Gene description for SENP3
Gene name SUMO1/sentrin/SMT3 specific peptidase 3
Gene symbol SENP3
Other names/aliases SMT3IP1
SSP3
Ulp1
Species Homo sapiens
 Database cross references - SENP3
ExoCarta ExoCarta_26168
Vesiclepedia VP_26168
Entrez Gene 26168
HGNC 17862
MIM 612844
UniProt Q9H4L4  
 SENP3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SENP3
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IEA
    protein binding GO:0005515 IPI
    cysteine-type peptidase activity GO:0008234 IDA
    deSUMOylase activity GO:0016929 IBA
    deSUMOylase activity GO:0016929 IDA
    deSUMOylase activity GO:0016929 IMP
Biological Process
    proteolysis GO:0006508 IEA
    protein desumoylation GO:0016926 IBA
    protein desumoylation GO:0016926 IDA
    protein desumoylation GO:0016926 IMP
    negative regulation of double-strand break repair via homologous recombination GO:2000042 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IEA
    MLL1 complex GO:0071339 IDA
 Experiment description of studies that identified SENP3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SENP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 SPATS2  
Affinity Capture-MS Homo sapiens
4 COPG2 26958
Affinity Capture-MS Homo sapiens
5 MCM3 4172
Affinity Capture-MS Homo sapiens
6 NCBP1 4686
Affinity Capture-MS Homo sapiens
7 C2CD4A  
Affinity Capture-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 SAV1  
Affinity Capture-MS Homo sapiens
10 QARS 5859
Affinity Capture-MS Homo sapiens
11 GTF3C3 9330
Affinity Capture-MS Homo sapiens
12 DDX17 10521
Affinity Capture-MS Homo sapiens
13 TRRAP 8295
Affinity Capture-MS Homo sapiens
14 RPS4X 6191
Affinity Capture-MS Homo sapiens
15 TOP2B 7155
Affinity Capture-MS Homo sapiens
16 PFKP 5214
Affinity Capture-MS Homo sapiens
17 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
18 VPRBP 9730
Affinity Capture-MS Homo sapiens
19 MCM7 4176
Affinity Capture-MS Homo sapiens
20 ADRB2  
Two-hybrid Homo sapiens
21 ZC3H14  
Affinity Capture-MS Homo sapiens
22 TCF7L2  
Affinity Capture-MS Homo sapiens
23 NOP56 10528
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ESF1 51575
Affinity Capture-MS Homo sapiens
25 RPL10 6134
Affinity Capture-MS Homo sapiens
26 RPL15 6138
Affinity Capture-MS Homo sapiens
27 RPS6KA4 8986
Affinity Capture-MS Homo sapiens
28 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
29 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SAMD1  
Affinity Capture-MS Homo sapiens
31 N4BP2L2 10443
Affinity Capture-MS Homo sapiens
32 RSBN1  
Affinity Capture-MS Homo sapiens
33 TAF1  
Affinity Capture-MS Homo sapiens
34 TRIM54  
Biochemical Activity Homo sapiens
35 CENPA  
Proximity Label-MS Homo sapiens
36 POTEF 728378
Affinity Capture-MS Homo sapiens
37 RPS18 6222
Affinity Capture-MS Homo sapiens
38 CHCHD4  
Co-fractionation Homo sapiens
39 DDX23 9416
Proximity Label-MS Homo sapiens
40 RPL4 6124
Affinity Capture-MS Homo sapiens
41 PLEKHG4  
Affinity Capture-MS Homo sapiens
42 TRIM28 10155
Affinity Capture-MS Homo sapiens
43 TSPYL1 7259
Affinity Capture-MS Homo sapiens
44 MLLT4 4301
Affinity Capture-MS Homo sapiens
45 MDN1 23195
Affinity Capture-MS Homo sapiens
46 GPHN 10243
Affinity Capture-MS Homo sapiens
47 H2AFB3  
Affinity Capture-MS Homo sapiens
48 TELO2 9894
Affinity Capture-MS Homo sapiens
49 ZFP91 80829
Affinity Capture-MS Homo sapiens
50 AP1G1 164
Affinity Capture-MS Homo sapiens
51 NPM1 4869
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
52 KMT2D 8085
Affinity Capture-Western Homo sapiens
53 RPS8 6202
Affinity Capture-MS Homo sapiens
54 NUP93 9688
Affinity Capture-MS Homo sapiens
55 POLR1E  
Proximity Label-MS Homo sapiens
56 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 MAGED2 10916
Affinity Capture-MS Homo sapiens
58 SRP14 6727
Affinity Capture-MS Homo sapiens
59 NR1H2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 HSP90B1 7184
Affinity Capture-MS Homo sapiens
61 DDX51  
Affinity Capture-MS Homo sapiens
62 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
63 POLDIP3 84271
Affinity Capture-MS Homo sapiens
64 BRD4 23476
Affinity Capture-MS Homo sapiens
65 TNFRSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ASH2L 9070
Co-localization Homo sapiens
67 CDCA8 55143
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
68 SUGP2  
Affinity Capture-MS Homo sapiens
69 RECQL4  
Affinity Capture-MS Homo sapiens
70 CUL1 8454
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
71 ARAP3 64411
Affinity Capture-MS Homo sapiens
72 WDR5 11091
Affinity Capture-Western Homo sapiens
73 CSNK2B 1460
Affinity Capture-MS Homo sapiens
74 RPS11 6205
Affinity Capture-MS Homo sapiens
75 ATG2B 55102
Affinity Capture-MS Homo sapiens
76 TFRC 7037
Affinity Capture-MS Homo sapiens
77 RLIM 51132
Affinity Capture-MS Homo sapiens
78 KIF14 9928
Affinity Capture-MS Homo sapiens
79 EIF2AK2 5610
Affinity Capture-MS Homo sapiens
80 NSUN2 54888
Affinity Capture-MS Homo sapiens
81 P4HA1 5033
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
83 MRE11A 4361
Affinity Capture-MS Homo sapiens
84 USP21  
Biochemical Activity Homo sapiens
85 PARK2  
Affinity Capture-MS Homo sapiens
86 ZNF451 26036
Affinity Capture-MS Homo sapiens
87 SNAP91 9892
Affinity Capture-MS Homo sapiens
88 HIC1  
Biochemical Activity Homo sapiens
89 COPG1 22820
Affinity Capture-MS Homo sapiens
90 XAB2 56949
Affinity Capture-MS Homo sapiens
91 ACIN1 22985
Affinity Capture-MS Homo sapiens
92 MAGED1 9500
Affinity Capture-MS Homo sapiens
93 CEP19  
Two-hybrid Homo sapiens
94 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
95 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
96 TBC1D32 221322
Proximity Label-MS Homo sapiens
97 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
98 PSMD2 5708
Affinity Capture-MS Homo sapiens
99 VCP 7415
Affinity Capture-MS Homo sapiens
100 RRM1 6240
Affinity Capture-MS Homo sapiens
101 NTRK1 4914
Affinity Capture-MS Homo sapiens
102 RPL31 6160
Proximity Label-MS Homo sapiens
103 TRIM63  
Biochemical Activity Homo sapiens
104 GIT1 28964
Affinity Capture-MS Homo sapiens
105 IFI16 3428
Affinity Capture-MS Homo sapiens
106 GTF3C2  
Affinity Capture-MS Homo sapiens
107 SUMO2 6613
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
108 CBX6  
Affinity Capture-MS Homo sapiens
109 MEX3D  
Affinity Capture-MS Homo sapiens
110 KPNB1 3837
Affinity Capture-MS Homo sapiens
111 UBTF 7343
Affinity Capture-MS Homo sapiens
112 GANAB 23193
Affinity Capture-MS Homo sapiens
113 PML 5371
Affinity Capture-MS Homo sapiens
114 HECTD1 25831
Affinity Capture-MS Homo sapiens
115 RPLP0 6175
Affinity Capture-MS Homo sapiens
116 RRP1B 23076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PELP1 27043
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
118 PRKAR1B  
Affinity Capture-MS Homo sapiens
119 C3orf49  
Affinity Capture-MS Homo sapiens
120 DDX27 55661
Affinity Capture-MS Homo sapiens
121 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
122 TUBB8 347688
Affinity Capture-MS Homo sapiens
123 CD3EAP  
Proximity Label-MS Homo sapiens
124 IPO4 79711
Affinity Capture-MS Homo sapiens
125 BRD7  
Affinity Capture-MS Homo sapiens
126 SEC63 11231
Affinity Capture-MS Homo sapiens
127 C3orf17  
Affinity Capture-MS Homo sapiens
128 ZBTB2 57621
Affinity Capture-MS Homo sapiens
129 IPO5 3843
Affinity Capture-MS Homo sapiens
130 SPATS2L 26010
Affinity Capture-MS Homo sapiens
131 RGL3  
Affinity Capture-MS Homo sapiens
132 KMT2A  
Affinity Capture-Western Homo sapiens
133 LAS1L 81887
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 Cbx1  
Affinity Capture-MS Mus musculus
135 TARS 6897
Affinity Capture-MS Homo sapiens
136 C9orf78 51759
Affinity Capture-MS Homo sapiens
137 USP15 9958
Biochemical Activity Homo sapiens
138 CLPP 8192
Proximity Label-MS Homo sapiens
139 MAD1L1  
Affinity Capture-MS Homo sapiens
140 CCP110  
Affinity Capture-MS Homo sapiens
141 NAT10 55226
Affinity Capture-MS Homo sapiens
142 EEF2 1938
Affinity Capture-MS Homo sapiens
143 GTF3C1  
Affinity Capture-MS Homo sapiens
144 ZFR 51663
Affinity Capture-MS Homo sapiens
145 NPM3 10360
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
147 NR3C1 2908
Proximity Label-MS Homo sapiens
148 DCAF13 25879
Affinity Capture-MS Homo sapiens
149 RPL3 6122
Affinity Capture-MS Homo sapiens
150 ELAC2 60528
Affinity Capture-MS Homo sapiens
151 MCM4 4173
Affinity Capture-MS Homo sapiens
152 BBX 56987
Affinity Capture-MS Homo sapiens
153 PDPK1 5170
Affinity Capture-Western Homo sapiens
154 PPP6R3 55291
Affinity Capture-MS Homo sapiens
155 SUZ12  
Affinity Capture-MS Homo sapiens
156 GTF3C4 9329
Affinity Capture-MS Homo sapiens
157 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
158 NXF1 10482
Affinity Capture-RNA Homo sapiens
159 SETX  
Affinity Capture-MS Homo sapiens
160 ABT1 29777
Affinity Capture-MS Homo sapiens
161 TUBA4A 7277
Affinity Capture-MS Homo sapiens
162 MAP7D1 55700
Affinity Capture-MS Homo sapiens
163 ZW10 9183
Affinity Capture-MS Homo sapiens
164 NCAPH 23397
Affinity Capture-MS Homo sapiens
165 MOGS 7841
Affinity Capture-MS Homo sapiens
166 CHCHD2  
Affinity Capture-MS Homo sapiens
167 NEFM 4741
Proximity Label-MS Homo sapiens
168 HECW2  
Affinity Capture-MS Homo sapiens
169 H2AFB1  
Affinity Capture-MS Homo sapiens
170 ZC3H18  
Affinity Capture-MS Homo sapiens
171 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
172 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
173 PEX1 5189
Affinity Capture-MS Homo sapiens
174 MYO9B 4650
Affinity Capture-MS Homo sapiens
175 EED  
Affinity Capture-MS Homo sapiens
176 ACTR8 93973
Affinity Capture-MS Homo sapiens
177 MATR3 9782
Affinity Capture-MS Homo sapiens
178 DDRGK1 65992
Affinity Capture-MS Homo sapiens
179 RNF2  
Affinity Capture-MS Homo sapiens
180 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
181 FOXQ1  
Affinity Capture-MS Homo sapiens
182 P4HA3 283208
Affinity Capture-MS Homo sapiens
183 CSDE1 7812
Affinity Capture-MS Homo sapiens
184 PDCD11 22984
Affinity Capture-MS Homo sapiens
185 RBBP5 5929
Affinity Capture-Western Homo sapiens
186 MCM3AP  
Affinity Capture-MS Homo sapiens
187 CBWD1 55871
Affinity Capture-MS Homo sapiens
188 DDX52  
Affinity Capture-MS Homo sapiens
189 PYHIN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
190 XRCC5 7520
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
191 SLTM 79811
Affinity Capture-MS Homo sapiens
192 TCF25 22980
Affinity Capture-MS Homo sapiens
193 HIF1A 3091
Affinity Capture-Western Homo sapiens
194 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
195 IMMT 10989
Affinity Capture-MS Homo sapiens
196 HERC1 8925
Affinity Capture-MS Homo sapiens
197 FTL 2512
Affinity Capture-MS Homo sapiens
198 RPL13 6137
Affinity Capture-MS Homo sapiens
199 DHX15 1665
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
200 UBE3A 7337
Affinity Capture-MS Homo sapiens
201 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
202 C17orf85  
Affinity Capture-MS Homo sapiens
203 PARP1 142
Proximity Label-MS Homo sapiens
Biochemical Activity Homo sapiens
204 TRPM3  
Affinity Capture-MS Homo sapiens
205 RFC1 5981
Affinity Capture-MS Homo sapiens
206 ILF3 3609
Co-fractionation Homo sapiens
207 FBXL6  
Affinity Capture-MS Homo sapiens
208 TP53 7157
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
209 SIN3A  
Affinity Capture-MS Homo sapiens
210 NCAPD3 23310
Affinity Capture-MS Homo sapiens
211 PYGL 5836
Affinity Capture-MS Homo sapiens
212 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
213 PRR14L 253143
Affinity Capture-MS Homo sapiens
214 ZNF746  
Affinity Capture-MS Homo sapiens
215 CHTF18 63922
Affinity Capture-MS Homo sapiens
216 MEN1 4221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
217 ZKSCAN1  
Affinity Capture-MS Homo sapiens
218 PIDD1  
Affinity Capture-MS Homo sapiens
219 NDNL2 56160
Affinity Capture-MS Homo sapiens
220 PBRM1 55193
Affinity Capture-MS Homo sapiens
221 PHF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 VPS35 55737
Affinity Capture-MS Homo sapiens
223 RBM15 64783
Affinity Capture-MS Homo sapiens
224 NISCH 11188
Affinity Capture-Western Homo sapiens
225 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
226 CDK6 1021
Biochemical Activity Homo sapiens
227 MEF2D  
Affinity Capture-Western Homo sapiens
228 MKI67  
Affinity Capture-MS Homo sapiens
229 NIFK 84365
Proximity Label-MS Homo sapiens
230 WDR18 57418
Affinity Capture-MS Homo sapiens
Co-fractionation