Gene description for CD3D
Gene name CD3d molecule, delta (CD3-TCR complex)
Gene symbol CD3D
Other names/aliases CD3-DELTA
Species Homo sapiens
 Database cross references - CD3D
ExoCarta ExoCarta_915
Entrez Gene 915
HGNC 1673
MIM 186790
UniProt P04234  
 CD3D identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD3D
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IC
    transcription coactivator activity GO:0003713 IDA
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    T cell costimulation GO:0031295 TAS
    T cell receptor signaling pathway GO:0050852 TAS
    T cell differentiation GO:0030217 IDA
    cell surface receptor signaling pathway GO:0007166 IC
    positive thymic T cell selection GO:0045059 ISS
    regulation of immune response GO:0050776 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
Subcellular Localization
    alpha-beta T cell receptor complex GO:0042105 IEA
    T cell receptor complex GO:0042101 NAS
    cytoplasm GO:0005737 NAS
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CD3D in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD3D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD247 919
Invivo Homo sapiens
Invitro Homo sapiens
2 CD3G 917
Invitro Homo sapiens
Invivo Homo sapiens
3 TRA@  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
4 CD8A 925
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
5 CD3E 916
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
6 CANX 821
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml

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