Gene description for SHC2
Gene name SHC (Src homology 2 domain containing) transforming protein 2
Gene symbol SHC2
Other names/aliases SCK
SHCB
SLI
Species Homo sapiens
 Database cross references - SHC2
ExoCarta ExoCarta_25759
Entrez Gene 25759
HGNC 29869
MIM 605217
UniProt P98077  
 SHC2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for SHC2
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
    receptor tyrosine kinase binding GO:0030971 IBA
Biological Process
    Ras protein signal transduction GO:0007265 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    activation of MAPK activity GO:0000187 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    insulin receptor signaling pathway GO:0008286 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cellular_component GO:0005575 ND
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified SHC2 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for SHC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RICS  
Affinity Capture-Western Homo sapiens
2 KDR  
Two-hybrid Homo sapiens
View the network image/svg+xml



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