Gene description for ARSE
Gene name arylsulfatase E (chondrodysplasia punctata 1)
Gene symbol ARSE
Other names/aliases ASE
CDPX
CDPX1
CDPXR
Species Homo sapiens
 Database cross references - ARSE
ExoCarta ExoCarta_415
Entrez Gene 415
HGNC 719
MIM 300180
UniProt P51690  
 ARSE identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ARSE
Molecular Function
    metal ion binding GO:0046872 IEA
    arylsulfatase activity GO:0004065 TAS
Biological Process
    sphingolipid metabolic process GO:0006665 TAS
    post-translational protein modification GO:0043687 TAS
    glycosphingolipid metabolic process GO:0006687 TAS
    small molecule metabolic process GO:0044281 TAS
    skeletal system development GO:0001501 TAS
    cellular protein metabolic process GO:0044267 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    Golgi stack GO:0005795 IEA
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified ARSE in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ARSE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COQ6 51004
Two-hybrid Homo sapiens
2 NDN  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ARSE is involved
PathwayEvidenceSource
Glycosphingolipid metabolism TAS Reactome
The activation of arylsulfatases TAS Reactome





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