Gene description for RNF11
Gene name ring finger protein 11
Gene symbol RNF11
Other names/aliases CGI-123
SID1669
Species Homo sapiens
 Database cross references - RNF11
ExoCarta ExoCarta_26994
Vesiclepedia VP_26994
Entrez Gene 26994
HGNC 10056
MIM 612598
UniProt Q9Y3C5  
 RNF11 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for RNF11
Molecular Function
    DNA binding GO:0003677 TAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 TAS
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    protein autoubiquitination GO:0051865 IDA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    ubiquitin ligase complex GO:0000151 IDA
    nucleus GO:0005634 IEA
    early endosome GO:0005769 IEA
    recycling endosome GO:0055037 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified RNF11 in exosomes
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
5
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for RNF11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Affinity Capture-MS Homo sapiens
2 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 TNIP1 10318
Two-hybrid Homo sapiens
4 AP2B1 163
Affinity Capture-MS Homo sapiens
5 QARS 5859
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 PSMD6 9861
Affinity Capture-MS Homo sapiens
7 AP2S1 1175
Affinity Capture-MS Homo sapiens
8 WWP1 11059
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
9 SMURF1 57154
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
10 PSMD11 5717
Affinity Capture-MS Homo sapiens
11 USP5 8078
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 EPS15 2060
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 UBC 7316
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 SLC25A48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PSMD10 5716
Affinity Capture-MS Homo sapiens
16 PSMD4 5710
Affinity Capture-MS Homo sapiens
17 RIPK1 8737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 STX4 6810
Affinity Capture-MS Homo sapiens
19 RNF216  
Two-hybrid Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 ZNF350  
Two-hybrid Homo sapiens
22 SNRNP70 6625
Two-hybrid Homo sapiens
23 SLC20A1 6574
Affinity Capture-MS Homo sapiens
24 UBE2E2  
Two-hybrid Homo sapiens
25 UBE2L3 7332
Affinity Capture-MS Homo sapiens
26 UBE2O 63893
Affinity Capture-MS Homo sapiens
27 AP2A1 160
Affinity Capture-MS Homo sapiens
28 HGS 9146
Affinity Capture-Western Homo sapiens
29 SRC 6714
Affinity Capture-MS Homo sapiens
30 PSMD12 5718
Affinity Capture-MS Homo sapiens
31 CALCOCO2  
Two-hybrid Homo sapiens
32 GGA1 26088
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
33 IKBKE 9641
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 POLI  
Two-hybrid Homo sapiens
35 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PSMD5 5711
Affinity Capture-MS Homo sapiens
37 USP2  
Affinity Capture-MS Homo sapiens
38 CBLB 868
Two-hybrid Homo sapiens
39 SDCBP 6386
Affinity Capture-MS Homo sapiens
40 USP7 7874
Affinity Capture-MS Homo sapiens
41 UBQLN4 56893
Two-hybrid Homo sapiens
42 ZFYVE9  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 NEDD4 4734
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
44 RNF11 26994
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
45 UBE2V1 7335
Affinity Capture-MS Homo sapiens
46 RABGEF1 27342
Two-hybrid Homo sapiens
47 UBE2E3 10477
Two-hybrid Homo sapiens
48 STAM2 10254
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
49 USP14 9097
Affinity Capture-MS Homo sapiens
50 ZFYVE16  
Two-hybrid Homo sapiens
51 C1orf162  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 UBE2D4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 OPTN 10133
Two-hybrid Homo sapiens
55 PSMD14 10213
Affinity Capture-MS Homo sapiens
56 GTF2H1 2965
Affinity Capture-MS Homo sapiens
57 PSMD2 5708
Affinity Capture-MS Homo sapiens
58 RNF168  
Two-hybrid Homo sapiens
59 PSMD8 5714
Affinity Capture-MS Homo sapiens
60 SAR1B 51128
Affinity Capture-MS Homo sapiens
61 ASCC2 84164
Two-hybrid Homo sapiens
62 YWHAQ 10971
Affinity Capture-Western Homo sapiens
63 UBE2D3 7323
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
64 TNPO2 30000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 STAMBP 10617
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
66 ITCH 83737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
67 ANKRD13A 88455
Two-hybrid Homo sapiens
68 TOM1L2 146691
Two-hybrid Homo sapiens
69 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 UBE2N 7334
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ACVR2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TAX1BP1 8887
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
73 PSMD13 5719
Affinity Capture-MS Homo sapiens
74 UBQLN2 29978
Two-hybrid Homo sapiens
75 VAMP3 9341
Affinity Capture-MS Homo sapiens
76 UBE2E1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
77 PSMD7 5713
Affinity Capture-MS Homo sapiens
78 AP2M1 1173
Affinity Capture-MS Homo sapiens
79 CCDC127  
Two-hybrid Homo sapiens
80 UBE2D2 7322
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
81 SOAT1 6646
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 DCUN1D1 54165
Two-hybrid Homo sapiens
83 STAT1 6772
Affinity Capture-Western Homo sapiens
84 MYO6 4646
Two-hybrid Homo sapiens
85 EPN3 55040
Two-hybrid Homo sapiens
86 EPN1 29924
Two-hybrid Homo sapiens
87 CSNK2B 1460
Affinity Capture-MS Homo sapiens
88 LTN1 26046
Affinity Capture-MS Homo sapiens
89 AKT1 207
Biochemical Activity Homo sapiens
90 NEDD4L 23327
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
91 UBE2U  
Two-hybrid Homo sapiens
92 UBE2D1 7321
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
93 DZIP3  
Affinity Capture-MS Homo sapiens
94 GGA3 23163
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
95 RPS27A 6233
Two-hybrid Homo sapiens
96 PTPRC 5788
Two-hybrid Homo sapiens
97 ASNS 440
Affinity Capture-MS Homo sapiens
98 PDCD6IP 10015
Two-hybrid Homo sapiens
99 FANCL 55120
Two-hybrid Homo sapiens
100 IKBKG 8517
Two-hybrid Homo sapiens
101 UBA52 7311
Two-hybrid Homo sapiens
102 SMAD4  
Affinity Capture-Western Homo sapiens
103 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
104 AUP1 550
Two-hybrid Homo sapiens
105 TBK1 29110
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
106 WWP2 11060
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
107 ERCC6  
Two-hybrid Homo sapiens
108 DDR1 780
Affinity Capture-MS Homo sapiens
109 GGA2 23062
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
110 GTF2H4 2968
Affinity Capture-MS Homo sapiens
111 BMPR2 659
Affinity Capture-MS Homo sapiens
112 SMURF2 64750
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
113 PSMD1 5707
Affinity Capture-MS Homo sapiens
114 UBE2G1 7326
Affinity Capture-MS Homo sapiens
115 UBE2V2 7336
Affinity Capture-MS Homo sapiens
116 PSMD3 5709
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RNF11 is involved
No pathways found





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