Gene description for IFT52
Gene name intraflagellar transport 52
Gene symbol IFT52
Other names/aliases C20orf9
CGI-53
NGD2
NGD5
Species Homo sapiens
 Database cross references - IFT52
ExoCarta ExoCarta_51098
Entrez Gene 51098
HGNC 15901
UniProt Q9Y366  
 IFT52 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IFT52
Molecular Function
    protein C-terminus binding GO:0008022 ISS
Biological Process
    intraciliary transport GO:0042073 IBA
    dorsal/ventral pattern formation GO:0009953 IEA
    cilium morphogenesis GO:0060271 IBA
    smoothened signaling pathway GO:0007224 IEA
    heart looping GO:0001947 IEA
    regulation of protein processing GO:0070613 IEA
    embryonic digit morphogenesis GO:0042733 IEA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    organelle organization GO:0006996 TAS
    neural tube formation GO:0001841 IEA
Subcellular Localization
    ciliary tip GO:0097542 TAS
    centriole GO:0005814 IBA
    intraciliary transport particle B GO:0030992 ISS
    photoreceptor connecting cilium GO:0032391 IEA
    primary cilium GO:0072372 TAS
    motile cilium GO:0031514 ISS
    ciliary base GO:0097546 IEA
    dendrite terminus GO:0044292 IEA
 Experiment description of studies that identified IFT52 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IFT52
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IFT52 is involved
PathwayEvidenceSource
Hedgehog 'off' state TAS Reactome
Intraflagellar transport TAS Reactome





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