Gene description for AOC3
Gene name amine oxidase, copper containing 3
Gene symbol AOC3
Other names/aliases HPAO
SSAO
VAP-1
VAP1
Species Homo sapiens
 Database cross references - AOC3
ExoCarta ExoCarta_8639
Vesiclepedia VP_8639
Entrez Gene 8639
HGNC 550
MIM 603735
UniProt Q16853  
 AOC3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for AOC3
Molecular Function
    copper ion binding GO:0005507 IBA
    copper ion binding GO:0005507 IDA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    primary methylamine oxidase activity GO:0008131 IDA
    primary methylamine oxidase activity GO:0008131 IDA
    identical protein binding GO:0042802 IPI
    protein heterodimerization activity GO:0046982 IPI
    quinone binding GO:0048038 IDA
    aliphatic amine oxidase activity GO:0052595 IEA
Biological Process
    inflammatory response GO:0006954 TAS
    cell adhesion GO:0007155 IDA
    amine metabolic process GO:0009308 IBA
    amine metabolic process GO:0009308 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    microvillus GO:0005902 IDA
    cell surface GO:0009986 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified AOC3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for AOC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MANEA 79694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LMAN2 10960
Affinity Capture-MS Homo sapiens
3 DDRGK1 65992
Affinity Capture-MS Homo sapiens
4 SGTA 6449
Two-hybrid Homo sapiens
5 ATP4A 495
Affinity Capture-MS Homo sapiens
6 PRRG4  
Two-hybrid Homo sapiens
7 CLDN9  
Two-hybrid Homo sapiens
8 AOC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ARL13B 200894
Two-hybrid Homo sapiens
10 EXTL2 2135
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FNDC9  
Two-hybrid Homo sapiens
12 STX1A 6804
Two-hybrid Homo sapiens
13 ARL6IP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FUT4  
Affinity Capture-MS Homo sapiens
15 TAF6L 10629
Affinity Capture-MS Homo sapiens
16 HSD17B13  
Two-hybrid Homo sapiens
17 CPLX4  
Two-hybrid Homo sapiens
18 SLC9A1 6548
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ERF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 DARS2 55157
Two-hybrid Homo sapiens
21 CREB3L1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AOC3 is involved
PathwayEvidenceSource
Biological oxidations TAS Reactome
Metabolism TAS Reactome
Phase I - Functionalization of compounds TAS Reactome





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