Gene description for ELN
Gene name elastin
Gene symbol ELN
Other names/aliases SVAS
WBS
WS
Species Homo sapiens
 Database cross references - ELN
ExoCarta ExoCarta_2006
Vesiclepedia VP_2006
Entrez Gene 2006
HGNC 3327
MIM 130160
UniProt P15502  
 ELN identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ELN
Molecular Function
    extracellular matrix structural constituent GO:0005201 ISS
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    extracellular matrix constituent conferring elasticity GO:0030023 RCA
    extracellular matrix binding GO:0050840 IEA
Biological Process
    outflow tract morphogenesis GO:0003151 IMP
    aortic valve morphogenesis GO:0003180 ISS
    skeletal muscle tissue development GO:0007519 IEA
    respiratory gaseous exchange by respiratory system GO:0007585 TAS
    blood circulation GO:0008015 TAS
    animal organ morphogenesis GO:0009887 TAS
    regulation of actin filament polymerization GO:0030833 IEA
    stress fiber assembly GO:0043149 IEA
    regulation of smooth muscle cell proliferation GO:0048660 TAS
    extracellular matrix assembly GO:0085029 ISS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular matrix GO:0031012 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
    elastic fiber GO:0071953 IDA
 Experiment description of studies that identified ELN in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ELN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NID2 22795
Reconstituted Complex Homo sapiens
2 FCN1 2219
Reconstituted Complex Homo sapiens
3 LGALS3 3958
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 LOX 4015
Reconstituted Complex Homo sapiens
5 PRTN3 5657
Biochemical Activity Homo sapiens
6 FBLN2 2199
Reconstituted Complex Homo sapiens
7 FBN1 2200
Reconstituted Complex Homo sapiens
8 BGN 633
Reconstituted Complex Homo sapiens
9 FBLN1 2192
Reconstituted Complex Homo sapiens
10 CKMT2  
Two-hybrid Homo sapiens
11 CLU 1191
Reconstituted Complex Homo sapiens
12 MAGEH1  
Two-hybrid Homo sapiens
13 DCN 1634
Reconstituted Complex Homo sapiens
14 FBN2 2201
Reconstituted Complex Homo sapiens
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