Gene description for FBLN2
Gene name fibulin 2
Gene symbol FBLN2
Other names/aliases -
Species Homo sapiens
 Database cross references - FBLN2
ExoCarta ExoCarta_2199
Entrez Gene 2199
HGNC 3601
MIM 135821
UniProt P98095  
 FBLN2 identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Thymus 23844026    
 Gene ontology annotations for FBLN2
Molecular Function
    extracellular matrix structural constituent GO:0005201 TAS
    extracellular matrix binding GO:0050840 IEA
    calcium ion binding GO:0005509 IEA
Biological Process
    positive regulation of cell-substrate adhesion GO:0010811 IEA
    extracellular matrix organization GO:0030198 TAS
Subcellular Localization
    extracellular vesicle GO:1903561 IDA
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    extracellular matrix GO:0031012 ISS
 Experiment description of studies that identified FBLN2 in exosomes
1
Experiment ID 189
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 219
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 220
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 221
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FBLN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Invivo Homo sapiens
2 VCAN 1462
Reconstituted Complex Homo sapiens
3 NID1 4811
Invitro Homo sapiens
4 ELN  
Reconstituted Complex Homo sapiens
5 FBN1 2200
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
6 HSPG2 3339
Reconstituted Complex Homo sapiens
7 FBLN2 2199
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 COL4A5  
Invivo Homo sapiens
9 BCAN  
Reconstituted Complex Homo sapiens
10 PRELP 5549
Reconstituted Complex Homo sapiens
11 AGC1  
Reconstituted Complex Homo sapiens
12 COL4A1 1282
Invivo Homo sapiens
13 COL4A4  
Invivo Homo sapiens
14 COL4A3 1285
Invivo Homo sapiens
15 LAMA1 284217
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
16 COL4A6  
Invivo Homo sapiens
17 COL4A2 1284
Invivo Homo sapiens
18 LAMA5 3911
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which FBLN2 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres TAS Reactome





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