Gene description for COQ6
Gene name coenzyme Q6 monooxygenase
Gene symbol COQ6
Other names/aliases CGI-10
CGI10
COQ10D6
Species Homo sapiens
 Database cross references - COQ6
ExoCarta ExoCarta_51004
Entrez Gene 51004
HGNC 20233
MIM 614647
UniProt Q9Y2Z9  
 COQ6 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for COQ6
Molecular Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 IEA
    flavin adenine dinucleotide binding GO:0050660 IEA
    monooxygenase activity GO:0004497 IBA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    oxidation-reduction process GO:0055114 IEA
    ubiquinone biosynthetic process GO:0006744 TAS
    secondary metabolite biosynthetic process GO:0044550 IBA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 IEA
    Golgi apparatus GO:0005794 IEA
    mitochondrion GO:0005739 IDA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified COQ6 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COQ6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARSE 415
Two-hybrid Homo sapiens
2 ZBTB16  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which COQ6 is involved
PathwayEvidenceSource
Ubiquinol biosynthesis TAS Reactome





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