Gene description for BCL2L13
Gene name BCL2-like 13 (apoptosis facilitator)
Gene symbol BCL2L13
Other names/aliases BCL-RAMBO
Bcl2-L-13
MIL1
Species Homo sapiens
 Database cross references - BCL2L13
ExoCarta ExoCarta_23786
Entrez Gene 23786
HGNC 17164
UniProt Q9BXK5  
 BCL2L13 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BCL2L13
Molecular Function
    cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 NAS
    protein binding GO:0005515 IPI
Biological Process
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 NAS
    apoptotic process GO:0006915 NAS
Subcellular Localization
    integral component of membrane GO:0016021 IDA
    mitochondrial membrane GO:0031966 IEA
    mitochondrion GO:0005739 NAS
    nucleus GO:0005634 IEA
 Experiment description of studies that identified BCL2L13 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BCL2L13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GABARAPL2 11345
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BCL2L13 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here