 TOMM22 56993
Co-fractionation Homo sapiens
13 NDUFB9 4715
Co-fractionation Homo sapiens
14 NDUFS3 4722
Co-fractionation Homo sapiens
15 TFAM 7019
Co-fractionation Homo sapiens
16 COX7A2L 9167
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
17 COA3 28958
Co-fractionation Homo sapiens
18 CIDEB  
Two-hybrid Homo sapiens
19 SURF1  
Proximity Label-MS Homo sapiens
20 ATP5O 539
Co-fractionation Homo sapiens
21 MINOS1  
Co-fractionation Homo sapiens
22 C20orf24  
Co-fractionation Homo sapiens
23 NDUFV1 4723
Co-fractionation Homo sapiens
24 PHB 5245
Co-fractionation Homo sapiens
25 TOMM40 10452
Co-fractionation Homo sapiens
26 ATP5H 10476
Co-fractionation Homo sapiens
27 CALR 811
Co-fractionation Homo sapiens
28 ANKRD34C  
Co-fractionation Homo sapiens
29 COX1 4512
Affinity Capture-MS Homo sapiens
30 UQCRQ 27089
Co-fractionation Homo sapiens
31 NDUFS5 4725
Co-fractionation Homo sapiens
32 MYO18A 399687
Affinity Capture-MS Homo sapiens
33 MTCH2 23788
Co-fractionation Homo sapiens
34 P4HA1 5033
Co-fractionation Homo sapiens
35 NDUFS4 4724
Co-fractionation Homo sapiens
36 MAGEA2  
Two-hybrid Homo sapiens
37 HSP90B1 7184
Co-fractionation Homo sapiens
38 PAM16  
Co-fractionation Homo sapiens
39 CYB5A 1528
Co-fractionation Homo sapiens
40 PMAIP1  
Affinity Capture-MS Homo sapiens
41 VCP 7415
Co-fractionation Homo sapiens
42 CYC1 1537
Co-fractionation Homo sapiens
43 UQCRC1 7384
Co-fractionation Homo sapiens
44 ACTB 60
Co-fractionation Homo sapiens
45 COX7B 1349
Co-fractionation Homo sapiens
46 MYL12A 10627
Co-fractionation Homo sapiens
47 VDAC2 7417
Co-fractionation Homo sapiens
48 NIPSNAP1 8508
Co-fractionation Homo sapiens
49 SEC61B 10952
Co-fractionation Homo sapiens
50 ATP5B 506
Co-fractionation Homo sapiens
51 COX4I1 1327
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
52 C15orf48  
Affinity Capture-MS Homo sapiens
53 SLC25A24 29957
Co-fractionation Homo sapiens
54 COX5B 1329
Affinity Capture-MS Homo sapiens
55 HADHB 3032
Co-fractionation Homo sapiens
56 HADHA 3030
Co-fractionation Homo sapiens
57 VAPB 9217
Co-fractionation Homo sapiens
58 CANX 821
Co-fractionation Homo sapiens
59 NDUFB10 4716
Co-fractionation Homo sapiens
60 NDUFA9 4704
Co-fractionation Homo sapiens
61 UQCRC2 7385
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
62 BCAP31 10134
Co-fractionation Homo sapiens
63 ATP5F1 515
Co-fractionation Homo sapiens
64 COX6A1  
Co-fractionation Homo sapiens
65 COX6B1 1340
Affinity Capture-MS Homo sapiens
66 CORO1C 23603
Co-fractionation Homo sapiens
67 OCIAD1 54940
Co-fractionation Homo sapiens
68 ZNF782  
Co-fractionation Homo sapiens
69 COX6C 1345
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
70 ASPH 444
Co-fractionation Homo sapiens
71 VDAC1 7416
Co-fractionation Homo sapiens
72 COX2 4513
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
73 SCCPDH 51097
Co-fractionation Homo sapiens
74 NDUFS2 4720
Co-fractionation Homo sapiens
75 GBAS 2631
Co-fractionation Homo sapiens
76 IMMT 10989
Co-fractionation Homo sapiens
77 PHB2 11331
Co-fractionation Homo sapiens
78 MAGEA2B  
Two-hybrid Homo sapiens
79 BCKDHA 593
Co-fractionation Homo sapiens
80 PDHA1 5160
Co-fractionation Homo sapiens
81 FKBP9 11328
Co-fractionation Homo sapiens
82 PDHB 5162
Co-fractionation Homo sapiens
83 COX8A  
Co-fractionation Homo sapiens
84 NDUFS8 4728
Co-fractionation Homo sapiens
85 BCL2L13 23786
Co-fractionation Homo sapiens
86 MGST3 4259
Co-fractionation Homo sapiens
87 SLC25A51  
Proximity Label-MS Homo sapiens
88 ATP5C1 509
Co-fractionation Homo sapiens
89 VDAC3 7419
Co-fractionation Homo sapiens
90 TOMM5  
Co-fractionation Homo sapiens
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