Gene description for ZW10
Gene name zw10 kinetochore protein
Gene symbol ZW10
Other names/aliases HZW10
Species Homo sapiens
 Database cross references - ZW10
ExoCarta ExoCarta_9183
Entrez Gene 9183
HGNC 13194
MIM 603954
UniProt O43264  
 ZW10 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ZW10
Molecular Function
    centromeric DNA binding GO:0019237 TAS
    protein binding GO:0005515 IPI
Biological Process
    protein complex assembly GO:0006461 IDA
    cell division GO:0051301 IEA
    mitotic metaphase plate congression GO:0007080 IMP
    regulation of exit from mitosis GO:0007096 IDA
    mitotic cell cycle checkpoint GO:0007093 IDA
    meiotic nuclear division GO:0007126 TAS
    protein localization to kinetochore GO:0034501 IMP
    protein transport GO:0015031 IEA
    Golgi organization GO:0007030 IMP
    small GTPase mediated signal transduction GO:0007264 TAS
    ER to Golgi vesicle-mediated transport GO:0006888 IMP
    mitotic sister chromatid segregation GO:0000070 IDA
    mitotic cell cycle GO:0000278 TAS
    establishment of mitotic spindle orientation GO:0000132 IMP
Subcellular Localization
    kinetochore GO:0000776 IDA
    kinetochore microtubule GO:0005828 IDA
    nucleus GO:0005634 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    spindle pole GO:0000922 IDA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    membrane GO:0016020 IDA
    cytosol GO:0005829 TAS
    condensed chromosome kinetochore GO:0000777 IEA
 Experiment description of studies that identified ZW10 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZW10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX18  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 PHLDA3  
Affinity Capture-MS Homo sapiens
3 GSTK1 373156
Affinity Capture-MS Homo sapiens
4 RINT-1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 KNTC1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml

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