Gene description for SMURF2
Gene name SMAD specific E3 ubiquitin protein ligase 2
Gene symbol SMURF2
Other names/aliases -
Species Homo sapiens
 Database cross references - SMURF2
ExoCarta ExoCarta_64750
Vesiclepedia VP_64750
Entrez Gene 64750
HGNC 16809
MIM 605532
UniProt Q9HAU4  
 SMURF2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SMURF2
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    SMAD binding GO:0046332 IBA
    SMAD binding GO:0046332 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin protein ligase activity GO:0061630 TAS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    protein ubiquitination GO:0016567 IEA
    regulation of transforming growth factor beta receptor signaling pathway GO:0017015 NAS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS
    negative regulation of BMP signaling pathway GO:0030514 IBA
    negative regulation of BMP signaling pathway GO:0030514 TAS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    negative regulation of DNA-templated transcription GO:0045892 NAS
    Wnt signaling pathway, planar cell polarity pathway GO:0060071 TAS
    positive regulation of canonical Wnt signaling pathway GO:0090263 TAS
    positive regulation of trophoblast cell migration GO:1901165 IDA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    nuclear speck GO:0016607 IDA
    membrane raft GO:0045121 IEA
 Experiment description of studies that identified SMURF2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMURF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
2 LINGO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TRAF4 9618
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 PAWR 5074
Affinity Capture-MS Homo sapiens
5 MYLK2 85366
Affinity Capture-MS Homo sapiens
6 Irf8  
Affinity Capture-Luminescence Mus musculus
7 Ash2l  
Affinity Capture-Luminescence Mus musculus
8 Smad2  
Affinity Capture-Luminescence Mus musculus
9 Gar1  
Affinity Capture-Luminescence Mus musculus
10 UBC 7316
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
11 SEMG2 6407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 Fkbp4 14228
Affinity Capture-Luminescence Mus musculus
13 ILF2 3608
Affinity Capture-MS Homo sapiens
14 TGFBR1 7046
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 QPRT 23475
Affinity Capture-Western Homo sapiens
16 SNRNP70 6625
Two-hybrid Homo sapiens
17 TRIM28 10155
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
18 ID1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
19 RBM14 10432
Affinity Capture-MS Homo sapiens
20 RTN4IP1  
Two-hybrid Homo sapiens
21 MRPS23 51649
Affinity Capture-MS Homo sapiens
22 SIRT1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
23 RHOA 387
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
24 DGCR2 9993
Two-hybrid Homo sapiens
25 ARHGAP5 394
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 Rab22a 19334
Affinity Capture-Luminescence Mus musculus
27 MRPS7 51081
Affinity Capture-MS Homo sapiens
28 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SMAD5 4090
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MAVS 57506
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 BTRC 8945
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
32 TNFRSF1B  
Affinity Capture-Western Homo sapiens
33 NEDD4 4734
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 Arhgef1 16801
Affinity Capture-Luminescence Mus musculus
35 GSK3B 2932
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 RNF11 26994
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
37 Nras 18176
Affinity Capture-Luminescence Mus musculus
38 NEDD9 4739
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 SF3A2 8175
Two-hybrid Homo sapiens
40 RPS19 6223
Affinity Capture-MS Homo sapiens
41 Anapc5 59008
Affinity Capture-Luminescence Mus musculus
42 Srsf4  
Affinity Capture-Luminescence Mus musculus
43 ADAR 103
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
44 PARK2  
Affinity Capture-MS Homo sapiens
45 Nkiras1  
Affinity Capture-Luminescence Mus musculus
46 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
47 DAZAP2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
48 LAPTM5 7805
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 UBE2I 7329
Affinity Capture-Western Homo sapiens
50 SKIL  
Affinity Capture-Western Homo sapiens
51 TMEM139  
Two-hybrid Homo sapiens
52 FUBP1 8880
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
53 TNPO3 23534
Two-hybrid Homo sapiens
54 KRIT1 889
Affinity Capture-MS Homo sapiens
55 SMAD3 4088
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
56 SMAD2 4087
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
57 UBE2D3 7323
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
58 KCTD12 115207
Affinity Capture-MS Homo sapiens
59 GLIS3  
Affinity Capture-Western Homo sapiens
60 ID3  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
61 STAMBP 10617
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 Rac1 19353
Affinity Capture-Luminescence Mus musculus
63 UBE2D1 7321
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
64 ENAH 55740
Affinity Capture-MS Homo sapiens
65 SETD7 80854
Affinity Capture-Western Homo sapiens
66 AIMP2 7965
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
67 ACBD3 64746
Two-hybrid Homo sapiens
68 Smad7  
Affinity Capture-Luminescence Mus musculus
69 ESF1 51575
Affinity Capture-MS Homo sapiens
70 CCM2 83605
Affinity Capture-Western Homo sapiens
71 CANX 821
Two-hybrid Homo sapiens
72 RPS2 6187
Affinity Capture-MS Homo sapiens
73 XPO1 7514
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
74 USP15 9958
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
75 YBX1 4904
Affinity Capture-MS Homo sapiens
76 UBE2L3 7332
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
77 RLIM 51132
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
78 Smad3  
Affinity Capture-Luminescence Mus musculus
79 ITGB1BP1 9270
Reconstituted Complex Homo sapiens
80 TTC3 7267
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
82 YY1 7528
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
83 PIAS3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
84 RUNX3  
Affinity Capture-Western Homo sapiens
85 SMAD1 4086
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
86 Epha1  
Affinity Capture-Luminescence Mus musculus
87 Ube2g1  
Affinity Capture-Luminescence Mus musculus
88 FLNB 2317
Two-hybrid Homo sapiens
89 Smad6  
Affinity Capture-Luminescence Mus musculus
90 TFPI2 7980
Two-hybrid Homo sapiens
91 RUNX2  
Biochemical Activity Homo sapiens
92 ACOX3 8310
Two-hybrid Homo sapiens
93 Rhod  
Affinity Capture-Luminescence Mus musculus
94 CCDC144B  
Affinity Capture-MS Homo sapiens
95 DNAJC10 54431
Affinity Capture-MS Homo sapiens
96 SMARCA2 6595
Affinity Capture-MS Homo sapiens
97 SMAD6  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
98 UBE2D2 7322
Reconstituted Complex Homo sapiens
99 MARS2 92935
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 Nek6  
Affinity Capture-Luminescence Mus musculus
101 Rab14 68365
Affinity Capture-Luminescence Mus musculus
102 SATB1 6304
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
103 H2AFX 3014
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 Ing2  
Affinity Capture-Luminescence Mus musculus
105 BRAF  
Affinity Capture-Western Homo sapiens
106 Hdgfrp3  
Affinity Capture-Luminescence Mus musculus
107 FBXL15  
Affinity Capture-Western Homo sapiens
108 Stat1 20846
Affinity Capture-Luminescence Mus musculus
109 FAM175B 23172
Two-hybrid Homo sapiens
110 TRAF2 7186
Affinity Capture-Western Homo sapiens
111 DAB2 1601
Two-hybrid Homo sapiens
112 SLC25A6 293
Affinity Capture-MS Homo sapiens
113 PDE4B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
114 TGFBR2 7048
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
116 Rab13 68328
Affinity Capture-Luminescence Mus musculus
117 MRPS31  
Affinity Capture-MS Homo sapiens
118 Rab17  
Affinity Capture-Luminescence Mus musculus
119 UBA52 7311
Affinity Capture-MS Homo sapiens
120 SMURF1 57154
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 EFNB1 1947
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
122 SMAD4  
Affinity Capture-Western Homo sapiens
123 HSPB1 3315
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
124 Irf3  
Affinity Capture-Luminescence Mus musculus
125 Rnf14  
Affinity Capture-Luminescence Mus musculus
126 RNF20 56254
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
127 Smap1  
Affinity Capture-Luminescence Mus musculus
128 AXIN1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
129 LATS1  
Protein-peptide Homo sapiens
130 Rras2 66922
Affinity Capture-Luminescence Mus musculus
131 KLF5  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
132 AOC2  
Affinity Capture-MS Homo sapiens
133 Rasd2  
Affinity Capture-Luminescence Mus musculus
134 ACTA2 59
Affinity Capture-MS Homo sapiens
135 RNF111 54778
Two-hybrid Homo sapiens
136 SPG20 23111
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 Rnf2  
Affinity Capture-Luminescence Mus musculus
138 TXNIP 10628
Two-hybrid Homo sapiens
139 AIMP1 9255
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
140 SMURF2 64750
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
141 MRPS22 56945
Affinity Capture-MS Homo sapiens
142 CUEDC1 404093
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
143 PTCH1  
Affinity Capture-Western Homo sapiens
144 PRMT1 3276
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
145 SLC25A5 292
Affinity Capture-MS Homo sapiens
146 Smad1  
Affinity Capture-Luminescence Mus musculus
147 Gng2 14702
Affinity Capture-Luminescence Mus musculus
148 NEDD8 4738
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
149 Ppid 67738
Affinity Capture-Luminescence Mus musculus
150 BCR 613
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SMURF2 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
Asymmetric localization of PCP proteins TAS Reactome
Beta-catenin independent WNT signaling TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Degradation of AXIN TAS Reactome
Deubiquitination TAS Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity IEA Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity TAS Reactome
Downregulation of TGF-beta receptor signaling TAS Reactome
Downregulation of TGF-beta receptor signaling IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
Hedgehog 'on' state TAS Reactome
Hedgehog 'on' state IEA Reactome
Immune System TAS Reactome
Metabolism of proteins TAS Reactome
PCP/CE pathway TAS Reactome
Post-translational protein modification TAS Reactome
Regulation of RUNX3 expression and activity TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by BMP TAS Reactome
Signaling by Hedgehog TAS Reactome
Signaling by Hedgehog IEA Reactome
Signaling by TGF-beta Receptor Complex TAS Reactome
Signaling by TGF-beta Receptor Complex IEA Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFB family members IEA Reactome
Signaling by WNT TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
TGF-beta receptor signaling activates SMADs TAS Reactome
TGF-beta receptor signaling activates SMADs IEA Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IEA Reactome
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer TAS Reactome
Transcriptional regulation by RUNX3 TAS Reactome
Ub-specific processing proteases TAS Reactome





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