Gene description for DSTYK
Gene name dual serine/threonine and tyrosine protein kinase
Gene symbol DSTYK
Other names/aliases CAKUT1
DustyPK
HDCMD38P
RIP5
RIPK5
Species Homo sapiens
 Database cross references - DSTYK
ExoCarta ExoCarta_25778
Vesiclepedia VP_25778
Entrez Gene 25778
HGNC 29043
MIM 612666
UniProt Q6XUX3  
 DSTYK identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DSTYK
Molecular Function
    protein tyrosine kinase activity GO:0004713 IEA
    ATP binding GO:0005524 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
Biological Process
    positive regulation of kinase activity GO:0033674 IMP
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IMP
    cellular response to fibroblast growth factor stimulus GO:0044344 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
Subcellular Localization
    apical plasma membrane GO:0016324 IDA
    cytoplasm GO:0005737 IDA
    cell junction GO:0030054 IEA
    basolateral plasma membrane GO:0016323 IDA
 Experiment description of studies that identified DSTYK in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DSTYK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPE1 3336
Affinity Capture-MS Homo sapiens
2 RAB5C 5878
Affinity Capture-MS Homo sapiens
3 RPS9  
Affinity Capture-MS Homo sapiens
4 ATP5F1 515
Affinity Capture-MS Homo sapiens
5 MAD2L1 4085
Affinity Capture-MS Homo sapiens
6 RAB14 51552
Affinity Capture-MS Homo sapiens
7 PSMB3 5691
Affinity Capture-MS Homo sapiens
8 PSMB1 5689
Affinity Capture-MS Homo sapiens
9 IKBKE 9641
Affinity Capture-MS Homo sapiens
10 MTPN 136319
Affinity Capture-MS Homo sapiens
11 UBE2K 3093
Affinity Capture-MS Homo sapiens
12 LSM12 124801
Affinity Capture-MS Homo sapiens
13 DDT  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DSTYK is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here