Gene description for PRTN3
Gene name proteinase 3
Gene symbol PRTN3
Other names/aliases ACPA
AGP7
C-ANCA
CANCA
MBN
MBT
NP-4
NP4
P29
PR-3
PR3
Species Homo sapiens
 Database cross references - PRTN3
ExoCarta ExoCarta_5657
Vesiclepedia VP_5657
Entrez Gene 5657
HGNC 9495
MIM 177020
UniProt P24158  
 PRTN3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PRTN3
Molecular Function
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type peptidase activity GO:0008236 TAS
    enzyme binding GO:0019899 IPI
Biological Process
    negative regulation of phagocytosis GO:0050765 IDA
    collagen catabolic process GO:0030574 IEA
    blood coagulation GO:0007596 TAS
    mature conventional dendritic cell differentiation GO:0097029 IDA
    positive regulation of cell proliferation GO:0008284 TAS
    proteolysis GO:0006508 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    extracellular matrix GO:0031012 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified PRTN3 in exosomes
1
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PRTN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNF  
Invivo Homo sapiens
2 CAMP 820
Invivo Homo sapiens
Invitro Homo sapiens
3 SERPINA1 5265
Invitro Homo sapiens
4 IL1B  
Invivo Homo sapiens
5 SERPINB1 1992
Invitro Homo sapiens
6 ITGAM 3684
Affinity Capture-Western Homo sapiens
7 ELN 2006
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PRTN3 is involved
PathwayEvidenceSource
Common Pathway of Fibrin Clot Formation TAS Reactome





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