Gene description for BET1
Gene name Bet1 golgi vesicular membrane trafficking protein
Gene symbol BET1
Other names/aliases HBET1
Species Homo sapiens
 Database cross references - BET1
ExoCarta ExoCarta_10282
Vesiclepedia VP_10282
Entrez Gene 10282
HGNC 14562
MIM 605456
UniProt O15155  
 BET1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for BET1
Molecular Function
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IMP
    protein transport GO:0015031 IEA
    vesicle fusion with Golgi apparatus GO:0048280 IBA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cis-Golgi network GO:0005801 IDA
    membrane GO:0016020 HDA
    transport vesicle GO:0030133 TAS
    SNARE complex GO:0031201 IBA
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 TAS
 Experiment description of studies that identified BET1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for BET1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SCFD1 23256
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 C5AR1  
Affinity Capture-MS Homo sapiens
5 VTI1B 10490
Affinity Capture-MS Homo sapiens
6 METTL7A 25840
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 NAPA 8775
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FAM9B  
Two-hybrid Homo sapiens
10 ASGR2  
Two-hybrid Homo sapiens
11 NBAS 51594
Affinity Capture-MS Homo sapiens
12 HSD17B11 51170
Proximity Label-MS Homo sapiens
13 GOSR2 9570
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
14 CD79A  
Two-hybrid Homo sapiens
15 STX4 6810
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 BNIP1 662
Affinity Capture-MS Homo sapiens
17 B3GAT1  
Proximity Label-MS Homo sapiens
18 STX1A 6804
Two-hybrid Homo sapiens
19 USO1 8615
Co-purification Homo sapiens
20 RINT1 60561
Affinity Capture-MS Homo sapiens
21 FAM174A 345757
Two-hybrid Homo sapiens
22 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 STX8 9482
Affinity Capture-MS Homo sapiens
24 CUX1 1523
Affinity Capture-MS Homo sapiens
25 STX7 8417
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
26 ADORA2A  
Two-hybrid Homo sapiens
27 SSR1 6745
Proximity Label-MS Homo sapiens
28 STX18 53407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SCFD2 152579
Affinity Capture-MS Homo sapiens
30 C3orf52  
Affinity Capture-MS Homo sapiens
31 TBC1D15 64786
Affinity Capture-MS Homo sapiens
32 STX6 10228
Affinity Capture-MS Homo sapiens
33 BET1 10282
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GPX8 493869
Two-hybrid Homo sapiens
35 ATP13A3 79572
Affinity Capture-MS Homo sapiens
36 SSMEM1  
Two-hybrid Homo sapiens
37 STX12 23673
Co-fractionation Homo sapiens
38 MARCKS 4082
Proximity Label-MS Homo sapiens
39 IFT20 90410
Affinity Capture-MS Homo sapiens
40 VTI1A 143187
Affinity Capture-MS Homo sapiens
41 LYPD5 284348
Two-hybrid Homo sapiens
42 NUP155 9631
Proximity Label-MS Homo sapiens
43 Snap29  
Affinity Capture-MS Mus musculus
44 MANSC1 54682
Affinity Capture-MS Homo sapiens
45 CLDN7 1366
Two-hybrid Homo sapiens
46 TMCO5A  
Two-hybrid Homo sapiens
47 NRSN1  
Affinity Capture-MS Homo sapiens
48 EMD 2010
Proximity Label-MS Homo sapiens
49 REEP4  
Two-hybrid Homo sapiens
50 JAGN1 84522
Two-hybrid Homo sapiens
51 ACIN1 22985
Co-fractionation Homo sapiens
52 ANKS6 203286
Two-hybrid Homo sapiens
53 CHRNB2  
Affinity Capture-MS Homo sapiens
54 GORASP2 26003
Affinity Capture-MS Homo sapiens
55 OPA1 4976
Affinity Capture-MS Homo sapiens
56 IL20RA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 KCNJ6  
Two-hybrid Homo sapiens
58 RPN1 6184
Proximity Label-MS Homo sapiens
59 STX5 6811
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
60 ELOVL5 60481
Proximity Label-MS Homo sapiens
61 MFF 56947
Two-hybrid Homo sapiens
62 SEC61B 10952
Proximity Label-MS Homo sapiens
63 COX4I1 1327
Affinity Capture-MS Homo sapiens
64 TMEM35  
Two-hybrid Homo sapiens
65 CRELD1 78987
Affinity Capture-MS Homo sapiens
66 TMEM52B 120939
Two-hybrid Homo sapiens
67 TTYH1  
Affinity Capture-MS Homo sapiens
68 VAMP8 8673
Affinity Capture-MS Homo sapiens
69 LRRC59 55379
Proximity Label-MS Homo sapiens
70 CRB3 92359
Two-hybrid Homo sapiens
71 ERGIC3 51614
Two-hybrid Homo sapiens
72 HSD3B7 80270
Proximity Label-MS Homo sapiens
73 CCDC155  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 TMEM74  
Affinity Capture-MS Homo sapiens
75 CREB3L1  
Two-hybrid Homo sapiens
76 KIAA1467 57613
Affinity Capture-MS Homo sapiens
77 GPR152  
Two-hybrid Homo sapiens
78 FAM209A 200232
Two-hybrid Homo sapiens
79 PTGES 9536
Two-hybrid Homo sapiens
80 KCNE3  
Affinity Capture-MS Homo sapiens
81 ZW10 9183
Affinity Capture-MS Homo sapiens
82 FAM134C 162427
Two-hybrid Homo sapiens
83 TMEM237 65062
Two-hybrid Homo sapiens
84 ATP2A1 487
Proximity Label-MS Homo sapiens
85 CISD2 493856
Two-hybrid Homo sapiens
86 NAPG 8774
Affinity Capture-MS Homo sapiens
87 MAGEA6  
Two-hybrid Homo sapiens
88 USHBP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
89 LMNA 4000
Proximity Label-MS Homo sapiens
90 TMX2 51075
Two-hybrid Homo sapiens
91 STX2 2054
Two-hybrid Homo sapiens
92 TMEM80  
Two-hybrid Homo sapiens
93 USE1 55850
Affinity Capture-MS Homo sapiens
94 NSF 4905
Affinity Capture-MS Homo sapiens
95 HAUS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 ASZ1  
Two-hybrid Homo sapiens
97 PGRMC1 10857
Affinity Capture-MS Homo sapiens
98 EEA1 8411
Affinity Capture-MS Homo sapiens
99 GOSR1 9527
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
100 SLC26A6 65010
Two-hybrid Homo sapiens
101 NUP35 129401
Proximity Label-MS Homo sapiens
102 C17orf62 79415
Two-hybrid Homo sapiens
103 NAPB 63908
Two-hybrid Homo sapiens
104 CLEC10A  
Two-hybrid Homo sapiens
105 VAMP7 6845
Affinity Capture-MS Homo sapiens
106 TBK1 29110
Affinity Capture-MS Homo sapiens
107 ERGIC2 51290
Proximity Label-MS Homo sapiens
108 BCL2L13 23786
Two-hybrid Homo sapiens
109 SEC62 7095
Proximity Label-MS Homo sapiens
110 STX3 6809
Affinity Capture-MS Homo sapiens
111 RAB7A 7879
Proximity Label-MS Homo sapiens
112 YKT6 10652
Affinity Capture-MS Homo sapiens
113 VAMP5 10791
Affinity Capture-MS Homo sapiens
114 MARCH4  
Affinity Capture-MS Homo sapiens
115 RAB5C 5878
Proximity Label-MS Homo sapiens
116 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PCDH10 57575
Affinity Capture-MS Homo sapiens
118 CHRNB1  
Affinity Capture-MS Homo sapiens
119 ELOVL4  
Two-hybrid Homo sapiens
120 MGST3 4259
Two-hybrid Homo sapiens
121 SNAP29 9342
Affinity Capture-MS Homo sapiens
122 FAM210B  
Two-hybrid Homo sapiens
123 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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