Gene description for AMACR
Gene name alpha-methylacyl-CoA racemase
Gene symbol AMACR
Other names/aliases AMACRD
CBAS4
RACE
RM
Species Homo sapiens
 Database cross references - AMACR
ExoCarta ExoCarta_23600
Vesiclepedia VP_23600
Entrez Gene 23600
HGNC 451
MIM 604489
UniProt Q9UHK6  
 AMACR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AMACR
Molecular Function
    signaling receptor binding GO:0005102 IPI
    alpha-methylacyl-CoA racemase activity GO:0008111 IBA
    alpha-methylacyl-CoA racemase activity GO:0008111 IDA
    alpha-methylacyl-CoA racemase activity GO:0008111 IMP
    alpha-methylacyl-CoA racemase activity GO:0008111 TAS
Biological Process
    bile acid biosynthetic process GO:0006699 IEA
    bile acid biosynthetic process GO:0006699 TAS
    bile acid metabolic process GO:0008206 IBA
    bile acid metabolic process GO:0008206 IDA
    fatty acid beta-oxidation using acyl-CoA oxidase GO:0033540 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    peroxisome GO:0005777 IDA
    peroxisomal matrix GO:0005782 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified AMACR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AMACR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NDUFAF1  
Affinity Capture-MS Homo sapiens
2 GLS 2744
Affinity Capture-MS Homo sapiens
3 CPT2 1376
Affinity Capture-MS Homo sapiens
4 ACSF2 80221
Affinity Capture-MS Homo sapiens
5 EARS2  
Affinity Capture-MS Homo sapiens
6 CLPX 10845
Affinity Capture-MS Homo sapiens
7 ADCK4 79934
Affinity Capture-MS Homo sapiens
8 BCKDK 10295
Affinity Capture-MS Homo sapiens
9 HSPD1 3329
Affinity Capture-MS Homo sapiens
10 SDR39U1  
Affinity Capture-MS Homo sapiens
11 CDK5RAP1  
Affinity Capture-MS Homo sapiens
12 MTIF2 4528
Affinity Capture-MS Homo sapiens
13 FASTKD1  
Affinity Capture-MS Homo sapiens
14 COQ6 51004
Affinity Capture-MS Homo sapiens
15 GTPBP6  
Affinity Capture-MS Homo sapiens
16 PSME3 10197
Affinity Capture-MS Homo sapiens
17 FAM192A  
Affinity Capture-MS Homo sapiens
18 GTPBP10  
Affinity Capture-MS Homo sapiens
19 LARS2 23395
Affinity Capture-MS Homo sapiens
20 RSAD1  
Affinity Capture-MS Homo sapiens
21 BCKDHA 593
Affinity Capture-MS Homo sapiens
22 MRPL16  
Affinity Capture-MS Homo sapiens
23 MTG2  
Affinity Capture-MS Homo sapiens
24 COASY 80347
Affinity Capture-MS Homo sapiens
25 PSMG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PPOX 5498
Affinity Capture-MS Homo sapiens
27 TARS2 80222
Affinity Capture-MS Homo sapiens
28 ELAC2 60528
Affinity Capture-MS Homo sapiens
29 GATB  
Affinity Capture-MS Homo sapiens
30 MTO1  
Affinity Capture-MS Homo sapiens
31 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 VARS2  
Affinity Capture-MS Homo sapiens
33 TMLHE 55217
Affinity Capture-MS Homo sapiens
34 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
35 Cep152  
Affinity Capture-MS Mus musculus
36 CECR5 27440
Affinity Capture-MS Homo sapiens
37 APEX1 328
Affinity Capture-RNA Homo sapiens
38 GUF1  
Affinity Capture-MS Homo sapiens
39 FPGS 2356
Affinity Capture-MS Homo sapiens
40 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MUT 4594
Affinity Capture-MS Homo sapiens
42 PSMG3 84262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TBRG4 9238
Affinity Capture-MS Homo sapiens
44 AARS2  
Affinity Capture-MS Homo sapiens
45 PC 5091
Affinity Capture-MS Homo sapiens
46 FECH 2235
Affinity Capture-MS Homo sapiens
47 HARS2 23438
Affinity Capture-MS Homo sapiens
48 PCCB 5096
Affinity Capture-MS Homo sapiens
49 ACSF3 197322
Affinity Capture-MS Homo sapiens
50 CYP24A1  
Affinity Capture-MS Homo sapiens
51 YARS2  
Affinity Capture-MS Homo sapiens
52 KIAA0391  
Affinity Capture-MS Homo sapiens
53 PEX5 5830
Protein-peptide Homo sapiens
54 VWA8 23078
Affinity Capture-MS Homo sapiens
55 NDUFA10 4705
Affinity Capture-MS Homo sapiens
56 POLG  
Affinity Capture-MS Homo sapiens
57 PUS1 80324
Affinity Capture-MS Homo sapiens
58 METTL15  
Affinity Capture-MS Homo sapiens
59 NSUN4  
Affinity Capture-MS Homo sapiens
60 POLRMT 5442
Affinity Capture-MS Homo sapiens
61 PTCD1 26024
Affinity Capture-MS Homo sapiens
62 SARDH 1757
Affinity Capture-MS Homo sapiens
63 PIPSL 266971
Affinity Capture-MS Homo sapiens
64 DARS2 55157
Affinity Capture-MS Homo sapiens
65 MTHFD1L 25902
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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