Gene description for COQ6
Gene name coenzyme Q6 monooxygenase
Gene symbol COQ6
Other names/aliases CGI-10
CGI10
COQ10D6
Species Homo sapiens
 Database cross references - COQ6
ExoCarta ExoCarta_51004
Vesiclepedia VP_51004
Entrez Gene 51004
HGNC 20233
MIM 614647
UniProt Q9Y2Z9  
 COQ6 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for COQ6
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IEA
    FAD binding GO:0071949 IEA
    4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity GO:0106364 IEA
Biological Process
    ubiquinone biosynthetic process GO:0006744 IBA
    ubiquinone biosynthetic process GO:0006744 IEA
    ubiquinone biosynthetic process GO:0006744 NAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    Golgi apparatus GO:0005794 IEA
    extrinsic component of mitochondrial inner membrane GO:0031314 IEA
    cell projection GO:0042995 IEA
    ubiquinone biosynthesis complex GO:0110142 IPI
 Experiment description of studies that identified COQ6 in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COQ6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NIT2 56954
Affinity Capture-MS Homo sapiens
2 AK4 205
Affinity Capture-MS Homo sapiens
3 CLPP 8192
Proximity Label-MS Homo sapiens
4 ECH1 1891
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 PMPCB 9512
Affinity Capture-MS Homo sapiens
7 ADCK4 79934
Affinity Capture-MS Homo sapiens
8 ETFA 2108
Affinity Capture-MS Homo sapiens
9 ADCK3  
Affinity Capture-MS Homo sapiens
10 COQ5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
11 COQ6 51004
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 MRPL13  
Affinity Capture-MS Homo sapiens
14 ATP5J 522
Affinity Capture-MS Homo sapiens
15 ARSE 415
Two-hybrid Homo sapiens
16 BCKDHA 593
Affinity Capture-MS Homo sapiens
17 IGHM 3507
Affinity Capture-MS Homo sapiens
18 MGARP  
Affinity Capture-MS Homo sapiens
19 BOLA3  
Affinity Capture-MS Homo sapiens
20 COQ4  
Affinity Capture-MS Homo sapiens
21 FAHD1 81889
Affinity Capture-MS Homo sapiens
22 PARK2  
Affinity Capture-MS Homo sapiens
23 ZBTB16  
Two-hybrid Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 AMACR 23600
Affinity Capture-MS Homo sapiens
26 CDK2 1017
Affinity Capture-MS Homo sapiens
27 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
28 NDUFAF5  
Affinity Capture-MS Homo sapiens
29 MYC  
Affinity Capture-MS Homo sapiens
30 ATP5E 514
Affinity Capture-MS Homo sapiens
31 PMPCA 23203
Affinity Capture-MS Homo sapiens
32 COQ9  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
33 SCGB2A2  
Affinity Capture-MS Homo sapiens
34 GPR182  
Affinity Capture-MS Homo sapiens
35 CHCHD2  
Affinity Capture-MS Homo sapiens
36 POLDIP2 26073
Affinity Capture-MS Homo sapiens
37 C1QBP 708
Affinity Capture-MS Homo sapiens
38 COQ3  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
39 QRSL1  
Affinity Capture-MS Homo sapiens
40 CYCS 54205
Affinity Capture-MS Homo sapiens
41 ATP5C1 509
Affinity Capture-MS Homo sapiens
42 NRD1 4898
Affinity Capture-MS Homo sapiens
43 TMEM70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MLYCD 23417
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COQ6 is involved
PathwayEvidenceSource
Metabolism TAS Reactome
Metabolism of cofactors TAS Reactome
Metabolism of vitamins and cofactors TAS Reactome
Ubiquinol biosynthesis TAS Reactome





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