Gene description for ADGRG6
Gene name adhesion G protein-coupled receptor G6
Gene symbol ADGRG6
Other names/aliases APG1
DREG
GPR126
PS1TP2
VIGR
Species Homo sapiens
 Database cross references - ADGRG6
ExoCarta ExoCarta_57211
Entrez Gene 57211
HGNC 13841
MIM 612243
UniProt Q86SQ4  
 ADGRG6 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for ADGRG6
Molecular Function
    G-protein coupled receptor activity GO:0004930 IEA
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ADGRG6 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for ADGRG6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADGRG6 is involved
No pathways found





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