Gene description for N4BP2L2
Gene name NEDD4 binding protein 2-like 2
Gene symbol N4BP2L2
Other names/aliases 92M18.3
CG005
PFAAP5
Species Homo sapiens
 Database cross references - N4BP2L2
ExoCarta ExoCarta_10443
Vesiclepedia VP_10443
Entrez Gene 10443
HGNC 26916
MIM 615788
UniProt Q92802  
 N4BP2L2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 19056867    
 Gene ontology annotations for N4BP2L2
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 ISS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    blastocyst development GO:0001824 IEA
    positive regulation of hematopoietic stem cell proliferation GO:1902035 IMP
    negative regulation of hematopoietic stem cell differentiation GO:1902037 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    transcription repressor complex GO:0017053 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified N4BP2L2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for N4BP2L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGH 3492
Affinity Capture-MS Homo sapiens
2 SENP3 26168
Affinity Capture-MS Homo sapiens
3 IRAK2  
Affinity Capture-MS Homo sapiens
4 PPIA 5478
Two-hybrid Homo sapiens
5 NPAS1  
Affinity Capture-MS Homo sapiens
6 SIRT6  
Affinity Capture-MS Homo sapiens
7 LGR4 55366
Affinity Capture-MS Homo sapiens
8 SWSAP1  
Affinity Capture-MS Homo sapiens
9 C9orf163  
Affinity Capture-MS Homo sapiens
10 NAA38  
Two-hybrid Homo sapiens
11 METTL10  
Affinity Capture-MS Homo sapiens
12 SULT1C4  
Affinity Capture-MS Homo sapiens
13 F11 2160
Affinity Capture-MS Homo sapiens
14 PIP 5304
Affinity Capture-MS Homo sapiens
15 PPARD  
Affinity Capture-MS Homo sapiens
16 SNAPC4  
Affinity Capture-MS Homo sapiens
17 NCAPH2  
Affinity Capture-MS Homo sapiens
18 C12orf74  
Affinity Capture-MS Homo sapiens
19 MRPS18C  
Affinity Capture-MS Homo sapiens
20 PTH2R  
Affinity Capture-MS Homo sapiens
21 FAM96A  
Affinity Capture-MS Homo sapiens
22 WNT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ZNF252P-AS1  
Affinity Capture-MS Homo sapiens
24 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PRMT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NAA11 84779
Affinity Capture-MS Homo sapiens
27 PPIH 10465
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 RBM39 9584
Affinity Capture-MS Homo sapiens
29 FOXF2  
Affinity Capture-MS Homo sapiens
30 TRIM31  
Affinity Capture-MS Homo sapiens
31 LYZL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 NXF2  
Affinity Capture-MS Homo sapiens
33 PPIL1 51645
Two-hybrid Homo sapiens
34 HOXA1 3198
Two-hybrid Homo sapiens
35 IGSF5  
Affinity Capture-MS Homo sapiens
36 TRMT61A 115708
Affinity Capture-MS Homo sapiens
37 CLASRP  
Affinity Capture-MS Homo sapiens
38 Hoxa1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
39 SF3A1 10291
Affinity Capture-MS Homo sapiens
40 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
41 NELFCD 51497
Affinity Capture-MS Homo sapiens
42 LMO2  
Two-hybrid Homo sapiens
43 PROZ 8858
Affinity Capture-MS Homo sapiens
44 GOLGA6L2  
Affinity Capture-MS Homo sapiens
45 DHFR 1719
Affinity Capture-MS Homo sapiens
46 KIAA1683  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 LY6G5B  
Affinity Capture-MS Homo sapiens
48 CGRRF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 INF2 64423
Affinity Capture-MS Homo sapiens
50 B4GALT2  
Affinity Capture-MS Homo sapiens
51 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PIGT 51604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RFXANK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 OLFM2  
Affinity Capture-MS Homo sapiens
55 HES6  
Affinity Capture-MS Homo sapiens
56 DNAJA2 10294
Affinity Capture-MS Homo sapiens
57 DNAJC10 54431
Affinity Capture-MS Homo sapiens
58 HSD17B7P2  
Affinity Capture-MS Homo sapiens
59 PRPF4 9128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 EDN3  
Affinity Capture-MS Homo sapiens
61 LOX 4015
Affinity Capture-MS Homo sapiens
62 GUSBP5  
Affinity Capture-MS Homo sapiens
63 TMPRSS5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 VCPIP1 80124
Affinity Capture-MS Homo sapiens
65 CCT8L2  
Affinity Capture-MS Homo sapiens
66 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 WNT16  
Affinity Capture-MS Homo sapiens
68 ADAMTS17  
Affinity Capture-MS Homo sapiens
69 UBXN6 80700
Affinity Capture-MS Homo sapiens
70 RAD51B  
Affinity Capture-MS Homo sapiens
71 ATG7 10533
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which N4BP2L2 is involved
No pathways found





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