Gene description for DSTYK
Gene name dual serine/threonine and tyrosine protein kinase
Gene symbol DSTYK
Other names/aliases CAKUT1
DustyPK
HDCMD38P
RIP5
RIPK5
Species Homo sapiens
 Database cross references - DSTYK
ExoCarta ExoCarta_25778
Vesiclepedia VP_25778
Entrez Gene 25778
HGNC 29043
MIM 612666
UniProt Q6XUX3  
 DSTYK identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DSTYK
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    positive regulation of kinase activity GO:0033674 IMP
    negative regulation of apoptotic process GO:0043066 IBA
    negative regulation of apoptotic process GO:0043066 IMP
    cellular response to fibroblast growth factor stimulus GO:0044344 IBA
    cellular response to fibroblast growth factor stimulus GO:0044344 IDA
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IBA
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IBA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IDA
    anchoring junction GO:0070161 IEA
 Experiment description of studies that identified DSTYK in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DSTYK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH13 1012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TACR3  
Affinity Capture-MS Homo sapiens
3 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 HSPE1 3336
Affinity Capture-MS Homo sapiens
5 LSM12 124801
Affinity Capture-MS Homo sapiens
6 CCL22 6367
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MAD2L1 4085
Affinity Capture-MS Homo sapiens
8 HS1BP3 64342
Affinity Capture-MS Homo sapiens
9 TMEM9 252839
Affinity Capture-MS Homo sapiens
10 MTPN 136319
Affinity Capture-MS Homo sapiens
11 MEX3A  
Affinity Capture-RNA Homo sapiens
12 CTDSP1 58190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PSMB3 5691
Affinity Capture-MS Homo sapiens
14 GPR17 2840
Affinity Capture-MS Homo sapiens
15 DDT 1652
Affinity Capture-MS Homo sapiens
16 CD3D 915
Affinity Capture-MS Homo sapiens
17 IFT20 90410
Affinity Capture-MS Homo sapiens
18 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CXCR4 7852
Affinity Capture-MS Homo sapiens
20 CEP170P1  
Affinity Capture-MS Homo sapiens
21 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HCST  
Affinity Capture-MS Homo sapiens
23 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CEP170 9859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 NPTN 27020
Affinity Capture-MS Homo sapiens
26 CD226 10666
Affinity Capture-MS Homo sapiens
27 RPS9 6203
Affinity Capture-MS Homo sapiens
28 B3GNT3 10331
Affinity Capture-MS Homo sapiens
29 MS4A10  
Affinity Capture-MS Homo sapiens
30 ATP5F1 515
Affinity Capture-MS Homo sapiens
31 TUBB4B 10383
Affinity Capture-MS Homo sapiens
32 RAB14 51552
Affinity Capture-MS Homo sapiens
33 TGM2 7052
Affinity Capture-MS Homo sapiens
34 SLURP1  
Affinity Capture-MS Homo sapiens
35 SLAMF1 6504
Affinity Capture-MS Homo sapiens
36 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SPCS3 60559
Affinity Capture-MS Homo sapiens
38 PRPS2 5634
Affinity Capture-MS Homo sapiens
39 TCEA1 6917
Affinity Capture-MS Homo sapiens
40 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ARHGAP25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RAB2B 84932
Affinity Capture-MS Homo sapiens
43 CDK13 8621
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 UBE2K 3093
Affinity Capture-MS Homo sapiens
45 TFPI2 7980
Affinity Capture-MS Homo sapiens
46 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
47 DCTN1 1639
Affinity Capture-MS Homo sapiens
48 RAB5C 5878
Affinity Capture-MS Homo sapiens
49 EDN3  
Affinity Capture-MS Homo sapiens
50 P2RX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CLTC 1213
Affinity Capture-MS Homo sapiens
52 DCAF15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SLC31A1 1317
Affinity Capture-MS Homo sapiens
54 DGCR2 9993
Affinity Capture-MS Homo sapiens
55 ARSE 415
Affinity Capture-MS Homo sapiens
56 DEF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DKKL1  
Affinity Capture-MS Homo sapiens
58 PSMB1 5689
Affinity Capture-MS Homo sapiens
59 IKBKE 9641
Affinity Capture-MS Homo sapiens
60 EFNA2  
Affinity Capture-MS Homo sapiens
61 IGHM 3507
Affinity Capture-MS Homo sapiens
62 PLA2G10  
Affinity Capture-MS Homo sapiens
63 LRCH1 23143
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DSTYK is involved
No pathways found





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