Gene description for FNTA
Gene name farnesyltransferase, CAAX box, alpha
Gene symbol FNTA
Other names/aliases FPTA
PGGT1A
PTAR2
Species Homo sapiens
 Database cross references - FNTA
ExoCarta ExoCarta_2339
Entrez Gene 2339
HGNC 3782
MIM 134635
UniProt P49354  
 FNTA identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FNTA
Molecular Function
    acetylcholine receptor regulator activity GO:0030548 IEA
    protein binding GO:0005515 IPI
    protein geranylgeranyltransferase activity GO:0004661 IDA
    protein farnesyltransferase activity GO:0004660 IDA
    microtubule binding GO:0008017 IDA
    receptor tyrosine kinase binding GO:0030971 IEA
    Rab geranylgeranyltransferase activity GO:0004663 IEA
    CAAX-protein geranylgeranyltransferase activity GO:0004662 IEA
    alpha-tubulin binding GO:0043014 IDA
Biological Process
    protein farnesylation GO:0018343 IDA
    regulation of receptor activity GO:0010469 IEA
    protein geranylgeranylation GO:0018344 IDA
    cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS
    regulation of rhodopsin mediated signaling pathway GO:0022400 TAS
    phototransduction, visible light GO:0007603 TAS
    programmed cell death GO:0012501 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 TAS
    positive regulation of deacetylase activity GO:0090045 IDA
    apoptotic process GO:0006915 TAS
    neurotransmitter receptor metabolic process GO:0045213 IEA
    rhodopsin mediated signaling pathway GO:0016056 TAS
    positive regulation of tubulin deacetylation GO:0090044 IDA
Subcellular Localization
    microtubule associated complex GO:0005875 IDA
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 TAS
    protein farnesyltransferase complex GO:0005965 IDA
    CAAX-protein geranylgeranyltransferase complex GO:0005953 IDA
 Experiment description of studies that identified FNTA in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FNTA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTP4A2 8073
Affinity Capture-MS Homo sapiens
2 FNTB  
Affinity Capture-MS Homo sapiens
3 ACVR1 90
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
4 TGFBR1  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
5 TGFB1 7040
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
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