Gene description for TFPI2
Gene name tissue factor pathway inhibitor 2
Gene symbol TFPI2
Other names/aliases PP5
REF1
TFPI-2
Species Homo sapiens
 Database cross references - TFPI2
ExoCarta ExoCarta_7980
Vesiclepedia VP_7980
Entrez Gene 7980
HGNC 11761
MIM 600033
UniProt P48307  
 TFPI2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for TFPI2
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    extracellular matrix structural constituent GO:0005201 TAS
Biological Process
    blood coagulation GO:0007596 IEA
    cellular response to fluid shear stress GO:0071498 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular matrix GO:0031012 TAS
 Experiment description of studies that identified TFPI2 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for TFPI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CENPB 1059
Affinity Capture-MS Homo sapiens
2 PROS1 5627
Affinity Capture-MS Homo sapiens
3 TTC30A 92104
Affinity Capture-MS Homo sapiens
4 AP3B1 8546
Affinity Capture-MS Homo sapiens
5 SKIL  
Two-hybrid Homo sapiens
6 MYCBP2 23077
Affinity Capture-MS Homo sapiens
7 SORL1 6653
Affinity Capture-MS Homo sapiens
8 AHCYL1 10768
Affinity Capture-MS Homo sapiens
9 NOS1AP  
Affinity Capture-MS Homo sapiens
10 CLUAP1 23059
Affinity Capture-MS Homo sapiens
11 ATE1 11101
Affinity Capture-MS Homo sapiens
12 DSTYK 25778
Affinity Capture-MS Homo sapiens
13 IFT52 51098
Affinity Capture-MS Homo sapiens
14 IFT57 55081
Affinity Capture-MS Homo sapiens
15 TRIM26 7726
Affinity Capture-MS Homo sapiens
16 FNTA 2339
Affinity Capture-MS Homo sapiens
17 NAP1L1 4673
Affinity Capture-MS Homo sapiens
18 WDR89  
Affinity Capture-MS Homo sapiens
19 KBTBD7  
Affinity Capture-MS Homo sapiens
20 AHCYL2 23382
Affinity Capture-MS Homo sapiens
21 IFT46 56912
Affinity Capture-MS Homo sapiens
22 IFT74 80173
Affinity Capture-MS Homo sapiens
23 UBE2O 63893
Affinity Capture-MS Homo sapiens
24 C18orf25 147339
Affinity Capture-MS Homo sapiens
25 IFT88 8100
Affinity Capture-MS Homo sapiens
26 IFT172 26160
Affinity Capture-MS Homo sapiens
27 FNTB 2342
Affinity Capture-MS Homo sapiens
28 SMURF2 64750
Two-hybrid Homo sapiens
29 MYC  
Affinity Capture-MS Homo sapiens
30 IFT81 28981
Affinity Capture-MS Homo sapiens
31 DCAF5  
Affinity Capture-MS Homo sapiens
32 IFT22 64792
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TFPI2 is involved
No pathways found





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