Gene ontology annotations for DARS2
Experiment description of studies that identified DARS2 in sEVs
1
Experiment ID
489
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 6
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
2
Experiment ID
490
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 7
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
3
Experiment ID
491
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 8
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
4
Experiment ID
492
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 9
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
5
Experiment ID
412
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Breast cancer cells
Sample name
MCF7
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
6
Experiment ID
414
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Breast cancer cells
Sample name
MDA-MB-231
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
7
Experiment ID
407
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Embryonic kidney cells
Sample name
HEK293T
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
8
Experiment ID
405
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Foreskin fibroblasts
Sample name
BJ
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
9
Experiment ID
417
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Lymphoma cells
Sample name
Raji
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
10
Experiment ID
411
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Mammary cancer-associated fibroblasts
Sample name
mCAF
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
11
Experiment ID
488
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Homo sapiens
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Mesenchymal stem cells
Sample name
UCMSC
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
12
Experiment ID
418
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Monocytic leukemia cells
Sample name
THP-1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
13
Experiment ID
413
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Normal mammary epithelial cells
Sample name
MCF10A
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
14
Experiment ID
406
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Pancreatic cancer cells
Sample name
BxPC3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
15
Experiment ID
415
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Pancreatic cancer cells
Sample name
PANC-1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
16
Experiment ID
408
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Pancreatic duct epithalial cells
Sample name
HPDE
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
17
Experiment ID
409
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Pancreatic duct epithalial cells
Sample name
HPNE
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
18
Experiment ID
416
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Pluripotent stem cells
Sample name
PSC
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
19
Experiment ID
410
MISEV standards
✔
Biophysical techniques
✔
Enriched markers
✔
Negative markers
✔
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
34108659
Organism
Homo sapiens
Experiment description
Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors
"Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name
Nat Cell Biol
Publication year
2021
Sample
T lymphocytes
Sample name
Jurkat
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein mRNA
Methods used in the study
RT-qPCR Western blotting Mass spectrometry Flow cytometry
Protein-protein interactions for DARS2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
UQCRFS1
7386
Affinity Capture-MS
Homo sapiens
2
POR
5447
Co-fractionation
Homo sapiens
3
LAMP3
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
4
ARHGEF26
26084
Affinity Capture-MS
Homo sapiens
5
RPA2
6118
Proximity Label-MS
Homo sapiens
Co-fractionation
Homo sapiens
6
CMPK1
51727
Co-fractionation
Homo sapiens
7
MTG2
Proximity Label-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
8
KARS
3735
Co-fractionation
Homo sapiens
Two-hybrid
Homo sapiens
9
BPNT1
10380
Affinity Capture-MS
Homo sapiens
10
EPHA8
Two-hybrid
Homo sapiens
11
CAPZB
832
Affinity Capture-MS
Homo sapiens
12
PARK2
Affinity Capture-MS
Homo sapiens
13
TRMU
Affinity Capture-MS
Homo sapiens
14
YARS2
Affinity Capture-MS
Homo sapiens
15
MRPS24
64951
Affinity Capture-MS
Homo sapiens
16
MRPL12
6182
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
17
GCAT
Affinity Capture-MS
Homo sapiens
18
FTSJ2
29960
Affinity Capture-MS
Homo sapiens
19
MALSU1
Affinity Capture-MS
Homo sapiens
20
KRAS
3845
Synthetic Lethality
Homo sapiens
Negative Genetic
Homo sapiens
21
EXD2
Proximity Label-MS
Homo sapiens
22
KLHL20
Affinity Capture-MS
Homo sapiens
23
MYCN
Affinity Capture-MS
Homo sapiens
24
FEM1A
Affinity Capture-MS
Homo sapiens
25
KIF14
9928
Affinity Capture-MS
Homo sapiens
26
MRPS30
10884
Affinity Capture-MS
Homo sapiens
27
PLAUR
5329
Affinity Capture-MS
Homo sapiens
28
SLC25A10
1468
Affinity Capture-MS
Homo sapiens
29
ACSM5
54988
Affinity Capture-MS
Homo sapiens
30
TSPAN33
340348
Two-hybrid
Homo sapiens
31
FOXI2
Affinity Capture-MS
Homo sapiens
32
GLYATL1
Affinity Capture-MS
Homo sapiens
33
AMACR
23600
Affinity Capture-MS
Homo sapiens
34
FOXL2
Affinity Capture-MS
Homo sapiens
35
BBS1
582
Affinity Capture-MS
Homo sapiens
36
NTRK1
4914
Affinity Capture-MS
Homo sapiens
37
COL8A2
1296
Two-hybrid
Homo sapiens
38
LCN1
3933
Affinity Capture-MS
Homo sapiens
39
NARS2
Co-fractionation
Homo sapiens
40
MTRF1L
Proximity Label-MS
Homo sapiens
41
RASL10B
Affinity Capture-MS
Homo sapiens
42
AIMP2
7965
Two-hybrid
Homo sapiens
43
GAPDHS
26330
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
44
CDIPT
10423
Two-hybrid
Homo sapiens
45
FOXH1
Affinity Capture-MS
Homo sapiens
46
MRPL21
219927
Affinity Capture-MS
Homo sapiens
47
AK4
205
Affinity Capture-MS
Homo sapiens
48
AIFM1
9131
Proximity Label-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
49
MTIF2
4528
Proximity Label-MS
Homo sapiens
50
DNAJC2
27000
Affinity Capture-MS
Homo sapiens
51
THSD7B
Two-hybrid
Homo sapiens
52
METTL20
Affinity Capture-MS
Homo sapiens
53
CS
1431
Proximity Label-MS
Homo sapiens
54
AOC3
8639
Two-hybrid
Homo sapiens
55
CUL3
8452
Affinity Capture-MS
Homo sapiens
56
EGFR
1956
Negative Genetic
Homo sapiens
57
FAHD1
81889
Affinity Capture-MS
Homo sapiens
58
FNTA
2339
Co-fractionation
Homo sapiens
59
FOXL1
Affinity Capture-MS
Homo sapiens
60
OCIAD1
54940
Affinity Capture-MS
Homo sapiens
61
RPA3
6119
Proximity Label-MS
Homo sapiens
62
RBMS1
5937
Co-fractionation
Homo sapiens
63
CBR4
Affinity Capture-MS
Homo sapiens
64
LDHAL6B
92483
Affinity Capture-MS
Homo sapiens
65
PLP2
5355
Two-hybrid
Homo sapiens
66
OXCT2
Affinity Capture-MS
Homo sapiens
67
HSPD1
3329
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
68
FSCN1
6624
Affinity Capture-MS
Homo sapiens
69
CCL4L1
Affinity Capture-MS
Homo sapiens
70
MCUR1
63933
Proximity Label-MS
Homo sapiens
71
NIPSNAP3A
Affinity Capture-MS
Homo sapiens
72
TMEM239
Two-hybrid
Homo sapiens
73
CLPP
8192
Proximity Label-MS
Homo sapiens
74
UNC50
Two-hybrid
Homo sapiens
75
PLEKHA4
57664
Affinity Capture-MS
Homo sapiens
76
TERF2
Affinity Capture-MS
Homo sapiens
77
AUH
549
Proximity Label-MS
Homo sapiens
78
MRPS2
51116
Affinity Capture-MS
Homo sapiens
79
C20orf96
Affinity Capture-MS
Homo sapiens
80
DPYSL5
Two-hybrid
Homo sapiens
81
FOXB1
Affinity Capture-MS
Homo sapiens
82
MEN1
4221
Affinity Capture-MS
Homo sapiens
83
ACAA2
10449
Affinity Capture-MS
Homo sapiens
84
PDHA1
5160
Proximity Label-MS
Homo sapiens
85
DNAJA3
9093
Affinity Capture-MS
Homo sapiens
Proximity Label-MS
Homo sapiens
86
SQSTM1
8878
Proximity Label-MS
Homo sapiens
87
NDUFS7
374291
Affinity Capture-MS
Homo sapiens
88
COX8A
Proximity Label-MS
Homo sapiens
89
C21orf33
Proximity Label-MS
Homo sapiens
90
SSBP1
6742
Proximity Label-MS
Homo sapiens
91
POU2F1
5451
Co-fractionation
Homo sapiens
92
UFL1
23376
Affinity Capture-MS
Homo sapiens
93
AARS2
Proximity Label-MS
Homo sapiens
94
ABHD10
55347
Affinity Capture-MS
Homo sapiens
95
LOC554223
Affinity Capture-MS
Homo sapiens
96
MYL10
93408
Affinity Capture-MS
Homo sapiens
97
C1QBP
708
Proximity Label-MS
Homo sapiens
98
ZUFSP
221302
Affinity Capture-MS
Homo sapiens
99
QRSL1
Affinity Capture-MS
Homo sapiens
100
YBEY
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
101
DCP2
Affinity Capture-MS
Homo sapiens
102
TRIM43
Affinity Capture-MS
Homo sapiens
103
SHC2
25759
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which DARS2 is involved