Gene description for LOX
Gene name lysyl oxidase
Gene symbol LOX
Other names/aliases -
Species Homo sapiens
 Database cross references - LOX
ExoCarta ExoCarta_4015
Entrez Gene 4015
HGNC 6664
MIM 153455
UniProt P28300  
 LOX identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for LOX
Molecular Function
    copper ion binding GO:0005507 IEA
    protein binding GO:0005515 IPI
    protein-lysine 6-oxidase activity GO:0004720 IEA
Biological Process
    collagen fibril organization GO:0030199 IEA
    extracellular matrix organization GO:0030198 TAS
    lung development GO:0030324 IEA
    response to steroid hormone GO:0048545 IEA
    oxidation-reduction process GO:0055114 IEA
    blood vessel development GO:0001568 IEA
    cellular protein modification process GO:0006464 TAS
    response to drug GO:0042493 IEA
    elastic fiber assembly GO:0048251 IEA
    wound healing GO:0042060 IEA
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IEA
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified LOX in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for LOX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DHDDS  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LOX is involved
PathwayEvidenceSource
Crosslinking of collagen fibrils TAS Reactome
Elastic fibre formation TAS Reactome





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