Gene description for TARS2
Gene name threonyl-tRNA synthetase 2, mitochondrial (putative)
Gene symbol TARS2
Other names/aliases COXPD21
TARSL1
thrRS
Species Homo sapiens
 Database cross references - TARS2
ExoCarta ExoCarta_80222
Vesiclepedia VP_80222
Entrez Gene 80222
HGNC 30740
MIM 612805
UniProt Q9BW92  
 TARS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TARS2
Molecular Function
    aminoacyl-tRNA editing activity GO:0002161 IDA
    threonine-tRNA ligase activity GO:0004829 IBA
    threonine-tRNA ligase activity GO:0004829 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    threonyl-tRNA aminoacylation GO:0006435 IBA
    mitochondrial threonyl-tRNA aminoacylation GO:0070159 TAS
    aminoacyl-tRNA metabolism involved in translational fidelity GO:0106074 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified TARS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
3 SPRTN  
Affinity Capture-MS Homo sapiens
4 SLC17A9  
Two-hybrid Homo sapiens
5 RPA2 6118
Proximity Label-MS Homo sapiens
6 MTG2  
Proximity Label-MS Homo sapiens
7 C9orf78 51759
Affinity Capture-MS Homo sapiens
8 KLRB1  
Affinity Capture-MS Homo sapiens
9 ARL6IP1 23204
Two-hybrid Homo sapiens
10 APEX1 328
Affinity Capture-RNA Homo sapiens
11 TRMU  
Affinity Capture-MS Homo sapiens
12 COQ9  
Affinity Capture-MS Homo sapiens
13 WDR83  
Affinity Capture-MS Homo sapiens
14 YARS2  
Affinity Capture-MS Homo sapiens
15 HINT2 84681
Proximity Label-MS Homo sapiens
16 MRPS24 64951
Affinity Capture-MS Homo sapiens
17 GCAT  
Affinity Capture-MS Homo sapiens
18 GPR55  
Affinity Capture-MS Homo sapiens
19 MRRF  
Proximity Label-MS Homo sapiens
20 KRAS 3845
Negative Genetic Homo sapiens
21 EXD2  
Proximity Label-MS Homo sapiens
22 TULP3 7289
Affinity Capture-MS Homo sapiens
23 DNAJC7 7266
Proximity Label-MS Homo sapiens
24 TARSL2 123283
Two-hybrid Homo sapiens
25 MRPS12  
Proximity Label-MS Homo sapiens
26 FKBPL  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
27 LAMTOR1 55004
Proximity Label-MS Homo sapiens
28 MRPS30 10884
Affinity Capture-MS Homo sapiens
29 SLC25A10 1468
Affinity Capture-MS Homo sapiens
30 C6orf203  
Proximity Label-MS Homo sapiens
31 ACSM5 54988
Affinity Capture-MS Homo sapiens
32 PRPH 5630
Proximity Label-MS Homo sapiens
33 PARK2  
Affinity Capture-MS Homo sapiens
34 P2RY8  
Affinity Capture-MS Homo sapiens
35 AMACR 23600
Affinity Capture-MS Homo sapiens
36 TUFM 7284
Proximity Label-MS Homo sapiens
37 DHRS2 10202
Affinity Capture-MS Homo sapiens
38 NTRK1 4914
Affinity Capture-MS Homo sapiens
39 GPR182  
Affinity Capture-MS Homo sapiens
40 F12  
Affinity Capture-MS Homo sapiens
41 CHORDC1 26973
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
42 Mad2l2  
Affinity Capture-MS Mus musculus
43 MTRF1L  
Proximity Label-MS Homo sapiens
44 RASL10B  
Affinity Capture-MS Homo sapiens
45 COX4I1 1327
Proximity Label-MS Homo sapiens
46 KDF1  
Affinity Capture-MS Homo sapiens
47 CISD3 284106
Affinity Capture-MS Homo sapiens
48 AK4 205
Affinity Capture-MS Homo sapiens
49 AIFM1 9131
Proximity Label-MS Homo sapiens
50 NAA38  
Affinity Capture-MS Homo sapiens
51 MTIF2 4528
Proximity Label-MS Homo sapiens
52 AMBRA1  
Affinity Capture-MS Homo sapiens
53 C2orf47  
Affinity Capture-MS Homo sapiens
54 ASB6 140459
Two-hybrid Homo sapiens
55 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 RMND1 55005
Proximity Label-MS Homo sapiens
57 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
58 FAHD1 81889
Affinity Capture-MS Homo sapiens
59 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
60 ADAM7  
Affinity Capture-MS Homo sapiens
61 C12orf65  
Proximity Label-MS Homo sapiens
62 RPA3 6119
Proximity Label-MS Homo sapiens
63 GPR45  
Affinity Capture-MS Homo sapiens
64 CBR4  
Affinity Capture-MS Homo sapiens
65 PLIN3 10226
Two-hybrid Homo sapiens
66 DDRGK1 65992
Affinity Capture-MS Homo sapiens
67 OXCT2  
Affinity Capture-MS Homo sapiens
68 HAX1  
Proximity Label-MS Homo sapiens
69 MRPS17 51373
Affinity Capture-MS Homo sapiens
70 AKAP1 8165
Proximity Label-MS Homo sapiens
71 MCUR1 63933
Proximity Label-MS Homo sapiens
72 AHSA1 10598
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
73 CLPP 8192
Proximity Label-MS Homo sapiens
74 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
75 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
76 LDHAL6B 92483
Affinity Capture-MS Homo sapiens
77 AUH 549
Proximity Label-MS Homo sapiens
78 FBXL6  
Affinity Capture-MS Homo sapiens
79 MRPS2 51116
Affinity Capture-MS Homo sapiens
80 C20orf96  
Affinity Capture-MS Homo sapiens
81 HOMEZ  
Two-hybrid Homo sapiens
82 ICT1 3396
Affinity Capture-MS Homo sapiens
83 DNAJA2 10294
Proximity Label-MS Homo sapiens
84 TNFSF14  
Affinity Capture-MS Homo sapiens
85 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
86 TNFRSF10D 8793
Two-hybrid Homo sapiens
87 PDHA1 5160
Proximity Label-MS Homo sapiens
88 LCK 3932
Proximity Label-MS Homo sapiens
89 NDUFS7 374291
Affinity Capture-MS Homo sapiens
90 C21orf33  
Proximity Label-MS Homo sapiens
91 NIPSNAP3B 55335
Affinity Capture-MS Homo sapiens
92 SSBP1 6742
Proximity Label-MS Homo sapiens
93 ANAPC2 29882
Proximity Label-MS Homo sapiens
94 AARS2  
Proximity Label-MS Homo sapiens
95 TEFM  
Proximity Label-MS Homo sapiens
96 LRRC61 65999
Proximity Label-MS Homo sapiens
97 MYL10 93408
Affinity Capture-MS Homo sapiens
98 QRSL1  
Affinity Capture-MS Homo sapiens
99 C9orf72  
Affinity Capture-MS Homo sapiens
100 METTL17  
Proximity Label-MS Homo sapiens
101 PTPN18 26469
Affinity Capture-MS Homo sapiens
102 TRIM43  
Affinity Capture-MS Homo sapiens
103 HLA-C 3107
Affinity Capture-MS Homo sapiens
104 SHC2 25759
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TARS2 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Mitochondrial tRNA aminoacylation IEA Reactome
Translation IEA Reactome
tRNA Aminoacylation IEA Reactome





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